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化学进展 2018, Vol. 30 Issue (8): 1228-1241 DOI: 10.7536/PC180201 前一篇   后一篇

• 综述 •

多巴胺基纳米材料在生物医药中的应用

李红1,2, 赵媛媛1, 彭浩南3*   

  1. 1. 西安石油大学化学化工学院 陕西省油气田环境污染控制技术与储层保护重点实验室 西安 710065;
    2. 石油石化污染物控制与处理国家重点实验室 中国石油集团安全环保技术研究院 北京 102206;
    3. 陕西师范大学化学化工学院 应用表面与胶体化学教育部重点实验室 西安 710119
  • 收稿日期:2018-02-01 修回日期:2018-04-13 出版日期:2018-08-15 发布日期:2018-05-16
  • 通讯作者: 彭浩南 E-mail:phn@snnu.edu.cn
  • 基金资助:
    国家自然科学基金项目（No.21703169，21603138）、陕西省自然科学基础研究计划（No.2017JQ2024）和陕西省教育厅专项科研计划项目（No.17JK0600）资助
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Dopamine Based Nanomaterials for Biomedical Applications

Hong Li1,2, Yuanyuan Zhao1, Haonan Peng3*   

  1. 1. College of Chemistry and Chemical Engineering, Shaanxi Province Key Laboratory of Environmental Pollution Control and Reservoir Protection Technology of Oilfields, Xi'an Shiyou University, Xi'an 710065, China;
    2. State Key Laboratory of Petroleum Pollution Control, CNPC Research Institute of Safety and Environmental Technology, Beijing 102206, China;
    3. Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China
  • Received:2018-02-01 Revised:2018-04-13 Online:2018-08-15 Published:2018-05-16
  • Supported by:
    The work was supported by the National Natural Science Foundation of China(No. 21703169, 21603138), the Scientific Research Plan of Shaanxi Province of China(No. 2017JQ2024), and the Scientific Research Program Funded by Shaanxi Provincial Education Department(No. 17JK0600).
多巴胺是存在于人体内的一种儿茶酚胺类神经递质。自从研究者们发现了利用多巴胺的氧化自聚合反应制备聚多巴胺涂层的简便方法之后，多巴胺基纳米材料已经发展成为一类新兴的生物材料。多巴胺基纳米材料由于具有独特的物理化学性质，例如普适性的粘附性质、高化学反应活性、优良的生物相容性和生物降解性、以及光热转换性质，而在生物传感、药物输送、光热疗法、抗菌和组织工程等领域吸引了研究者们强烈的研究兴趣。本文综述了多巴胺基纳米材料的制备、功能化及在生物医药应用方面的最新进展。首先介绍了几种典型的多巴胺基纳米材料，并讨论影响其组装过程的因素。之后详细综述了这些材料在生物医药领域的应用，尤其是在癌症诊断和治疗方面。最后，本文提出了推进多巴胺基纳米材料临床应用需要发展的研究方向。
关键词： 多巴胺, 纳米材料, 生物医药, 光热疗法, 诊疗一体化
Dopamine is a catecholamine that acts as an important neurotransmitter in the nervous system. Since the introduction of the simple preparation method of polydopamine with the oxidative self-polymerization of dopamine, dopamine based nanomaterials have emerged as the novel biomaterials. They have attracted considerable interests in the fields of biosensing, drug delivery, photothermal therapy, antimicrobials, and tissue engineering due to their unique physicochemical properties, such as versatile adhesion property, high chemical reactivity, excellent biocompatibility and biodegradability, and strong photothermal conversion capacity. This review summarizes the recent advances on the fabrication, functionalization, and biomedical applications of dopamine based nanomaterials. Firstly, several typical dopamine based nanomaterials are introduced with a discussion of the factors that influence the assembly process. Then detailed elaboration is followed on their applications in biomedical fields, especially in cancer diagnosis and therapy. Finally, the review proposes some research topics for clinical applications of dopamine based nanomaterials.
Contents
1 Introduction
2 Dopamine based nanomaterials
2.1 Nanoparticles
2.2 Microcapsules
2.3 Polydopamine films
2.4 Other materials
3 Biomedical applications
3.1 Biosensing
3.2 Bioimaging
3.3 Drug delivery
3.4 Photothermal therapy
3.5 Theranostics
3.6 Antimicrobials
3.7 Tissue engineering
4 Conclusion and perspective
Key words: dopamine, nanomaterials, biomedicine, photothermal therapy, theranostics

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