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化学进展 2016, Vol. 28 Issue (8): 1196-1206 DOI: 10.7536/PC160212 前一篇   后一篇

• 综述与评论 •

聚天冬酰胺衍生物药物/基因载体的合成和应用

付开乔1*, 张光彦1*, 蒋序林2   

  1. 1. 湖北工业大学轻工学部 绿色轻工材料湖北省重点实验室 武汉 430068;
    2. 武汉大学化学与分子科学学院 生物医用高分子材料教育部重点实验室 武汉 430072
  • 收稿日期:2016-02-01 修回日期:2016-05-01 出版日期:2016-08-15 发布日期:2016-07-12
  • 通讯作者: 付开乔, 张光彦 E-mail:664094526@qq.com;zhangguangyan@whu.edu.cn
  • 基金资助:
    国家自然科学基金项目（No.21174109，21374083）和湖北工业大学博士科研启动基金项目（No.BSQD14003）资助
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Synthesis and Application of Polyaspartamide Derivatives for Drug/Gene Delivery

Fu Kaiqiao1*, Zhang Guangyan1*, Jiang Xulin2   

  1. 1. Hubei Provincial Key Laboratory of Green Materials for Light Industry, Department of Light Industry, Hubei University of Technology, Wuhan 430068, China;
    2. Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, China
  • Received:2016-02-01 Revised:2016-05-01 Online:2016-08-15 Published:2016-07-12
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No.21174109, 21374083) and the Doctoral Scientific Research Foundation of Hubei University of Technology (No. BSQD14003)
与碳链聚合物相比，聚氨基酸类高分子由于其生物相容性好、可降解代谢、毒副作用低等优点而被广泛应用于生物医药领域。基于天冬氨酸的聚天冬酰胺衍生物，其合成方法简单多样，通过对其修饰改性可制备出具有各种环境响应性（温度、pH和还原敏感）的智能高分子，得到高效、低毒的药物/基因载体，实现可控释放、增强疗效、降低药物副作用的目的。本文重点介绍了聚天冬酰胺衍生物（特别是刺激响应性聚天冬酰胺衍生物）的合成改性方法、及其在药物和基因载体领域最新的研究进展，并对其发展前景进行了展望。
关键词： 聚天冬酰胺, 药物载体, 基因载体, 刺激响应性
Compared with carbon-chain polymers, poly(amino acid)s have attracted much attentions in biomedical and pharmaceutical fields because of their good biocompatibility, biodegradability and nontoxicity. Polyaspartamide derivatives based on L-aspartic acid not only can be easily synthesized, but also can be further modified with various structures to prepare intelligent material with different stimuli-responsivity (such as temperature, pH and redox), resulting in controlled release, enhancement of therapeutic effects and reduction of the drug side effects. In this review, the different synthetic strategies for preparing polyaspartamide derivatives and the up-to-date developments on polyaspartamide derivatives for drug and gene delivery systems are summarized. Besides, the future perspectives of polyaspartamide derivatives are discussed.

Contents
1 Introduction
2 Synthesis of polyaspartamide derivatives
2.1 Aminolysis reaction of PSI
2.2 ROP of N-carboxyanhydride
3 Application of polyaspartamide derivatives
3.1 Drug delivery
3.2 Gene delivery
4 Outlook

Key words: polyaspartamide derivatives, drug delivery, gene delivery, stimuli-responsivity

中图分类号: 

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