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PDF(246 KB)
PDF(246 KB)
可诱导核酸交联剂的研究进展*
- 翁小成 翁立伟 白明慧 周泱泱 周翔**
作者信息
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Studies of Inducible DNA Cross-Linking Agents
- Weng Xiaocheng; Weng Liwei; Bai Minghui; Zhou Yangyang; Zhou Xiang**
Author information
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文章历史
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摘要
如何选择性的破坏癌细胞DNA链结构的药物，一直是研究的热点，可诱导核酸交联剂在增加药物靶标选择性方面有很多的优点，利用氧化、还原或光诱导产生的DNA交联作用，在临床治疗中具有重要意义，本文就可诱导核酸交联剂的最新研究进展做了评述。
Abstract
Selectively destroy the DNA of the tumor cells by induction has been arosed many attention for medicinal application. Inducible DNA cross-linking agents have provided a promising method for these researches. As the improving the selectivity of the targets induced by various methods, such as oxidation, reduction and light-induction to cross-link DNA, they hold great importance on clinic therapy. This paper has reported and summarized the most recent advances on inducible DNA cross-linking agents.
关键词
DNA 交联 / 诱导 {{custom_keyword}} /
Key words
中图分类号：
Q52
Q503
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参考文献
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