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化学进展 2004, Vol. 16 Issue (05): 785- 前一篇   后一篇

• 综述与评论 •

叶酸辅酶参与的一碳单元转移反应*

乔青安;蔡政亭**;冯大诚   

  1. (山东大学理论化学研究所 济南 250100)
  • 收稿日期:2003-06-01 修回日期:2003-09-01 出版日期:2004-10-14 发布日期:2004-10-14
  • 通讯作者: 蔡政亭

Progress in the Folate Coenzyme Participated Reaction of One-Carbon Unit Transfer

Qiao Qingan;Cai Zhengting**;Feng Dacheng   

  1. (Institute of Theoretical Chemistry, Shandong University, Jinan 250100, China)
  • Received:2003-06-01 Revised:2003-09-01 Online:2004-10-14 Published:2004-10-14
  • Contact: Cai Zhengting
本文介绍了四氢叶酸的分子结构和一碳单元转移反应的生物学功能,从实验和理论两个方面讨论了一碳单元转移反应的研究现状及存在的主要问题,并展望了用量子化学及分子力学方法对该类反应进行进一步理论研究的前景.
The molecular structure of tetrahydrofolate coenzyme and the biological functions of one-carbon unit transfer reactions are summed up briefly in this paper. The progress in enzymatic one-carbon unit transfer research, as well as the main questions that remain unresolved in this research field is reviewed both experimentally and theoretically. The further theoretical study of such reactions in the future by means of quantum chemistry and molecule mechanisms is prospected.

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[ 1 ] Stephen J B , Bullard W P , Benkovic P A. J . Am. Chem. Soc. ,1972 , 94 (21) : 7542 —7549
[ 2 ] 沈同(Shen T) , 王镜岩(Wang J Y) (主编) . 生物化学(上册,下册) (Biochemistry) , 第二版(2nd ed. ) . 高等教育出版社(Higher Education Press) , 1991. 359 —378
[ 3 ] Giovannucci E , Stampfer M J , Colditz GA , et al . Ann. Internal .Med. , 1998 , 129 (7) : 517 —524
[ 4 ] Chan S Y, Cyril J E , Frank J W, et al . Cell , 2001 , 106 (1) :117 —126
[ 5 ] Wills L , Clutterbuck P W, Evans P D F. Biochem. J . , 1937 ,31 : 2136 —2147
[ 6 ] Snear W. Drug Discovery : The Evolution of Modern Medicines.New York : Chichester John Wiley &Sons Ltd , 1985. 227 —247
[ 7 ] Avijit H , Santanu K T. Indian Journal of Pharmacology , 2001 , 33(5) : 322 —342
[ 8 ] Blakely R J . The Biochemistry of Folic Acid Biology of Pteridines.New York : Elsevier , 1969
[ 9 ] Reinald H H , Jim van W, Upendra K P. Tetrahedron Lett . ,1989 , 30 (50) : 7105 —7106
[10] Alex R S , Upendra K P. Tetrahedron , 1989 , 45 (3) : 849 —854
[11] 夏炽中(Xia C Z) , 姚庆伟( Yao Q W) . 化学通报(Chemistry) , 1989 , 52 (1) : 1 —9
[12] 陈建新(Chen J X) , 夏炽中(Xia C Z) . 中国药物化学杂志(Chinese J . Med. Chem. ) , 2001 , 11 (4) : 230 —232
[13] 夏炽中(Xia C Z) , 周培文(Zhou P W) , 赵炳筠(Zhao B Y) .科学通报(Chinese Science Bulletin) , 1995 , 40 (16) : 1533 —1535
[14] 陈建新(Chen J X) , 潘继刚(Pan J G) , 夏炽中(Xia C Z) . 化学学报(Acta Chim. Sinica) , 1998 , 56 (8) : 819 —825
[15] 康从民(Kang C M) , 冯大诚(Feng D C) , 蔡政亭(Cai Z T) .化学通报(Chemistry) , 2001 , 64 (4) : 206 —211
[16] Stephen J B. Ann. Rev. Biochem. , 1980 , 49 : 227 —251
[17] Mark S W, Ariane E M, Stephen J B. Biochemistry , 1996 , 35(27) : 8855 —8862
[18] Jae H S , Stephen J B. Biochemistry , 1999 , 38 (31) : 10024 —10031
[19] Mark S W, Karen M M, Ariane E M, et al . Pure Appl . Chem. ,1996 , 68 (11) : 2029 —2036
[20] Samantha E G, Mason M Y, Hui C , et al . Biochem. , 1999 , 38(51) : 16783 —16793
[21] Mark W, Jae H S , Stephen J B. Biochemistry , 2000 , 39 (37) :11303 —11311
[22] Jae H S , Mark W, Stephen J B , et al . J . Am. Chem. Soc. ,2001 , 123 (20) : 4687 —4696
[23] Almassy R J , Janson C A , Kan C C , et al . Proc. Natl . Acad.Sci . USA , 1992 , 89 : 6114 —6118
[24] Rowena G M, James T D. Chem. Rev. , 1990 , 90 (7) : 1275 —1290
[25] Serge A , Gerald M, Manuel F , et al . J . Am. Chem. Soc. ,1998 , 120 (34) : 8825 —8833
[26] Aline T, David J , Celine B , et al . J . Am. Chem. Soc. , 1999 ,121 (41) : 9693 —9702
[27] Micheal C H , Jason M H , Jeffrey R R , et al . J . Phys. Chem.B , 1999 , 103 (23) : 4906 —4915
[28] Weitao Y. Phys. Rev. Lett . , 1991 , 66 (11) : 1438 —1441
[29] Warshel A. Computer Modeling of Chemical Reactions in Enzyme.New York : Wiley , 1991
[30] Aqvist J , Warshel A. Chem. Rev. , 1993 , 93 (7) : 2523 —2544
[31] Fuxreiter M, Warshel A. J . Am. Chem. Soc. , 1998 , 120 (1) :183 —194
[32] Warshel A , Levitt M. J . Mol . Biol . , 1976 , 103 : 227 —249
[33] Peter L C , Jill E G. J . Comput . Chem. , 1998 , 19 (8) : 977 —988
[34] Peter L C , Jill E G. J . Comput . Chem. , 1999 , 20 (10) : 1028 —1038
[35] Peter L C , Jill E G. J . Phys. Chem. B , 2000 , 104 ( 18) :4503 —4510
[36] Peter L C , Jill E G. J . Am. Chem. Soc. , 2001 , 123 (15) :3418 —3428
[37] Stephen J T, Peter L C , Andrey A B , et al . Chem. Phys. Lett . ,2000 , 320 (1/2) : 169 —176
[38] Stephen J T, Peter L C , Alistair P R , et al . J . Comput . Chem. ,2002 , 23 (14) : 1314 —1322
[39] 康从民(Kang C M) , 戚传松(Qi C S) , 冯大诚( Feng D C) ,等. 化学学报(Acta Chim. Sinica) , 2001 , 59 (7) : 1031 —1037
[40] 康从民(Kang C M) , 戚传松(Qi C S) , 冯大诚( Feng D C) ,等. 中国科学(B 辑) (Science in China Ser. B) , 2002 , 32 (2) :156 —164
[41] 康从民(Kang C M) , 冯大诚( Feng D C) , 戚传松(Qi C S) ,等. 有机化学( Chinese J . Organic Chem. ) , 2002 , 22 ( 9) :624 —630
[42] 康从民(Kang C M) , 冯大诚(Feng D C) , 蔡政亭(Cai Z T) .高等学校化学学报(Chem. J . Chinese Universities) , 2001 , 22(2) : 293 —295
[43] Kang C M, Qi C S , Feng D C , et al . J . Mol . Stru. (Theochem)2002 , 579 (3) : 235 —245
[44] Kang C M, Feng D C , Qi C S , et al . Int . J . Quant . Chem. ,2002 , 87 (3) : 152 —157
[45] 戚传松(Qi C S) , 冯大诚(Feng D C) , 吕文彩(Lu W C) , 等.高等学校化学学报(Chem. J . Chinese Universities) , 2002 , 23(6) : 1159

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