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化学进展 2004, Vol. 16 Issue (02): 145-   后一篇

• 综述与评论 •

水分子通道蛋白的结构与功能

隋海心*;任罡   

  1. (Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA)
  • 收稿日期:2004-01-01 修回日期:1900-01-01 出版日期:2004-03-24 发布日期:2004-03-24
  • 通讯作者: 隋海心;任罡
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导出 被引次数 ( 152 | 8 )

Structure and Mechanism of Water Channels

Sui Haixin*;Ren Gang   

  1. (Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA)
  • Received:2004-01-01 Revised:1900-01-01 Online:2004-03-24 Published:2004-03-24
  • Contact: Sui Haixin;Ren Gang
水分子穿越双磷脂生物膜的输运机理是生理学和细胞生物学中一个长期未能解决的重要问题.AQP1水通道蛋白的发现和鉴定使得人们确认出一个新的蛋白质家族--水通道蛋白家族.正是这一蛋白家族的存在,使得水分子可以进行快速的跨膜传输.由晶体学方法解出的哺乳动物AQP1水通道蛋白的原子结构,最终揭示了水通道蛋白只允许水分子快速传输而阻挡其他的小分子和离子(包括质子H+)的筛选输运机理.本文概述了水通道蛋白的发现和其对水分子的筛选传输机理.
关键词： 水通道蛋白, 水传输, 结构与功能, 膜通道
The mechanism of water transport across biological membranes has been a longstanding problem in physiology and cell biology. The discoveiy and characterization of the AQPl water channel protein leads to the identification of the aquaporin family of water channels which is responsible for the water permeability of biological membranes. The atom-ic structure of mammalian AQPl reveals how this family of proteins transports water molecules, but not other small mole-cules and ions (including protons), rapidly across cell membranes. This review summarizes the discovery of water chan-nel proteins and their mechanism of water-specific transport.
Key words: aquaporin, water transport, structure and function, membrane channel

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水分子通道蛋白的结构与功能