English
新闻公告
More
化学进展 2013, Vol. 25 Issue (09): 1526-1543 DOI: 10.7536/PC130717 前一篇   后一篇

• 癌症化学预防专辑 •

食用植物成分和中药用于癌症化学预防:Nrf2,表观基因组学,癌症干细胞

苏正元1, 舒利民1, Jong Hun Lee1,2, Franciso Fuentes1, 王虎1, 吴天元3, 余四旺1, Ah-Ng Tony Kong1*   

  1. 1. Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest-Mario School ofPharmacy, Rutgers, the State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA;
    2. Departamento de Agricultura del Desierto y Biotecnología, Universidad Arturo Prat, Casilla 121, Iquique, Chile;
    3. 北京大学医学部药学院化学生物学系 北京100190 中国
  • 收稿日期:2013-01-30 出版日期:2013-09-25 发布日期:2013-07-31
  • 通讯作者: Ah-Ng Tony Kong E-mail:KongT@pharmacy.rutgers.edu

Perspective on Nrf2, Epigenomics and Cancer Stem Cells in Cancer Chemoprevention Using Dietary Phytochemicals and Traditional Chinese Medicines

Zheng-Yuan Su1, Limin Shu1, Jong Hun Lee1,2, Franciso Fuentes1, Hu Wang1, Tien-Yuan Wu3, Siwang Yu1,Ah-Ng Tony Kong1*   

  1. 1. Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA;
    2. Departamento de Agricultura del Desierto y Biotecnología, Universidad Arturo Prat, Casilla 121, Iquique, Chile;
    3. Departament of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100190, China
  • Received:2013-01-30 Online:2013-09-25 Published:2013-07-31
  • Contact: Ah-Ng Tony Kong E-mail:KongT@pharmacy.rutgers.edu

癌症是世界范围内的首要致死原因之一。现代诊断和治疗技术的革新改善了癌症患者的治疗和护理,但晚期癌症的治疗仍然是一个巨大的挑战。因此,亟需新的创造性的策略来防治癌症。几个世纪以来,草药曾被用于防治癌症等疾病。科研资助机构,例如美国的国家癌症研究所(NCI),在近期加强了对利用天然植物成分和非毒性药物如非甾体抗炎药(NSAIDs)预防或减缓癌症发生研究的支持。本文综述了利用来源于蔬果、绿茶和中药的生物活性成分来预防癌症方面的研究,尤其是重点讨论了在Nrf2、表观基因组学和癌症干细胞等方面的影响。

Cancer is one of the leading causes of death worldwide. The innovation of modern diagnostics and chemotherapeutics has improved cancer patients' treatment and care, but advanced stages of cancer remain extremely challenging to treat. Therefore, new and creative approaches are needed to prevent and treat cancer. Herbal medicines have been used for many centuries to prevent diseases such as cancer. Funding agencies, such as the National Cancer Institute in the United States, have recently emphasized support for cancer chemoprevention research using natural phytochemicals and non-toxic drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) to prevent or delay the onset of cancer. This perspective distills the latest in cancer chemoprevention research using bioactive components from fruits, vegetables, green tea and Traditional Chinese Medicines (TCM), focusing on Nrf2, epigenomic and cancer stem cell effects.

中图分类号: 

()

[1] 朱晟(Zhu S),何端生(He D S). 中药简史(A Brief History of Traditional Chinese Medicine),桂林:广西师范大学出版社 (Guilin: Guangxi Normal University Press), 2007
[2] Wang H, Khor T O, Shu L, Su Z Y, Fuentes F, Lee J H, Kong A N. Anticancer Agents Med. Chem., 2012, 12(10):1281—1305
[3] Gutheil W G, Reed G, Ray A, Dhar A. Curr. Pharm. Biotechnol., 2011, 13(1):173—179
[4] Singh S V, Warin R, Xiao D, Powolny A A, Stan S D, Arlotti J A, Zeng Y, Hahm E R, Marynowski S W, Bommareddy A, Desai D, Amin S, Parise R A, Beumer J H, Chambers W H. Cancer Res., 2009, 69(5): 2117—2125
[5] Meeran S M, Ahmed A, Tollefsbol T O. Clin. Epigenetics, 2010, 1(3/4): 101—116
[6] Karikas G A. J. Buon., 2010, 15(4): 627—638
[7] Saunders FR, Wallace HM. Plant Physiol. Biochem., 2010, 48(7): 621—626
[8] Sarkar F H, Li Y, Wang Z, Padhye S. Curr. Pharm. Des., 2010, 16(16): 1801—1812
[9] Mehta R G, Murillo G, Naithani R, Peng X. Pharm. Res., 2010, 27(6): 950—961
[10] Gullett N P, Ruhul Amin A R, Bayraktar S, Pezzuto J M, Shin D M, Khuri F R, Aggarwal B B, Surh Y J, Kucuk O. Semin. Oncol., 2010, 37(3): 258—281
[11] Chen J, Xu X. Adv. Genet., 2010, 71: 237—255
[12] Huang W Y, Cai Y Z, Zhang Y. Nutr. Cancer, 2010, 62(1):1—20
[13] Huang J, Plass C, Gerhauser C. Curr. Drug Targets, 2011, 12(13): 1925—1956
[14] Shu L, Cheung K L, Khor T O, Chen C, Kong A N. Cancer Metastasis Rev., 2010, 29(3): 483—502
[15] Miller P E, Snyder D C. Nutr. Clin. Pract., 2012, 27(5): 599—612
[16] You L, An R, Liang K, Wang X. Mini. Rev. Med. Chem., 2012, 13(1):101—105
[17] Yang G, Li X, Li X, Wang L, Li J, Song X, Chen J, Guo Y, Sun X, Wang S, Zhang Z, Zhou X, Liu J. Evid. Based Complement Alternat. Med., 2012, 2012: 751046
[18] Man S, Gao W, Wei C, Liu C. Phytother. Res., 2012, 26(10): 1449—1465
[19] Smith M E, Bauer-Wu S. Semin. Oncol. Nurs., 2012, 28(1): 64—74
[20] Wang S, Wu X, Tan M, Gong J, Tan W, Bian B, Chen M, Wang Y. J. Ethnopharmacol., 2012, 140(1): 33—45
[21] Wang S, Penchala S, Prabhu S, Wang J, Huang Y. Curr. Drug Discov. Technol., 2010, 7(1): 67—75
[22] Parekh H S, Liu G, Wei M Q. Mol. Cancer, 2009, 8: 21
[23] Huang Z J, Zeng Y, Lan P, Sun P H, Chen W M. Mini. Rev. Med. Chem., 2011, 11(13): 1122—1129
[24] Zhou Q, Liu L, Zhang D, Fan X. Pharmazie, 2012, 67(10):844—847
[25] Marques F Z, Markus M A, Morris B J. Int. J. Biochem. Cell Biol., 2009, 41(11): 2125—2128
[26] Whitlock N C, Baek S J. Nutr. Cancer, 2012, 64(4): 493—502
[27] Sun M, Cao H, Sun L, Dong S, Bian Y, Han J, Zhang L, Ren S, Hu Y, Liu C, Xu L, Liu P. Evid. Based Complement Alternat Med., 2012, 2012: 373219
[28] Patisaul H B, Jefferson W. Front Neuroendocrinol, 2010, 31(4): 400—419
[29] Al-Azzawi F, Wahab M. Ann. N. Y. Acad. Sci., 2010, 1205: 262—267
[30] Nag S A, Qin J J, Wang W, Wang M H, Wang H, Zhang R. Front Pharmacol., 2012, 3: 25
[31] Hutchins—Wolfbrandt A, Mistry A M. Asian Pac. J. Cancer Prev., 2011, 12(12): 3169—3173
[32] Sertel S, Eichhorn T, Bauer J, Hock K, Plinkert P K, Efferth T. J. Nutr. Biochem., 2012, 23(8): 875—884
[33] Kim J W, Amin A R, Shin D M. Cancer Prev. Res. (Phila), 2010, 3(8): 900—909
[34] Pan M H, Lai C S, Wu J C, Ho C T. Mol. Nutr. Food Res., 2011, 55(1): 32—45
[35] Olejnik A, Tomczyk J, Kowalska K, Grajek W. Postepy. Hig. Med. Dosw., (Online), 2010, 64: 175—187
[36] Riscuta G, Dumitrescu R G. Methods Mol. Biol., 2012, 863: 343—358
[37] Guo Z, Jia X, Liu J P, Liao J, Yang Y. Cochrane Database Syst. Rev., 2012, 5: CD004653
[38] Callahan R, Hurvitz S. Curr. Opin. Obstet. Gynecol., 2011, 23(1): 37—43
[39] Bishayee A, Ahmed S, Brankov N, Perloff M. Front Biosci., 2011, 16: 980—996
[40] Rahman M A, Amin A R, Shin D M. Nutr. Cancer, 2010, 62(7): 973—987
[41] Wei X, Chen Z, Yang X, Wu T. Cochrane Database Syst. Rev., 2009, (4): CD004520
[42] Stan S D, Singh S V, Brand R E. Nat. Rev. Gastroenterol. Hepatol., 2010, 7(6): 347—356
[43] Leung P S. Common Pancreatic Disease. Adv. Exp. Med. Biol., 2010, 690: 29—51
[44] Trottier G, Bostrom P J, Lawrentschuk N, Fleshner N E. Nat.Rev. Urol., 2010, 7(1): 21—30
[45] Hu R, Saw C L, Yu R, Kong A N. Antioxid Redox Signal, 2010, 13(11): 1679—1698
[45] Lee S E, Jeong S I, Yang H, Jeong S H, Jang Y P, Park C S, Kim J, Park Y S. Journal of Ethnopharmacology, 2012, 139(2): 541—548
[47] Cerella C, Sobolewski C, Dicato M, Diederich M. Biochem. Pharmacol., 2010, 80(12): 1801—1815
[48] Li-Weber M. Cancer Lett., 2010, 332(2):304—312
[49] Wu M, Yao B. J. Tradit. Chin. Med., 2002, 22(4): 303—307
[50] Jeong S J, Koh W, Lee E O, Lee H J, Lee H J, Bae H, Lü J, Kim S H. Phytother. Res., 2011, 25(1): 1—10
[51] 奚胜艳(Xi S Y), 王彦晖(Wang Y H), 赵育芳(Zhao Y F), 卢大为(Lu D W), 李鹏程(Li P C), 张前(Zhang Q). 中国中药 杂志(China Journal of Chinese Materia Medica), 2010, 35(10): 1352—1356
[52] WHO. The 10 Leading Causes of Death by Broad Income Group (2008), 2011. [2013-01-017] http://who.int/mediacentre/factsheets/fs310/en/index.html
[53] Xu J K K, Murphy S L, Tejada-Vera B. Deaths: Final Data for 2007. National Vital Statistics Reports; vol 58 no 19. Hyattsville M D: National Center for Health Statistics. 2010
[54] Armitage P. Environ. Health Perspect., 1985, 63: 195—201
[55] Hussain S P, Harris C C. Int. J. Cancer, 2007, 121(11): 2373— 2380
[56] Moolgavkar S H. J. Natl. Cancer Inst., 1978, 61(1): 49—52
[57] Li L C, Carroll P R, Dahiya R. Journal of the National Cancer Institute, 2005, 97(2): 103—115
[58] Hanahan D, Weinberg R A. Cell, 2000, 100(1): 57—70
[59] Wattenberg L W. Cancer Research, 1985, 45(1): 1—8
[60] Lee J H, Khor T O, Shu L, Su Z Y, Fuentes F, Kong A N. Pharmacology & Therapeutics, 2013, 137(2): 153—171
[61] Surh Y J. Nat. Rev. Cancer, 2003, 3(10): 768—780
[62] Kong A N, Yu R, Lei W, Mandlekar S, Tan T H, Ucker D S. Restorative Neurology and Neuroscience, 1998, 12(2/3):63—70
[63] Li LY, Luo X, Wang X. Nature, 2001, 412(6842): 95—99
[64] Wang X. Genes Dev., 2001, 15(22): 2922—2933
[65] Jiang X, Wang X. Annu. Rev. Biochem., 2004, 73: 87—106
[66] Lemasters J J, Theruvath T P, Zhong Z, Nieminen A L. Biochimica et Biophysica Acta, 2009, 1787(11): 1395—1401
[67] Danial N N, Korsmeyer S J. Cell, 2004, 116(2): 205—219
[68] Dejean L M, Martinez-Caballero S, Manon S, Kinnally KW. Biochimica et Biophysica Acta, 2006, 1762(2): 191—201
[69] Scorrano L, Oakes SA, Opferman J T, et al. Science, 2003, 300(5616): 135—139
[70] Ashkenazi A, Dixit V M. Science, 1998, 281(5381): 1305—1308
[71] Sprick M R, Walczak H. Biochim. Biophys. Acta, 2004, 1644(2/3): 125—132
[72] Wajant H. Science, 2002, 296(5573): 1635—1636
[73] Ashkenazi A. Cytokine Growth Factor Rev., 2008, 19(3/4): 325—331
[74] Barnhart B C, Peter M E. Cell, 2003, 114(2): 148—150
[75] Kischkel F C, Hellbardt S, Behrmann I, et al. EMBO J., 1995, 14(22): 5579—5588
[76] Kischkel F C, Lawrence D A, Chuntharapai A, Schow P, Kim K J, Ashkenazi A. Immunity, 2000, 12(6): 611—620
[77] Mace T A, Yamane N, Cheng J, Hylander B L, Repasky E A. Immunol. Invest., 2006, 35(3/4): 279—296
[78] Ashkenazi A. Nat. Rev. Cancer, 2002, 2(6): 420—430
[79] Naka T, Sugamura K, Hylander B L, Widmer M B, Rustum Y M, Repasky E A. Cancer Res., 2002, 62(20): 5800—5806
[80] Ravi R, Bedi A. Cancer Res., 2002, 62(6): 1583—1587
[81] Clarke N, Nebbioso A, Altucci L, Gronemeyer H. Cell Cycle, 2005, 4(7): 914—918
[82] Zhang L, Ren X, Alt E, et al. Nature, 2010, 464(7291): 1058—1061
[83] Lee D H, Rhee J G, Lee Y J. Br. J. Pharmacol., 2009, 157(7): 1189—1202
[84] Wicker C A, Sahu R P, Kulkarni-Datar K, Srivastava S K, Brown T L. Cancer Growth Metastasis, 2010, 2009(2): 45—55
[85] Tian H, Zhang B, Di J, et al. Cancer Lett., 2012, 325(1): 26—34
[86] Johnson I T. Proc. Nutr. Soc., 2007, 66(2): 207—215
[87] Miao W, Hu L, Scrivens P J, Batist G. J. Biol. Chem., 2005, 280(21): 20340—20348
[88] Giudice A, Arra C, Turco M C. Methods Mol. Biol., 2010, 647: 37—74
[89] McMahon M, Itoh K, Yamamoto M, Chanas S A, Henderson C J, McLellan L I, Wolf C R, Cavin C, Hayes J D. Cancer Res., 2001, 61(8): 3299—3307
[90] Rushworth S A, MacEwan D J, O'Connell M A. J. Immunol., 2008, 181(10): 6730—6737
[91] Sun Z, Wu T, Zhao F, Lau A, Birch C M, Zhang D D. Mol. Cell Biol., 2011, 31(9): 1800—1811
[92] Moi P, Chan K, Asunis I, Cao A, Kan Y W. Proc. Natt. Acad. Sci. U. S. A., 1994, 91(21): 9926—9930
[93] Chan J Y, Cheung M C, Moi P, Chan K, Kan Y W. Human Genetics, 1995, 95(3): 265—269
[94] Zhang D D. Drug Metabolism Reviews, 2006, 38(4): 769—789
[95] Lin W, Shen G, Yuan X, Jain M R, Yu S, Zhang A, Chen J D, Kong A N. J. Biochem. Mol. Biol., 2006, 39(3): 304—310
[96] Tong K I, Padmanabhan B, Kobayashi A, Shang C, Hirotsu Y, Yokoyama S, Yamamoto M. Mol. Cell Biol., 2007, 27(21): 7511—7521
[97] Copple I M, Goldring C E, Kitteringham N R, Park B K. Handb. Exp. Pharmacol., 2010, (196): 233—266
[98] Cullinan S B, Gordan J D, Jin J, Harper J W, Diehl J A. Mol. Cell Biol., 2004, 24(19): 8477—8486
[99] Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel J D, Yamamoto M. Genes & development, 1999, 13(1): 76—86
[100] Li W, Kong A N. Mol. Carcinog., 2009, 48(2): 91—104
[101] Dinkova-Kostova A T, Holtzclaw W D, Cole R N, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P. Proc. Natl. Acad. Sci. U. S. A., 2002, 99(18): 11908—11913
[102] Dinkova-Kostova A T, Holtzclaw W D, Wakabayashi N. Biochemistry, 2005, 44(18): 6889—6899
[103] Venugopal R, Jaiswal A K. Proc. Natl. Acad. Sci. U. S. A., 1996, 93(25): 14960—14965
[104] Hayes J D, Chanas S A, Henderson C J, McMahon M, Sun C, Moffat G J, Wolf C R, Yamamoto M. Biochemical Society Transactions, 2000, 28(2): 33—41
[105] Nguyen T, Nioi P, Pickett C B. J. Biol. Chem., 2009, 284(20): 13291—13295
[106] Kundu J K, Surh Y J. Pharm. Res., 2010, 27(6): 999—1013
[107] Chanas S A, Jiang Q, McMahon M, McWalter G K, McLellan L I, Elcombe C R, Henderson C J, Wolf C R, Moffat G J, Itoh K, Yamamoto M, Hayes J D. Biochem. J., 2002, 365(Pt 2): 405—416
[108] Li W, Khor T O, Xu C, Shen G, Jeong W S, Yu S, Kong A N. Biochem. Pharmacol., 2008, 76(11): 1485—1489
[109] Malhotra D, Portales-Casamar E, Singh A, Srivastava S, Arenillas D, Happel C, Shyr C, Wakabayashi N, Kensler T W, Wasserman W W, Biswal S. Nucleic Acids Res., 2010, 38(17): 5718—5734
[110] Boutten A, Goven D, Artaud-Macari E, Boczkowski J, Bonay M. Trends Mol. Med., 2011, 17(7): 363—371
[111] Kim J, Cha Y N, Surh Y J. Mutat. Res., 2010, 690(1/2): 12—23
[112] Alam J, Stewart D, Touchard C, Boinapally S, Choi A M, Cook J L. J. Biol. Chem., 1999, 274(37): 26071—26078
[113] Ishii T, Itoh K, Sato H, Bannai S. Free Radic. Res., 1999, 31(4): 351—355
[114] Paine A, Eiz-Vesper B, Blasczyk R, Immenschuh S. Biochem. Pharmacol., 2010, 80(12): 1895—1903
[115] Jun C D, Kim Y, Choi E Y, Kim M, Park B, Youn B, Yu K, Choi K S, Yoon K H, Choi S C, Lee M S, Park K I, Choi M, Chung Y, Oh J. Inflamm. Bowel. Dis., 2006, 12(7): 619—629
[116] Das K C. J. Biol. Chem., 2001, 276(7): 4662—4670
[117] Yu M, Li H, Liu Q, Liu F, Tang L, Li C, Yuan Y, Zhan Y, Xu W, Li W, Chen H, Ge C, Wang J, Yang X. Cell Signal, 2011, 23(5): 883—892
[118] Kim J E, You D J, Lee C, Ahn C, Seong J Y, Hwang J I. Cell Signal, 2010, 22(11): 1645—1654
[119] Lin H, Liu J, Zhang Y. Frontiers of Medicine, 2011, 5(2): 127—133
[120] Hsiao W L, Liu L. Planta. Medica., 2010, 76(11): 1118—1131
[121] Park E J, Zhao Y Z, Kim Y C, Sohn D H. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 2009, 47(11): 2742—2748
[122] Tang S Y, Wang H, Zhang W, Halliwell B. Chemical Research in Toxicology, 2008, 21(12): 2414—2423
[123] Dietz B M, Liu D, Hagos G K, Yao P, Schinkovitz A, Pro S M, Deng S, Farnsworth N R, Pauli G F, van Breemen R B, Bolton J L. Chemical Research in Toxicology, 2008, 21(10): 1939—1948
[124] Chu Q, Hashimoto K, Satoh K, Wang Q, Sakagami H. In Vivo, 2009, 23(4): 537—544
[125] Chiu P Y, Leung H Y, Siu A H, Poon M K, Dong T T, Tsim K W, Ko K M. Planta Medica, 2007, 73(2): 134—141
[126] Wen Z, Wang Z, Wang S, Ravula R, Yang L, Xu J, Wang C, Zuo Z, Chow M S, Shi L, Huang Y. PLoS One, 2011, 6(3): e18278
[127] Yang H L, Chen C S, Chang W H, Lu F J, Lai Y C, Chen C C, Hseu T H, Kuo C T, Hseu Y C. Cancer letters, 2006, 231(2): 215—227
[128] Ho C M, Huang C C, Huang C J, Cheng J S, Chen I S, Tsai J Y, Jiann B P, Tseng P L, Kuo S J, Jan C R. The Chinese Journal of Physiology, 2008, 51(2): 78—84
[129] Huang C C, Cheng H H, Wang J L, Cheng J S, Chai K L, Fang Y C, Kuo C C, Chu S T, Ho C M, Lin K L, Tsai J Y, Jan C R. The Chinese Journal of Physiology, 2009, 52(3): 128—135
[130] Won H J, Han C H, Kim Y H, Kwon H J, Kim B W, Choi J S, Kim K H. Journal of Ethnopharmacology, 2006, 106(3): 383—389

[1] 何静, 陈佳, 邱洪灯. 中药碳点的合成及其在生物成像和医学治疗方面的应用[J]. 化学进展, 2023, 35(5): 655-682.
[2] 黎钧耀. 癌症的营养干预研究[J]. 化学进展, 2013, 25(09): 1462-1479.
[3] 杨中枢. 维生素E和茶多酚用于癌症预防:动物模型和人群研究的体验[J]. 化学进展, 2013, 25(09): 1492-1500.
[4] 王秀君*, 李欣, 唐修文. Nrf2通路在肿瘤化学预防中的研究进展[J]. 化学进展, 2013, 25(09): 1544-1552.
[5] 郜嵩, Sumit Basu, 杨广义, Arijita Deb, 胡明. 天然产物用于癌症化学预防的口服生物利用度问题[J]. 化学进展, 2013, 25(09): 1553-1574.
[6] 王嫣, 尤明. 增生平用于口腔癌化学预防[J]. 化学进展, 2013, 25(09): 1594-1600.
[7] 陈洪章*, 彭小伟. 汽爆技术促进中药资源高值化利用[J]. 化学进展, 2012, (9): 1857-1864.
[8] 蔡宝昌, 秦昆明, 吴皓, 蔡皓, 陆兔林, 张兴德. 中药炮制过程化学机理研究[J]. 化学进展, 2012, 24(04): 637-649.
[9] 吴毓林. 青蒿素——历史和现实的启示[J]. 化学进展, 2009, 21(11): 2365-2371.
[10] 叶晓川,杨祥良,徐辉碧. 纳米雄黄研究进展[J]. 化学进展, 2009, 21(05): 934-939.
[11] 陈振锋,彭艳,谭明雄,刘延成,王恒山,梁宏. 基于中药活性成分的金属基抗肿瘤药物前期研究*[J]. 化学进展, 2009, 21(05): 929-933.
[12] 姚新生,叶文才,栗原博. 阐明中药科学内涵 推进中药现代化与创新药物研究进程[J]. 化学进展, 2009, 21(01): 2-13.
[13] 徐强,孙洋. 源于中药选择性效应的新型免疫抑制疗法[J]. 化学进展, 2009, 21(01): 55-62.
[14] 王锋鹏. 从草乌化学研究开发的新药思考中药现代化的方法[J]. 化学进展, 2009, 21(01): 63-65.
[15] 叶敏,果德安. 关于中药质量控制与体内代谢研究的思考[J]. 化学进展, 2009, 21(01): 100-105.