English
新闻公告
More
化学进展 2005, Vol. 17 Issue (03): 417-422 前一篇   后一篇

• 综述与评论 •

类脂立方液晶作为药物载体的研究*

王志宁;郑利强**   

  1. 山东大学 胶体与界面化学教育部重点实验室 济南 250100
  • 收稿日期:2004-02-01 修回日期:2004-05-01 出版日期:2005-05-24 发布日期:2005-05-24
  • 通讯作者: 郑利强

Progress in Cubic Phase of Lipid Liquid Crystal as Drug Delivery System

Wang Zhining;Zheng Liqiang**   

  1. Key Laboratory for Colloid and Interface Chemistry of Ministry of Education,Shandong University,Jinan 250100,China
  • Received:2004-02-01 Revised:2004-05-01 Online:2005-05-24 Published:2005-05-24
  • Contact: Zheng Liqiang
综述了近年来类脂立方液晶作为药物载体的研究进展,特别是对甘油单油酸酯/水体系形成的立方液晶进行了详细的介绍和讨论;重点论述了类脂立方液晶的物理化学性质以及类脂立方液晶作为药物载体的特点和药物对相态的影响;同时还探讨了类脂立方液晶作为药物载体的应用前景.
The cubic liquid crystals of lipids used as drug delivery system are reviewed in this paper. The characterization of the lipid cubic phase and the influence of phase behavior on the drug delivery are also introduced in detail.

中图分类号: 

()

[ 1 ] 张阳德(Zhang Y D) , 龚连生(Gong L S) . 中国现代医学杂志(China Journal of Modern Medicine) , 2001 , 11 (3) : 1 —4
[ 2 ] 张阳德(Zhang Y D) , 龚连生(Gong L S) . 中国现代医学杂志(China Journal of Modern Medicine) , 2001 , 11 (3) : 4 —10
[ 3 ] 陆彬(Lu B) , 李凤前(Li F Q) . 药学学报(Acta Pharmaceutica Sinica) , 2000 , 35 (7) : 535 —538
[ 4 ] 王仁芝(Wang R Z) , 仲伟强(Zhong W Q) , 关首任( Guan S R) . 中华肿瘤杂志(Chinese Journal of Oncology) , 1994 , 16(2) : 98 —102
[ 5 ] 符乃阳(Fu N Y) , 张尔贤(Zhang E X) , 庞大本( Pang D B)等. 中国生物化学与分子生物学报( Chinese Journal of Biochemistry and Molecular Biology) , 2000 , 16 (2) : 275 —280
[ 6 ] 符乃阳(Fu N Y) , 马靖(Ma J ) , 张尔贤(Zhang E X) . 药物生物技术(Pharmaceutical Biotechnology) , 1997 , 4 (4) : 251 —256
[ 7 ] 江志强(Jiang Z Q) , 马远明(Ma Y M) . 中国生化医药杂志(Chinese Journal of Biochemical Pharmaceutics) , 1996 , 17 (4) :180 —184
[ 8 ] Britta S , Heike B , Miche H J K, et al . International Journal of Pharmaceutics , 2002 , 244 : 33 —43
[ 9 ] Leslie S B , Puvvada S , Ratna B R , et al . Biochimica Biophysica Acta , 1996 , 1285 : 246 —254
[10] Sadhale Y, Shah J C. International Journal of Pharmaceutics ,1999 , 191 : 65 —74
[11] Sadhale Y, Shah J C. International Journal of Pharmaceutics ,1999 , 191 : 51 —64
[12] Vandamme T F. Progress in Retinal and Eye Research , 2002 , 21 :15 —34
[13] Lawrece M J , Rees G D. Advanced Drug Delivery Reviews ,2000 , 45 : 89 —21
[14] Larsson K, Fontell K, Krog N. Chemistry and Physics of Lipids ,1980 , 27 (4) : 321 —328
[15] Ericsson B , Eriksson P O , Leofroth J E , et al . ACS Symp. Ser. ,1991 , 469 : 251 —265
[16] Luzzati V. X-Ray Diffraction Studies of Lipid2Water Systems.London : Academic Press , 1968. preface
[17] von Minden H M, Milkereit G, Vill V. Chemistry and Physics of Lipids , 2002 , 120 : 45 —56
[18] Boni L T, Hui S W. Biochimica et Biophysica Acta , 1983 , 731(2) : 177 —185
[19] Sjolund M, Lindblom G, Rilfors L , et al . Biophysical Journal ,1987 , 52 (2) : 145 —153
[20] Czeslik C , Winter R , Rapp G, et al . Biophysical Journal , 1995 ,68 (4) : 1423 —1429
[21] Gustafsson J , Ljusberg-Wahren H , Almgren M, et al . Langmuir ,1996 , 12 (20) : 4611 —4613
[22] Delacroix H. Journal of Microscopy , 1998 , 192 (3) : 280 —292
[23] Winter R , Erbes J , Templer R H , et al . Physical ChemistryP Chemical Physics , 1999 , 1 : 887 —893
[24] Heberle J , Buldt G, Koglin E , et al . Journal of Molecular Biology , 1998 , 281 (4) : 587 —592
[25] Puvvada S , Baral S , Chow G M, et al . Journal of the American Chemical Society , 1994 , 116 (5) : 2135 —2136
[26] Rama Krishna Y V , Marsh D. Biochimica et Biophysica Acta ,1990 , 1024 (1) : 89 —94
[27] Chung H , Caffrey M. Biophysical Journal , 1995 , 69 (5) : 1951 —1963
[28] Engstrêm S , Lindahl L , Wallin R , et al . International Journal of Pharmaceutics , 1992 , 86 (2/3) : 137 —145
[29] Eriksson P O , Lindblom G. Biophysical Journal , 1993 , 64 (1) :129 —136
[30] Takahashi H , Hatta I , Quinn P J . Biophysical Journal , 1996 , 70(3) : 1407 —1411
[31] Larsson K. Journal of Physical Chemistry , 1989 , 93 (21) : 7304 —7314
[32] Caffrey M. Journal of Structural Biology , 2003 , 142 : 108 —132
[33] Wyatt D M, Dorschel D. Pharmaceutical Technology , 1992 , 16(10) : 116 —130
[34] Engstrêm S , Nordén T P , Nyquist H. European Journal of Pharmaceutical Sciences , 1999 , 8 (4) : 243 —245
[35] Yoshio A N , Li S J , Masahito Y. Biochimica et Biophysica Acta ,1999 , 1461 : 96 —102
[36] Tardier L A , Luzzati V. Biochimica et Biophysica Acta , 1990 ,219 (1) : 11 —17
[37] Chung H , Caffrey M. Nature , 1994 , 368 : 224 —226
[38] von Schnering H G, Nesper R. Z. Phys. B : Condensed Matter ,1991 , 83 : 407 —412
[39] Larsson K. Current Opinion in Colloid and Interface Science ,2000 , 5 (1) : 64 —69
[40] Engstrêm S. ACS Polym. Prep. , 1990 , 31 (2) : 157 —158
[41] Esposito E , Carotta V , Scabbia A , et al . International Journal of Pharmaceutics , 1996 , 142 (1) : 9 —23
[42] Lindell K, EngblomJ , Jonstroemer M, et al . Progress in Colloid and Polymer Science , 1998 , 108 : 111 —118
[43] Sadhale Y, Shah J C. Pharmaceutical Development and Technology , 1998 , 3 (4) : 549 —556
[44] Geraghty P B , Attwood D , Collett J H , et al . Pharmaceutical Research , 1996 , 13 : 1265 —1271
[45] Norling T, Landing P , Engstrêm S , et al . Journal of Clinical Periodontology , 1992 , 19 : 687 —692
[46] Burrows R , Collett J H , Attwood D. International Journal of Pharmaceutics , 1994 , 111 (3) : 283 —293
[47] Chang C M, Bodmeier R. International Journal of Pharmaceutics ,1997 , 147 : 135 —142
[48] Borne J , Nylander T, Khan A. Langmuir , 2000 , 16 : 10044 —10054
[49] Clogston J , Rathman J , Tomasko D , et al . Chemistry and Physics of Lipids , 2000 , 107 (2) : 191 —220
[50] Perkins W R , Ahmad I , Li X, et al . International Journal of Pharmaceutics , 2000 , 200 (1) : 27 —29
[51] Murgia S , Caboi F , Monduzzi M. Chemistry and Physics of Lipids , 2001 , 110 : 11 —17
[52] Engstrêm S , Engstrêm L. International Journal of Pharmaceutics ,1992 , 79 : 113 —122
[53] Koynova R , Tenchov B. Current Opinion in Colloid and Interface Science , 2001 , 6 (3) : 277 —286
[54] Marsh D , Seddon J M. Biochimica et Biophysica Acta , 1982 ,690 : 117 —123
[55] Koynova R D , Tenchov B G, Quinn P J , et al . Chemistry and Physics of Lipids , 1988 , 48 : 205 —214
[56] Seddon J M, Hogan J L , Warrender N A. Progress in Colloid Polymer Science , 1990 , 81 : 189 —197
[57] Luzzati V. Current Opinion in Structural Biology , 1997 , 7 (5) :661 —668
[58] Koynova R D , Tenchov B , Rapp G. Chemistry and Physics of Lipids , 1997 , 88 : 45 —67
[59] Templer R H , Seddon J M, Warrender N A , et al . Journal of Physical Chemistry B , 1998 , 102 (37) : 7251 —7261
[60] Templer R H , Seddon J M, Duesing P M, et al . Journal of Physical Chemistry B , 1998 , 102 (37) : 7262 —7271
[61] Koynova R D , Boyanov A I , Tenchov B G. Biochimica et Biophysica Acta , 1987 , 903 (1) : 186 —196
[62] Tenchov B , Rappolt M, Koynova R , et al . Biochimica et Biophysica Acta , 1996 , 1285 (1) : 109 —122
[63] Gustafsson J , Nylander T, Almgren M, et al . Journal of Colloid and Interface Science , 1999 , 211 (2) : 326 —335
[64] Nielsen L S , Schubert L , Hansen J . European Journal of Pharmaceutical Sciences , 1998 , 6 (3) : 231 —239
[65] CalumJ D , Celesta F. Current Opinion in Colloid and Interface Science , 2000 , 4 (6) : 449 —456
[66] Shah J C , Sadhale Y, Chilukuri D M. Advanced Drug Delivery Reviews , 2001 , 47 : 229 —250
[67] Park E S , Maniar M, Shah J . Journal of Controlled Release ,1998 , 52 (1/2) : 179 —189
[68] Chang C M, Bodmeier R. International Journal of Pharmaceutics ,1997 , 147 (2) : 135 —142
[69] Puvvade S , Qadri S B , Naciri J , Ratna B R. Journal of Physical Chemistry , 1993 , 97 : 11103 —11107

[1] 宝利军, 危俊吾, 钱杨杨, 王雨佳, 宋文杰, 毕韵梅. 酶响应性线形-树枝状嵌段共聚物的合成、性能及应用[J]. 化学进展, 2022, 34(8): 1723-1733.
[2] 陈晓峰, 王开元, 梁芳铭, 姜睿祺, 孙进. 外泌体递药系统及其在肿瘤治疗中的应用[J]. 化学进展, 2022, 34(4): 773-786.
[3] 张芬铭, 田语舒, 郑绩, 陈堃, 冯岸超, 张立群. 基于PHPMA的生物医用功能高分子[J]. 化学进展, 2020, 32(2/3): 331-343.
[4] 英启炜, 廖建国, 吴民行, 翟智皓, 刘欣茹. 球形生物活性玻璃作为运输载体的研究[J]. 化学进展, 2019, 31(5): 773-782.
[5] 何天稀, 梁琼麟, 王九, 罗国安. 脂质体类药物载体的微流控制备[J]. 化学进展, 2018, 30(11): 1734-1748.
[6] 韩冬琳, 亓洪昭, 赵瑾, 龙丽霞, 任玉, 原续波. 增强纳米药物载体肿瘤内渗透分布的研究进展[J]. 化学进展, 2016, 28(9): 1397-1405.
[7] 付开乔, 张光彦, 蒋序林. 聚天冬酰胺衍生物药物/基因载体的合成和应用[J]. 化学进展, 2016, 28(8): 1196-1206.
[8] 廖荣强, 刘满朔, 廖霞俐, 杨波. 基于环糊精的智能刺激响应型药物载体[J]. 化学进展, 2015, 27(1): 79-90.
[9] 刘鹏, 邵学广, 蔡文生*. 准轮烷/轮烷在药物载体中的应用[J]. 化学进展, 2013, 25(05): 692-697.
[10] 屈阳, 李建波*, 任杰*. 温度敏感性药物载体及其在肿瘤热化疗中的应用[J]. 化学进展, 2013, 25(05): 785-798.
[11] 陈梦君, 杨万泰, 尹梅贞* . 纳米粒子的分类合成及其在生物领域的应用[J]. 化学进展, 2012, 24(12): 2403-2414.
[12] 尤树森, 杨万泰, 尹梅贞* . 刺激响应型功能聚合物的合成及应用[J]. 化学进展, 2012, 24(11): 2198-2211.
[13] 杨嬅嬿, 熊焕明*, 余绍宁* . 量子点给药载体研究进展[J]. 化学进展, 2012, 24(11): 2234-2246.
[14] 吴同浩, 王仲妮. 生物表面活性剂胆汁盐胶束化及相行为[J]. 化学进展, 2011, 23(01): 80-89.
[15] 任天斌, 冯玥, 董海青, 李兰, 李永勇. 生物医用类壳层可脱落纳米粒子[J]. 化学进展, 2011, 23(01): 213-220.