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化学进展 2013, Vol. 25 Issue (09): 1594-1600 DOI: 10.7536/PC130720 前一篇   后一篇

• 癌症化学预防专辑 •

增生平用于口腔癌化学预防

王嫣*1, 尤明2   

  1. 1. Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA;
    2. Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
  • 收稿日期:2013-01-22 出版日期:2013-09-25 发布日期:2013-07-31
  • 通讯作者: 王嫣 E-mail:wangyi@wustl.edu
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Chemoprevention of Oral Cancer by a Mixture of Chinese Herbs (Anti-Tumor Mixture B)

Wang Yian*1, You Ming2   

  1. 1. Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA;
    2. Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
  • Received:2013-01-22 Online:2013-09-25 Published:2013-07-31

增生平(ZSP,又称anti-tumor B,ATB)是一种由山豆根、拳参、北败酱、夏枯草、白鲜皮、黄药子等组成的中药复方。以前的研究显示增生平对人食管癌(主要是鳞状细胞癌)有显著的化学预防效用。我们系统地研究评价了增生平对4-硝基喹啉-1-氧化物诱导的A/J 小鼠口腔癌发生发展的影响,发现增生平减少了约60% 的口腔癌。对7,12-二甲苯并(a)蒽诱导的仓鼠口腔癌也观察到了类似的结果。进而在口腔白斑患者中开展了一个随机临床实验,结果发现增生平(每日三次,每次4 片,持续8—12 个月)在68% 的患者中减少了口腔病变的大小,而在安慰剂组只有17%(P<0.01)。这些结果显示增生平可能是一种强效的人口腔癌化学预防试剂。

关键词： 增生平, 中药复方, 动物模型, 口腔癌, 口腔白斑

Anti-tumor B (ATB) is a Chinese herbal mixture of six plants (Sophora tonkinensis, Polygonum bistorta, Prunella vulgaris, Sonchus brachyotus, Dictamnus dasycarpus and Dioscorea bulbifera). ATB is also called Zeng Sheng Ping (ZSP). Previous studies have shown significant chemopreventive efficacy of ATB against human esophageal cancer, mostly squamous cell carcinomas. The chemopreventive effects of ATB on the development of 4-nitroquinoline-1-oxide (4NQO) induced oral squamous cell carcinomas in A/J mice were systematically evaluated and it was found that ATB reduced 4NQO-induced oral cancer development by approximately 60%. Similar results were also seen in 7,12-dimethylbenz(a)anthracene (DMBA) induced oral cancer in hamsters. A randomized clinical trial was conducted in patients with oral leukoplakia. Treatment with ATB (4 tablets, 3 times per day for 8—12 months) reduced the size of oral lesions in 68% of the patients versus 17% of the patients in the placebo control group (P < 0.01). These results indicate that ATB may be a potent chemopreventive agent against the development of oral cancer in humans.

Key words: antitumor B, Chinese herbal mixture, animal models, oral cancer, oral leukoplakia

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增生平用于口腔癌化学预防