• 综述 •
蒋炳炎, 彭涛, 袁帅, 周明勇. 微流控芯片上的颗粒被动聚焦技术[J]. 化学进展, 2021, 33(10): 1780-1796.
Bingyan Jiang, Tao Peng, Shuai Yuan, Mingyong Zhou. Passive Focusing Techniques of Particles in Microfluidic Device[J]. Progress in Chemistry, 2021, 33(10): 1780-1796.
微流控芯片上的颗粒聚焦技术已广泛用于生物、化学、工程和医疗等领域。精确的聚焦过程是计数、检测或分选等应用的关键预处理步骤。颗粒聚焦技术根据是否引入外部能场和鞘流,分为主动聚焦、被动聚焦和鞘流辅助聚焦。被动聚焦利用流体的惯性、黏弹性等特性操控颗粒在流体中的平衡位置,拥有结构简单、高通量、生物兼容、低成本和无标记等多重优点。已有大量文献针对微流控芯片上的颗粒被动聚焦技术,从芯片的结构拓展、微流体特性和微粒特性等方面,开展了实验和数值计算研究。本文对微流控芯片上的颗粒被动聚焦技术最新研究进展进行了综述,首先对流体中颗粒受到的水动力和聚焦相关原则进行阐述,进一步详细综述被动聚焦技术进展,最后对该技术的未来发展作出了展望。
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Channel structure | Channel dimension(μm) | Particle(a in μm) | Length fraction | Flow rate | Dimensionless number | ref |
---|---|---|---|---|---|---|
Straight rectangular | (100,120,140,160)×25 | PS (9.9) | 0.06~0.93%v/v | 0.003~0.096 mL/min | Rp (0.4~1.6) | 74 |
Straight Trapezoid | (100~200)×(50~70) | PS (10,20,45) | 0.1%v/v | 0.05~5 mL/min | Rc (20~800) | 78 |
Straight rectangular | (25~35)×47 | PS (3,6) | 0.08%w/v | 20~110 μL/min | Rc (13~72) | 81 |
Straight triangle | 100×50 μm, 120° | PS (7,10,15,18) | ~(1~2)×105/mL | 0.003~0.65 mL/min | Rc (8.4~190) | 80 |
Symmetric serpentine Right-angled bend | 200×40 | PS (8,9.9,13) | 0.025~0.1%w/w | 0.59~1 mL/min | Rc (118~200) | 88 |
Symmetric serpentine | (200~300)×(50~110) δ (250~375) | PS (5,10,13,15,20) | 0.05~0.1%w/v | 0.1~2 mL/min | De (5~110) | 92 |
Asymmetric serpentine+ straight rectangle | I: 100×5 (min.) II: 30×50 | PS (10.2) | 0.1% w/v | 0.0033~0.1 mL/min | Rp (0.2~6.0) | 17 |
isosceles triangle; Semicircle | w(50,80) h (40) Dia (50) h (40) | PS (7,9.9) | 0.05~0.1% w/w | - | Rp (0.008~3.2) | 79 |
Straight + straight | I: 50×25 II: 50×10 | PS (10,15,20) | 0.1%v/v | 0.15~0.21 mL/min | Rc (2.6~78) | 114 |
Symmetric serpentine | 350×91 δ: 800 | PS (10,15,20) | 0.01 wt% | 0.4~2.7 mL/min | Rc (30~205) | 93 |
Asymmetric serpentine | 20×10(min.) | PS (0.92,2) | 0.01~1%v/v | 0.01~1.4 mL/min | Rc (11.1~1550) | 99 |
Spiral rectangular | 250×50(min.) δ: 1440 (min.) | PS (2,7,10) | 0.1% w/v | 2~3.5 mL/min | De (0~30) | 102 |
Spiral rectangular | 150×50 | PS (5,10) | 0.5 wt% | - | De (0.86~15.53) | 107 |
Spiral rectangular | 500×130 | PS (10,15,20) | 0.1~0.3% v/v | 0.92~3 mL/min | De (4.4~14.6) | 67 |
Spiral trapezoidal | 600×80, 600×140 | PS(5.8,9.8,15.5,26.3) | - | 0.5~8 mL/min | - | 82 |
Spiral rectangular | 150×50 | PS (0.2~20) | - | 0.1~0.7 mL/min | De (1.73-12.08) | 109 |
Spiral rectangular | 160×50 | PS (2.1,4.8) | ~0.015%v/v | - | De (0.31-4.58) | 108 |
Spiral :micro-obstacles | 900×100 | PS (7.3,9.9,15.5) | - | 1.5~5.25 mL/min | Rc (0-666.7) | 112 |
Semi-circular and serpentine curve | 100×50 | PS (2.2,4.8,9.9) | 0.1%w/w | 0.05 mL/min 0.005 mL/min·s-1 | Rc (10-470) | 36 |
Curve and spiral | 100×50 | PS (4.4,9.9,15) | 0.021-0.23%v/v | - | Rc (0-400) | 113 |
Straight+semicircular | 69×92 | PS (5,7.3,10.4, 15.5,20.3) | ~105/mL | 0.2~1.5 mL/min | - | 37 |
Reverse wavy curved | 125×40 | PS (1,3,5,7,10,15) | 6×106/mL | 0.049~0.198 mL/min | Rc (10-40) | 100 |
Straight rectangular: Obstacle Arrays | h: 39 | PS (6,10,15) | - | 0.001~0.004 mL/min | - | 118 |
Stepped Straight | 81×41.5,21×81 | PS (7.9,9.9,13) | 0.1%w/w | - | Rc~ 83.33 | 120 |
Straight Square+ rectangular(pillars) | 100×100, 320×100,50×100 | PS (9.9,15,19) | 0.05~0.5%w/w | 0~0.8 mL/min | Rc~ 66.7 | 119 |
Straight rectangular expansion | 40×50,200×50 | PS (7) | 0.25%v/v | 0.010~0.2 mL/min | Rp (0.8-3.5) | 39 |
Straight with triangular expansion | 50×70 | PS(3.2,4.8,9.9) | ~105/mL | 0.05~0.7 mL/min | Rc(20.82-329.12) | 124 |
Stepped straight | 200×40 | PS(9.9,13,24) | (0.5~2)×105/mL | 0.2~1.5 mL/min | Rc (29.2-218.7) | 122 |
Spiral rectangular | 100×30,24×10,10×1.4 | PS(10,3,1,0.44) | 107~105/mL | 0.05~0.2 mL/min | - | 104 |
Channel structure | Channel dimension | Viscoelastic medium | Particle (a in μm) | Flow rate | Dimensionless number | ref |
---|---|---|---|---|---|---|
Straight square | 50×50 | 500 ppm PEO | PS(5.9) | 40~200 μL/h | El (3.21~21.5) Wi (1.61~8.04) | 126 |
Spiral rectangular | 100×25 | 500~5000 ppm PEO | PS(1.5,5,10) | 50~750 μL/h | De(2.4~18) | 68 |
Spiral rectangular | 215×50 AR(1/4~1/2) | 6.8 wt% PVP 500 ppm PEO | PS(10) | 1~240 μL/min | Rc (0.04~9.66) Wi (0.17~47.80) De (0.06~1.407) | 147 |
Straight with square expansion | 50×50+150×50 | 6.8 wt% PVP | PS(6) | 0.12~1 mL/h | Wi (0~5.8) | 141 |
Straight circular | φ50~φ181 | 0.05 wt% PEO, 8 wt% PVP | PS(5,10) | 1~120 μL/min | Wi(0.1~2.6) Rc(0.002~0.087) | 136 |
Straight square | 80×80 | 0.1% w/v HA | PS(1,3,6,8) | 0.6~50 mL/min | Wi (2.6~566) | 32 |
Straight with triangular expansion | 100×50 | 500 ppm PEO | PS(3.2,4.8,13) | 10~240 μL/min | Wi (22.74~181.92) Rc (2.31~18.48) | 142 |
Straight rectangular | h=50 AR(1/3~1) | 0.05 wt% PEO 8 wt % PVP | PS(2,5,10) | 1~180 μL/min | Rc(0~31.71)Wi (0~97.07) | 134 |
Straight square | 5×5 +5×50 | 500 ppm PEO | PS(0.1,0.2,0.5,1,2.4) | 5~15 μL/h | Wi (178~533)Rc (0.11~0.33) | 69 |
Straight rectangular | h=25,AR(1/4-1/1) | 500~4000 ppm PEO | PS(6.4,10,15) | 0.05~0.6 mL/h | Rc (0.35~30.07) Wi (1.668~57.715) | 140 |
Spiral rectangular | 140×50 | 2.0~8.0 wt% PVP | PS(10) | 10~60 μL/h | Rc (0.012~0.076)Wi (0.74~4.44) | 149 |
Multi-curvature serpentine | 125×40 | 0.001~0.1wt%PEO | PS(0.3,2,3,5,7,10,15) | 49.41~197.60 μL/min | Rc(6.52~39.84) Wi(0.74~2.96) | 148 |
Straight square | 50×50 | 0.01~1 wt% PEO | PS(4.8) | 40~320 μL/h | Wi (0.09~25.6)Rc(0.1~0.8) | 131 |
Straight square and trapezoid | 75×75 | 2000 ppm PEO | PS(3,5,10) | 1~250 μL/min | - | 135 |
Straight square | 50×50 | 6.6 wt% PVP | PS(6) | 0.02~0.16 mL/h | Wi (0.20)Rc (0.0007) | 146 |
Straight square | 50×50 | 2.5~50 ppm λ-DNA | PS(6,10,15) | 0.04~3 mL/h | Wi (99.4~1491)Rc (0.71~10.6) | 138 |
Straight rectangular | 80×12 | 1% w/v PEO | PS(0.02,0.04 0.1,0.2,0.5) | - | Wi (1.3~3.25)Rc(0.00017~0.65) | 145 |
double spiral | 30×4 | 0.2~0.6 wt% PEO | PS(0.05,0.075,0.1,0.2,0.5,1,2) | 0.32~2.45 μL/h | Wi (0.09~0.67) | 150 |
Application | Sample | Channel type | Optimum performance | ref |
---|---|---|---|---|
Cancer cell speparation from blood | Blood without diluted, hematocrit ~45% | Contraction-expansion array | Recovery: ~99.7% Throughput: 1.1×108cells/min | 155 |
CTCs speparation from blood | Blood, 2~2.5× diluted | spiral | Recovery: ~80% Throughput: 3mL/h | 33 |
Cancer cell speparation from blood | Blood, 50× diluted | Spiral | Recovery:~73.75% Throughput: 2 mL/min | 156 |
Extraction of plasma from blood | Blood, 20× diluted | Serpentine | Recovery:~99.75% Throughput: 350 μL/min | 157 |
Separation of microalgae from bacteria | Chlorella and Bacillus Subtilis mixtures | Straight contraction- expansion array | efficiency: 100% Throughput: 1μL/min | 160 |
Exosome sorting | MCF-7 cell medium | Wavy Serpentine | Recovery: ~81% Throughput: 25μL/min | 34 |
Bacteria separation from blood | Whole blood | Straight rectangular | Recovery: ~81% Throughput: 60μL/h | 161 |
Exosome sorting | Cell culture media | Straight rectangular | Recovery: ~80% Throughput: 200μL/h | 30 |
Rare tumer cell separation from blood | Untreated whole blood | Straight rectangular | Efficiency: ~95% Throughput: 9mL/h | 164 |
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