English
往期目录
新闻公告
More
化学进展 2009, Vol. 21 Issue (05): 919-928 前一篇   后一篇

• 金属药物专辑 •

从稀土对骨代谢的影响看稀土的药用及安全性*

张金超1,3**; 王鹏2; 孙静2; 刘翠莲1,3; 陈华1,3; 黄健4   

  1. （1.河北大学化学与环境科学学院化学生物学实验室   保定 071002; 2. 河北大学附属医院  保定 071000; 3. 河北大学药物化学与分子诊断教育部重点实验室   保定 071002; 4. 北京大学药学院化学生物学系   北京 100081）
  • 收稿日期:2008-12-22 修回日期:2009-01-27 出版日期:2009-05-24 发布日期:2009-05-05
  • 通讯作者: 张金超 E-mail:jczhang6970@yahoo.com.cn
  • 基金资助:

    国家自然科学基金

下载PDF ( 1711 ) 引用
导出

Viewing Safety of Rare-Earths-Based Drugs from Effect of Rare Earth on Bone Metabolism

Zhang Jinchao1,3**; Wang Peng2; Sun Jing2; Liu Cuilian1,3; Chen Hua1,3; Huang Jian4   

  1.  (1. Chemical Biology Laboratory, College of Chemistry & Enviromental Science, Hebei University, Baoding 071002, China; 2. Affiliated Hospital of Hebei University, Baoding 071000, China; 3. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, China; 4. Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China)
  • Received:2008-12-22 Revised:2009-01-27 Online:2009-05-24 Published:2009-05-05
  • Contact: Zhang Jinchao E-mail:jczhang6970@yahoo.com.cn

骨骼的正常代谢涉及多种金属离子，随着稀土的应用，通过环境和经由食物链等渠道进入人体内的稀土量也有所增加, 并且在骨组织中相对富集且难排出；由于稀土与钙离子的相似性，它们将干预和调控骨的形成与再造。一方面，稀土被设想可以用来作为治疗骨疾病的药物, 另一方面，它对骨代谢的影响产生负面作用。因此, 稀土的药用和安全性日益成为人们关注的问题。本文回顾了稀土离子对骨代谢影响的研究进展，探讨了其药用和安全性问题, 主要从以下三个方面进行综述: (1)稀土离子对成骨细胞细胞和破骨细胞的分化和功能表达的影响; (2)稀土离子对骨髓基质细胞成骨分化和成脂分化的影响; (3)稀土离子对动物骨矿物相的影响。此外，还指出了该研究领域的不足以及今后应该加强的研究方向。

关键词： 稀土离子, 骨代谢, 成骨细胞, 破骨细胞, 骨髓基质细胞

Some essential trace elements were reported to be involved in the normal bone metabolism. Nowadays rare earth elements are widely used in many fields and more and more rare earth elements enter the environment and food chains They are enriched in bone and difficult to be excreted. Because the similarity between rare earth ions (Ln3+) and Ca2+, they will intervene and regulate bone formation and remodeling. On one hand, rare earth are presumed to be drug candidates for bone disease; on the other hand, they have negative effects on bone metabolism. So the safety of rare-earth-based drugs deserves an answer. We review the effect of rare earth ions on bone metabolism as the following three aspects:(1)effect of rare earth ions on differentiation and function expression of osteoblasts and osteoclasts; (2)effect of rare earth ions on the osteogenic and adipogenic differentiation of bone marrow stromal cells; (3)effect of rare earth ions on bone mineral phase of animals. In addition, the scarcities and future developing perspectives in this field are also discussed.

Contents
1 Introduction
2 Effect of rare earth ions on differentiation and function expression of osteoblasts and osteoclasts
2.1 Effect of rare earth ions on differentiation and function expression of osteoblasts
2.2 Effect of rare earth ions on differentiation and function expression of osteoclasts
2.3 Effect of rare earth ions on bone resorption function of osteoclasts regulated by osteoblasts
3 Effect of rare earth ions on osteogenic and adipogenic differentiation of bone marrow stromal cells
4 Effect of rare earth ions on bone mineral phase of animals
5 Conclusion

Key words: rare earth ions, bone metabolism, osteoblasts, osteoclasts, bone marrow stromal cells

中图分类号: 

()

[ 1 ] 　Leek J C , Keen C L , Vogler J B , et al . Am. J . Clin. Nutr. ,1988 , 47 : 889 —895
[ 2 ] 　Saltman P D , Strause L G. J . Am. Coll . Nutr. , 1993 , 12 (4) :384 —389
[ 3 ] 　Moonga B S , Dempster D W. J . Bone Miner. Res. , 1995 , 10 (3) :453 —457
[ 4 ] 　李荣昌(Li R C) , 杨晓达(Yang X D) , 王夔(Wang K) 等. 中国稀土学报(J . Rare Earths) , 2004 , 22 (1) : 1 —6
[ 5 ] 　申治国(Shen Z G) , 钟广涛(Zhong G T) , 孔聘颜( Kong P Y) .中国卫生检验杂志( Chinese Journal of Health Laboratory Technology) , 2000 , 13 (1) : 43 —44
[ 6 ] 　杨频(Yang P) , 魏春英(Wei C Y) . 化学通报( Chemistry) ,1996 , 54 (1) : 14 —17
[ 7 ] 　Wang K. South Afr. J . Chem. , 1997 , 54 : 232 —239
[ 8 ] 　黄健(Huang J ) . 北京大学博士论文(Doctoral Dissertation of Peking University) ,2005
[ 9 ] 　Rodan GA , Martin TJ . Science , 2000 , 289 : 1508 —1514
[10 ] 　Teitelbaum S L. Science , 2000 , 289 : 1504 —1508
[11 ] 　Quarles L D , Hartle J E , Middleton J P , et al . J . Cell Biochem. ,1994 , 56 (1) : 106 —117
[12 ] 　Hartle J E , Prpic V , Siddhanti S R , et al . J . Bone Miner. Res. ,1996 , 11 (6) : 789 —799
[13 ] 　张金超(Zhang J C) , 李晓新(Li X X) , 许善锦(Xu SJ ) 等. 自然科学进展(Progress in Natural Science) , 2004 , 14 (4) : 404 —409
[14 ] 　Zhang D W, Zhang J C , Chen Y, et al . Progress in Natural Science ,2007 , 17 (5) : 618 —623
[15 ] 　Zhang J C , Xu S J , Wang K, et al . Chinese Sci . Bull . , 2003 , 48(20) : 2170 —2175
[16 ] 　Miyauchi A , Hruska K A , Greenfield E M, et al . J . Cell Biol . ,1990 , 111 (6) : 2543 —2552
[17 ] 　Shankar V S , Alam A S , Bax CM, et al . Biochem. Biophys. Res.Commun. , 1992 , 187 (2) : 907 —912
[18 ] 　Zhang J C , Huang J , Zhang TL , et al . J . Rare Earths , 2005 , 23(5) : 580 —583
[19 ] 　David J P , Neff L , Chen Y, et al . J . Bone Miner. Res. , 1998 , 13(11) : 1730 —1738
[20 ] 　Zhang J C , Zhang T L , Xu S J , et al . J . Rare Earths , 2004 , 22(6) : 891 —895
[21 ] 　Nicholson G C , Moseley J M, Sexton J M, et al . J . Clin. Invest . ,1986 , 78 (2) : 355 —360
[22 ] 　Rodan GA , Martin T J . Calcif . Tiss. Int . , 1981 , 33 (4) : 349 —351
[23 ] 　Zhang J C , Huang J , Zhang TL , et al . J . Rare Earths , 2005 , 23(4) : 496 —501
[24 ] 　Ahdjoudj S , Fromigue O , Marie P J . Histol . Histopathol . , 2004 ,19 : 151 —157
[25 ] 　Keila S , Pitaru S , Grosskopf A , et al . J . Bone Miner. Res. , 1994 ,9 (3) : 321 —327
[26 ] 　Maurin A C , Chavassieux PM, Frappart L , et al . Bone , 2000 , 26 :485 —489
[27 ] 　Ailhaud G, Grimaldi P , Negrel R. Annu. Rev. Nutr. , 1992 , 12 :207 —233
[28 ] 　Benayahu D , Zipori D , Wientroub S. Biochem. Biophys. Res.Commun. , 1993 , 197 (3) : 1245 —1252
[29 ] 　Kelly KA , Tanaka S , Baron R , et al . Endocrinol . , 1998 , 139 (4) :2092 —2101
[30 ] 　Sakaguchi K, Morita I , Murota S. Prostaglandins Leukotrienes and Essential Fatty Acids , 2000 , 62 (5) : 319 —327
[31 ] 　Benayahu D , Peled A , Zipori D. J . Cell Biochem. , 1994 , 56 :374 —384
[32 ] 　Nuttall M E , Gimble J M. Bone , 2000 , 27 (2) : 177 —184
[33 ] 　宋纯理(Song C L) , 党耕町(Dang G T) . 中国骨质疏松杂志(Chinese Journal of Osteoporosis) , 2002 , 8 (3) : 266 —269
[34 ] 　刘红梅(Liu H M) , 张天蓝(Zhang TL) , 许善锦(Xu S J ) 等.科学通报(Chinese Science Bulletin) ,2006 ,51 (1) : 28 —33
[35 ] 　Zhang J C , Liu D D , Sun J , et al . Chinese Sci . Bull . , 2009 , 54(1) : 66 —71
[36 ] 　Sakurai YA. J . Dent . Sci . , 1998 , 20 :1 —5
[37 ] 　Warring PM, Waltling RJ . Med. J . Aust . , 1990 , 153 : 726 —730
[38 ] 　Yumiko N , Yakari T, Yasuhide T, et al . Fundam. Appl . Toxicol . ,1997 , 37 : 106 —116
[39 ] 　Kazuo T S , Etsuko K, Yuzo I , et al . Toxicol . , 1992 , 76 : 141 —152
[40 ] 　Shinohara A , Chiba M, Inaba Y. Biomed. Res. Trace Elem. ,1993 , 4 (2) : 115 —116
[41 ] 　Suzuki S , Ogawa Y, Kisi Y, et al . Biomed. Res. Trace Elem. ,1991 , 2 (2) : 223 —234
[42 ] 　Jha A M, Singh A C. Mutation Res. , 1994 , 322 (3) : 169 —172
[43 ] 　李荣昌(Li R C) , 杨惠雯(Yang H W) , 王夔(Wang K) . 北京大学学报( 医学版) ( Journal of Peking University ( Health Sciences) ) ,2003 , 35 (6) : 622 —624
[44 ] 　Huang J , Zhang TL , Xu S J , et al . Calcif . Tissue Int . , 2006 , 78 :241 —247
[45 ] 　黄健(Huang J ) , 许善锦(Xu SJ ) , 卢景芬(Lu J F) 等. 中国稀土学报(J . Rare Earths) , 2001 , 19 (5) : 478 —480
[1] 杨频,薛绍武. 细胞无机化学研究中需要关注的几个方面[J]. 化学进展, 2004, 16(04): 667-.
[2] 魏春英,杨频. 稀土跨膜的荧光法与膜片钳法研究*[J]. 化学进展, 2002, 14(04): 246-.
[3] 杨频,杜会枝,薛绍武. 膜片钳在生命化学中的应用*[J]. 化学进展, 2002, 14(04): 251-.
[4] 杨斌盛,丰九英. 稀土等离子与铁生物调控[J]. 化学进展, 2002, 14(04): 287-.