• 综述 •
朱泉霏, 郝俊迪, 严靖雯, 王雨, 冯钰锜. FAHFAs:生物功能、分析及合成[J]. 化学进展, 2021, 33(7): 1115-1125.
Quanfei Zhu, Jundi Hao, Jingwen Yan, Yu Wang, Yuqi Feng. FAHFAs: Biological Functions, Analysis and Synthesis[J]. Progress in Chemistry, 2021, 33(7): 1115-1125.
羟基脂肪酸支链脂肪酸酯(branched fatty acid esters of hydroxy fatty acids,FAHFAs)是一类新发现的生物活性脂质分子。FAHFAs在哺乳动物体内具有重要的生理功能,如改善葡萄糖耐量、增强胰岛素敏感性、维持血糖稳态和抗炎等。目前,FAHFA相关研究已成为脂质领域研究的一个新方向,受到科学家们的关注。本文总结了自FAHFAs发现至今的主要研究成果,从FAHFA的生理功能、代谢、生物体内的储存形式、分析检测和化学合成等五个方面进行介绍,以期为未来FAHFAs领域的研究提供一些借鉴。
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No. | FAHFA family | Structure a | Formula | No. | FAHFA family | Structure a | Formula |
---|---|---|---|---|---|---|---|
1 | POHPO | 16:1-O-16:1 | C32H58O4 | 39 | MAHAA | 14:0-O-20:0 | C34H66O4 |
2 | OAHPO | 18:1-O-16:1 | C34H62O4 | 40 | PAHAA | 16:0-O-20:0 | C36H70O4 |
3 | PAHPO | 16:0-O-16:1 | C32H60O4 | 41 | SAHAA | 18:0-O-20:0 | C38H74O4 |
4 | SAHPO | 18:0-O-16:1 | C34H64O4 | 42 | OAHAA | 18:1-O-20:0 | C38H72O4 |
5 | LAHPO | 18:2-O-16:1 | C34H60O4 | 43 | LAHAA | 18:2-O-20:0 | C38H70O4 |
6 | POHOA | 16:1-O-18:1 | C34H62O4 | 44 | AAHAA | 20:0-O-20:0 | C40H78O4 |
7 | OAHOA | 18:1-O-18:1 | C36H66O4 | 45 | PAHDDA | 16:0-O-12:0 | C28H54O4 |
8 | PAHOA | 16:0-O-18:1 | C34H64O4 | 46 | PDAHDA | 15:0-O-10:0 | C25H48O4 |
9 | SAHOA | 18:0-O-18:1 | C36H68O4 | 47 | PAHDA | 16:0-O-10:0 | C26H50O4 |
10 | ALAHOA | 18:3-O-18:1 | C36H62O4 | 48 | HDAHDA | 17:0-O-10:0 | C27H52O4 |
11 | LAHOA | 18:2-O-18:1 | C36H64O4 | 49 | SAHDA | 18:0-O-10:0 | C28H54O4 |
12 | POHPA | 16:1-O-16:0 | C32H60O4 | 50 | PDAHCA | 15:0-O-8:0 | C23H44O4 |
13 | OAHPA | 18:1-O-16:0 | C34H64O4 | 51 | PAHCA | 16:0-O-8:0 | C24H46O4 |
14 | PAHPA | 16:0-O-16:0 | C32H62O4 | 52 | HDAHCA | 17:0-O-8:0 | C25H48O4 |
15 | SAHPA | 18:0-O-16:0 | C34H66O4 | 53 | SAHCA | 18:0-O-8:0 | C26H50O4 |
16 | MAHPA | 14:0-O-16:0 | C30H58O4 | 54 | PDAHHA | 15:0-O-6:0 | C21H40O4 |
17 | MOHPA | 14:1-O-16:0 | C30H56O4 | 55 | PAHHA | 16:0-O-6:0 | C22H42O4 |
18 | PDAHPA | 15:0-O-16:0 | C31H60O4 | 56 | HDAHHA | 17:0-O-6:0 | C23H44O4 |
19 | HDAHPA | 17:0-O-16:0 | C33H64O4 | 57 | SAHHA | 18:0-O-6:0 | C24H46O4 |
20 | LAHPA | 18:2-O-16:0 | C34H62O4 | 58 | NAHHA | 19:0-O-6:0 | C25H48O4 |
21 | ALAHPA | 18:3-O-16:0 | C34H60O4 | 59 | AAHHA | 20:0-O-6:0 | C26H50O4 |
22 | AAHPA | 20:0-O-16:0 | C36H70O4 | 60 | MAHMA | 14:0-O-14:0 | C28H54O4 |
23 | POHSA | 16:1-O-18:0 | C34H64O4 | 61 | MOHMA | 14:1-O-14:0 | C28H52O4 |
24 | OAHSA | 18:1-O-18:0 | C36H68O4 | 62 | PDAHMA | 15:0-O-14:0 | C29H56O4 |
25 | PAHSA | 16:0-O-18:0 | C34H66O4 | 63 | PDEAHMA | 15:1-O-14:0 | C29H54O4 |
26 | SAHSA | 18:0-O-18:0 | C36H70O4 | 64 | PAHMA | 16:0-O-14:0 | C30H58O4 |
27 | MAHSA | 14:0-O-18:0 | C32H62O4 | 65 | POHMA | 16:1-O-14:0 | C30H56O4 |
28 | PDAHSA | 15:0-O-18:0 | C33H64O4 | 66 | SAHMA | 18:0-O-14:0 | C32H62O4 |
29 | HDAHSA | 17:0-O-18:0 | C35H68O4 | 67 | FAHFA(38:3) | 20:3-O-18:0 | C38H68O4 |
30 | LAHSA | 18:2-O-18:0 | C36H66O4 | 68 | FAHFA(38:5) | 20:4-O-18:1 | C38H64O4 |
31 | AAHSA | 20:0-O-18:0 | C38H74O4 | 69 | FAHFA(40:5) | 20:3-O-20:2 | C40H68O4 |
32 | ALAHSA | 18:3-O-18:0 | C36H64O4 | 70 | FAHFA(40:6) | 22:5-O-18:1 | C40H66O4 |
33 | DHAHLA | 22:6-O-18:2 | C40H62O4 | 71 | FAHFA(40:7) | 20:4-O-20:3 | C40H64O4 |
34 | POHLA | 16:1-O-18:2 | C34H60O4 | 72 | FAHFA(42:6) | 20:3-O-22:3 | C42H70O4 |
35 | PAHLA | 16:0-O-18:2 | C34H62O4 | 73 | FAHFA(42:8) | 20:4-O-22:4 | C42H66O4 |
36 | ALAHLA | 18:3-O-18:2 | C36H60O4 | 74 | FAHFA(42:9) | 20:4-O-22:5 | C42H64O4 |
37 | LAHLA | 18:2-O-18:2 | C36H62O4 | 75 | FAHFA(44:9) | 22:5-O-22:4 | C44H68O4 |
38 | DHAHDHA | 22:6-O-22:6 | C44H62O4 |
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