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化学进展 2018, Vol. 30 Issue (11): 1734-1748 DOI: 10.7536/PC170832 前一篇   后一篇

• 综述 •

脂质体类药物载体的微流控制备

何天稀1, 梁琼麟2*, 王九1, 罗国安2   

  1. 1. 陆军勤务学院油料系 重庆 401331;
    2. 清华大学化学系 北京 100084
  • 收稿日期:2017-08-28 修回日期:2018-05-05 出版日期:2018-11-15 发布日期:2018-08-17
  • 通讯作者: 梁琼麟,e-mail:liangql@tsinghua.edu.cn E-mail:liangql@tsinghua.edu.cn
  • 基金资助:
    科技部国际合作项目（No.2011DFA31860）、国家科技重大专项课题资助项目（No.2013ZX09507005）、国家自然科学基金项目（No.21175080）、重庆市应用基础与前沿研究项目（No.cstc2014jcyjA10056）和陆军勤务学院学术创新项目（No.YZ15-436）资助
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Microfluidic Fabrication of Liposomes as Drug Carriers

Tianxi He1, Qionglin Liang2*, Jiu Wang1, Guoan Luo2   

  1. 1. Department of Oil, Army Logistics University, Chongqing 401331, China;
    2. Department of Chemistry, Tsinghua University, Beijing 100084, China
  • Received:2017-08-28 Revised:2018-05-05 Online:2018-11-15 Published:2018-08-17
  • Supported by:
    The work was supported by the International Colaborative Program(No.2011DFA31860), the National Major Special Project of Science and Technology (No.2013ZX09507005), the National Natural Science Foundation of China (No.21175080), the Science and Technology Commission of Chongqing Municipality, China (No.cstc2014jcyjA10056), and the Academic Innovation Fund of Army Logistics University (No.YZ15-436).
脂质体在药物输送、人造细胞等许多领域有着巨大的应用前景。作为药物载体，脂质体可以保护药物、提高药效、减小药物对机体的毒性、使药物具有靶向性，因此发展或改进脂质体制备方法有着重要的意义。然而，传统的脂质体制备存在耗时长、设备贵、制备条件易变、前后处理步骤多、粒径不均一以及难重复等问题，基于此，脂质体的微流控制备技术逐渐发展起来。研究表明微流控技术在脂质体制备方面有着独特的优势，包括精确地控制脂质体的大小和尺寸分布。本文综述了近年来基于微流控技术的几种脂质体制备方法的研究进展，并对比了几种方法制备的脂质体的性质；进一步分析和探讨了当前微流控技术制备脂质体存在的问题，并展望了其发展趋势和方向。
关键词： 脂质体, 微流控, 药物载体, 制备
Liposomes are self-assembled phospholipid vesicles with great potential in drug delivery or fabricating artificial cells. As drugs carriers, liposome has many advantages, such as protecting drugs, improving efficacy, minimizing toxicity, reducing off-target effects, etc., thus liposome fabrication has arouse wide interests. However, there are several issues and concerns of conventional manufacturing techniques for their time-consuming processes, use of costly equipments, poor robustness of parameters, complex pre-and post-processing steps, polydispersity, and batch-to-batch inreproducibility. As a result, microfluidics-based techniques have been developed for liposome fabrication. It has been demonstrated that microfluidic techniques offer a range of advantages compared to conventional methods, especially the ability of precise control over the size and polydispersity of liposomes. This review focuses on recent development of microfluidic techniques with comparison of their outcomes of liposome fabrication. The bottlenecks of microfluidic techniques for liposome fabrication are discussed, and the future development for this field is also prospected.
Contents
1 Introduction
2 Microfluidic hydrodynamic focusing
3 Pulsed jetting
4 Droplet microfuluidics
4.1 Double emulsion templates
4.2 Droplet emulsion transfer
5 Other microfluidic methods
6 Conclusion and outlook
Key words: liposome, microfluidics, drug carriers, fabrication

中图分类号: 

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摘要

脂质体类药物载体的微流控制备