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PDF(459 KB)
PDF(459 KB)
生物催化与新药研究和开发
- 陈依军* 吴旭日
作者信息
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Biocatalysis in Drug Discovery and Development
- Chen Yijun* Wu Xuri
Author information
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文章历史
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摘要
生物催化具有条件温和、效率高、选择性强、副产物少等特点，因此生物催化在新药的研究和开发中得到广泛的应用；此外，利用生物技术对生物催化剂进行改造优化，将使其能够更好地应用于新颖的生产工艺。本文对此领域的进展作一简单介绍和概述。
Abstract
Due to the advantages including mild conditions, high catalytic efficiency, high stereoselectivity and regioselectivity and less byproducts, biocatalysis has been widely utilized and applied in drug discovery and development. Moreover, biocatlysts can be structurally changed and optimized through new technologies such as directed evolution, which could be better suited for biocatalytic processes. In this review, recent progress in the field of application of biocatalysis in drug discovery and development is briefly introduced and discussed.
关键词
生物催化 / 生物催化剂 / 代谢产物 / 手性化合物 / 新药研究和开发 {{custom_keyword}} /
Key words
biocatlysis / biocatalyst / metabolites / chiral drugs / drug discovery and development {{custom_keyword}} /
中图分类号：
Q5.3
O643.32
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