English
往期目录
新闻公告
More
化学进展 2004, Vol. 16 Issue (06): 1008- 前一篇   后一篇

• 综述与评论 •

可注射水凝胶的制备与应用*

魏宏亮;王连才;张爱英;朱凯强;冯增国**   

  1. 北京理工大学材料科学与工程学院
  • 收稿日期:2003-10-01 修回日期:2004-01-01 出版日期:2004-11-24 发布日期:2004-11-24
  • 通讯作者: 冯增国
下载PDF ( 5411 ) 引用
导出

Preparation and Applications of Injectable Hydrogels

Wei Hongliang;Wang Liancai;Zhang Aiying;Zhu Kaiqiang;Feng Zengguo**   

  1. Department of Material Physics and Chemistry,?? School of Materials Science and Engineering, Beijing Institute of Technology
  • Received:2003-10-01 Revised:2004-01-01 Online:2004-11-24 Published:2004-11-24
  • Contact: Feng Zengguo
可注射水凝胶在再生医学和药物控释等方面有着广泛的用途,是近年来生物医用材料领域新的研究方向.本文综述了近年来人们在可注射水凝胶制备和应用方面的研究进展,最后展望了其发展前景.
关键词： 可注射水凝胶, 温敏水凝胶, 光聚合, 自组装, 生物相容性, 组织工程, 再生医学
Injectable hydrogels have been developed for biomedical applications, such as surgical reconstruction, controlled drug release and cell encapsulation. With respect to this new research direction in biomedical materials, recent progress in injectable hydrogels and their synthetic methodologies and applications are summarized. Finally, the development prospects of injectable hydrogels are also presented.
Key words: injectable hydrogels, thermo-reponsive hydrogel, photopolymerization, self-assembly, biocompatibi-lity, tissue engineering, regenerative medicine

中图分类号: 

()

[ 1 ] Osada Y , Gong J P. Advanced Materials , 1998 , 10 (11) :827 —837
[ 2 ] Wang L , Shelton R M, Cooper P R , et al . Biomaterials , 2003 ,24 : 3475 —3481
[ 3 ] Loebsack A , Greene K, Wyatt S , et al . Journal of Biomedical Materials Research ,2001 , 57 (4) : 575 —581
[ 4 ] Lee K Y, Alsberg E , Mooney D J . Journal of Biomedical Materials Research , 2001 , 56 (2) : 228 —233
[ 5 ] Bouhadir K H , Kruger G M, Lee K Y , et al . Journal of Pharmaceutical Sciences , 2000 , 89 (7) : 910 —919
[ 6 ] Westhaus E , Messersmith P B. Biomaterials , 2001 , 22 : 453 —462
[ 7 ] Behravesh E , Zygourakis K, Mikos A G. Journal of Biomedical Materials Research Part A , 2003 , 65A(2) : 261 —271
[ 8 ] Shin H , Jo S , Mikos A G. Journal of Biomedical Materials Research , 2002 , 61 (2) : 169 —179
[ 9 ] Payne R G, Yaszemski M J , Yasko A W , et al . Biomaterials ,2002 , 23 (22) : 4359 —4371
[10] Elbert D L , Pratt A B , Lutolf M P , Hubbell J A , et al . Journal of Controlled Release , 2001 , 76 : 11 —25
[11] Lutoff M P , Raeber G P , Zisch A H , Hubbell J A , et al . Adv.Mater. , 2003 , 15 : 888 —892
[12] Savas H , Guven O. Radiation Physics and Chemistry , 2002 , 64 :35 —40
[13] Ulanski P , Kadlubowski S , Rosiak J M. Radiation Physics and Chenistry , 2002 , 63 : 533 —537
[14] Yoshii F , Darwis D , Mitomo H , et al . Radiation Physics and Chenistry , 2000 , 57 : 417 —420
[15] Panda A , Manohar S B ,Sabhawarwal S , et al . Radiation Physics and Chenistry ,2000 , 58 : 101 —110
[16] Ulanski P , Kadlubowski S , Rosiak J M. Radiation Physics and Chemistry ,2002 , 63 : 533 —537
[17] Ulanski P , Janik I , Kadlubowski S , et al . Polym. Adv.Technol . , 2002 , 13 : 951 —959
[18] Rosiak J M, Janik I , Kadlubowski S , et al . Nuclear Instruments and Methods in Physics Research B , 2003 , 208 : 325 —330
[19] Nguyen K T, West J L. Biomaterial , 2002 , 23 : 4307 —4314
[20] Smeds K A , Grinstaff M W. Journal of Biomedical Materials Research , 2001 , 54 : 115 —121
[21] Muggli D S , Burkoth A K, Keyser S A , et al . Macromolecules ,1998 , 31 : 4120 —4125
[22] Burdick J A , Anseth K S. Biomaterials , 2002 , 23 : 4315 —4323
[23] Sawhney A S , Pathak C P , Hubbell J A. Macromolecules , 1993 ,26 : 581 —587
[24] West J L , Hubbell J A. Reactive Polymers , 1995 , 25 : 139 —147
[25] Cruise G M, Scharp D S , Hubbell J A. Biomaterials , 1998 , 19 :1287 —1294
[26] Tirelli N , Lutolf M P , Napoli A , Hubbell J A. Reviews in Molecular Biotechnology ,2002 , 90 : 3 —15
[27] Park Y D , Tirelli N , Hubbell J A. Biomaterials , 2003 , 24 :893 —900
[28] Elisseeff J , McIntosh W, Anseth K, et al . Journal of Biomedical Materials Research , 2000 , 51 : 164 —171
[29] Technology Review. February 2003 , 38 (www. Technologyreview.com)
[30] Jeong B , Kim S W, Bae Y H. Advanced Drug Delivery Reviews ,2002 , 54 : 37 —51
[31] Tate M C , Shear D A , Hoffman S W, et al . Biomaterials , 2001 ,22 : 1113 —1123
[32] Chenite A , Chaput C , Wang D , et al . Biomaterials 2000 , 21 :2155 —2161
[33] Molinaro G, Leroux J C , Damas J , et al . Biomaterials , 2002 ,23 : 2717 —2722
[34] Ruel-Gariepy E , Leclair G, Hildgen P , et al . Journal of Controlled Release , 2002 , 82 : 373 —383
[35] Jeong B , Bae Y H , Lee D S , et al . Nature , 1997 , 388 : 860 —862
[36] Jeong B , Bae Y H , Kim S W. Journal of Controlled Release ,2000 , 63 : 155 —163
[37] Jeong B , Bae Y H , Kim S W. J . Biomed. Mater. Res. , 2000 ,50 : 171 —177
[38] Jeong B , Kibbey M R , Bimbaum J C , et al . Macromolecules ,2000 , 33 : 8317 —8322
[39] Jeong B , Wang L Q , Gutowska A. Chem. Commun. , 2001 , 16 :1516 —1517
[40] Jeong B , Choi Y K, Bae Y H , et al . Journal of Controlled Release , 1999 , 62 : 109 —114
[41] Tachibana Y, Kurisawa M, Uyama H , et al . Chem. Commun. ,2003 , 106 —107
[42] Fujiwara T, Kimura Y. Macromol .Biosci . , 2002 , 2 : 11 —13
[43] Miyazaki T, Yamaoka K, et al . Macromol . Rapid Commun.2002 , 23 (8) : 447 —455
[44] Kopecek J . Nature , 2002 , 417 : 388 —391
[45] Nowak A P , Breedveld V , Pakstis L , Deming T J , et al . Nature ,2002 , 417 : 424 —428
[46] Abdou S , Collomb J , Sallas F , et al . Arch. Virol . , 1997 , 142 :1585 —1602
[47] Ooya T, Arizono K, Yui N. Polym. Adv. Technol . , 2000 , 11 :642 —651
[48] Wulff M, Alden M. European Journal of Pharmaceutical Sciences ,1999 , 8 : 269 —281
[49] Watanabe J , Ooya T, Nitta K H , et al . Biomaterials , 2002 , 23 :4041 —4048
[50] 赵三平(Zhao S P) , 冯增国(Feng Z G) , 朴东旭(Piao D X) .高等学校化学学报(Chemical Journal of Chinese Universities) ,2003 ,24 :186 —188
[51] Feng Z G,Zhao S P. Polymer , 2003 , 44 : 5177 —5186
[52] Ritter H , Sadowski O , Tepper E. Angew. Chem. Int . Ed. ,2003 , 42 : 3171 —3173
[53] Ikeda T, Watabe N , et al . Macromol . Chem. Phys. 2001 , 202 :1338 —1344
[54] Li J , Ni X P , Leong K W, Ooya T. Journal of Biomedical Materials Research Part A ,2003 , 65A(2) : 196 —202
[55] Salem A K, Rose F R A J , Oreffo R O C , et al . Adv. Mater. ,2003 , 15 (3) : 210 —213
[56] 姚康德(Yao K D) , 成国祥(Cheng G X) . 智能材料(Smart Materials) . 北京: 化学工业出版社, 2002. 66 —91
[57] Elisseeff J , Anseth K, Langer R , et al . Macromolecules , 1997 ,30 : 2182 —2184
[58] Hubbell J A. Current Opinion in Biotechnology , 1999 , 10 : 123 —129
[59] 杨志明(Yang ZM) . 组织工程(Tissue Engineering) . 北京: 化学工业出版社, 2002. 123
[1] 李良春, 郑仁林, 黄毅, 孙荣琴. 多组分自组装小分子水凝胶中的自分类组装[J]. 化学进展, 2023, 35(2): 274-286.
[2] 王萌, 宋贺, 李烨文. 三维自组装蓝相液晶光子晶体[J]. 化学进展, 2022, 34(8): 1734-1747.
[3] 韩冬雪, 金雪, 苗碗根, 焦体峰, 段鹏飞. 超分子组装体激发态手性的响应性[J]. 化学进展, 2022, 34(6): 1252-1262.
[4] 尹航, 李智, 郭晓峰, 冯岸超, 张立群, 汤华燊. RAFT链转移剂的选用原则及通用型RAFT链转移剂[J]. 化学进展, 2022, 34(6): 1298-1307.
[5] 刘玉玲, 胡腾达, 李伊莲, 林洋, Borsali Redouane, 廖英杰. 嵌段共聚物薄膜快速自组装方法[J]. 化学进展, 2022, 34(3): 609-615.
[6] 李红, 史晓丹, 李洁龄. 肽自组装水凝胶的制备及在生物医学中的应用[J]. 化学进展, 2022, 34(3): 568-579.
[7] 牛小连, 刘柯君, 廖子明, 徐慧伦, 陈维毅, 黄棣. 基于骨组织工程的静电纺纳米纤维[J]. 化学进展, 2022, 34(2): 342-355.
[8] 闫楚璇, 李青璘, 巩正奇, 陈颖芝, 王鲁宁. 纳米有机半导体光催化剂[J]. 化学进展, 2021, 33(11): 1917-1934.
[9] 冯业娜, 刘书河, 张书博, 薛彤, 庄鸿麟, 冯岸超. 基于聚合诱导自组装制备二氧化硅/聚合物纳米复合材料[J]. 化学进展, 2021, 33(11): 1953-1963.
[10] 王子瑄, 王跃飞, 齐崴, 苏荣欣, 何志敏. DNA-多肽复合分子的设计、组装与应用[J]. 化学进展, 2020, 32(6): 687-697.
[11] 智康康, 杨鑫. 天然产物凝胶及其凝胶质[J]. 化学进展, 2019, 31(9): 1314-1328.
[12] 梁敬时, 曾佳铭, 李俊杰, 佘珏芹, 谭瑞轩, 刘博. 阳离子抗菌聚合物[J]. 化学进展, 2019, 31(9): 1263-1282.
[13] 英启炜, 廖建国, 吴民行, 翟智皓, 刘欣茹. 球形生物活性玻璃作为运输载体的研究[J]. 化学进展, 2019, 31(5): 773-782.
[14] 林代武, 邢起国, 王跃飞, 齐崴, 苏荣欣, 何志敏. 多肽超分子手性自组装与应用[J]. 化学进展, 2019, 31(12): 1623-1636.
[15] 左新钢, 张昊岚, 周同, 高长有. 调控细胞迁移和组织再生的生物材料研究[J]. 化学进展, 2019, 31(11): 1576-1590.
阅读次数
全文


摘要

可注射水凝胶的制备与应用*