无机小分子与细胞中生物大分子的相互作用*

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化学进展 ›› 2004, Vol. 16 ›› Issue (02) : 308.

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黄开勋,刘琼,杨祥良,徐辉碧. 无机小分子与细胞中生物大分子的相互作用^[J]. 化学进展, 2004, 16(02): 308 Huang Kaixun^,Liu Qiong,Yang Xiangliang,Xu Huibi. Interactions between Small Inorganic Molecules and Biological Macromolecules in Cell[J]. Progress in Chemistry*, 2004, 16(02): 308

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无机小分子与细胞中生物大分子的相互作用^*

黄开勋^**;刘琼;杨祥良;徐辉碧

作者信息 +

Interactions between Small Inorganic Molecules and Biological Macromolecules in Cell

Huang Kaixun^**;Liu Qiong;Yang Xiangliang;Xu Huibi

Author information +

文章历史 +

摘要

细胞是生命体的基本组成单元,是一个复杂的、能真实反映生物体系的活体.以细胞为研究对象,开展无机小分子与大分子相互作用的研究,有可能真正理解生命过程中一些问题的化学本质.无机小分子与细胞生物大分子相互作用的研究内容非常丰富,目前应着重研究那些对人类有严重威胁的一些疾病如糖尿病、心血管病、肿瘤、神经退行性病变等有关的细胞无机化学中无机小分子与生物大分子相互作用的问题.这对于了解生物大分子的结构、功能,对于疾病预防和治疗,了解小分子对生命过程的调控机制,对于药物作用新靶点的发现、药物的分子设计、作用机理和药物的研究与开发,均具有十分重要的科学意义和应用价值.论文还就开展无机小分子与细胞中生物大分子的相互作用研究的目标和内容提出了具体的建议.

Abstract

Cell is a component unit of organism which presents the complexity and factuality of life system. As a re-search object, it is possible to understand the chemical nature of some biological occurrences if the interactions between inorganic molecules and biological macromolecules in cell are studied. There are a lot of problems to be studied in this field, but at present the matters of related diseases severely threatening human health, such as diabetes mellitus, cardio-vascular diseases, cancer, neuropathic degenerative diseases, should be taken precedence. It has important scientific sig-nificance and application value if the research project will be implemented, because it is propitious to understand structure-function relationship, prevent and cure some related diseases, comprehend the regulation mechanism of inorganic molecules to biological reactions, discover new target molecules of drug action, design and develop medicines. In this proposal, the research goal and contents are also given concretely.

关键词

无机小分子 / 生物大分子 / 细胞生物无机化学 / 项目建议

Key words

inorganic molecules / biological macromolecules / cellular bioinorganic chemistry / project proposal

中图分类号： Q26 Q71

参考文献

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