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化学进展 2015, Vol. 27 Issue (4): 373-384 DOI: 10.7536/PC141020 前一篇   后一篇

• 综述与评价 •

基于多肽结构的聚合物水凝胶

王见伟, 宋利锋, 赵瑾*, 原续波   

  1. 天津大学材料科学与工程学院 天津市材料复合与功能化重点实验室 天津 300072
  • 收稿日期:2014-10-01 修回日期:2014-11-01 出版日期:2015-04-15 发布日期:2015-02-04
  • 通讯作者: 赵瑾 E-mail:zhaojin@tju.edu.cn
  • 基金资助:
    国家自然科学基金项目(No. 51103095)资助
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Polymer Hydrogels Based on Peptide Structure

Wang Jianwei, Song Lifeng, Zhao Jin*, Yuan Xubo   

  1. Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China
  • Received:2014-10-01 Revised:2014-11-01 Online:2015-04-15 Published:2015-02-04
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 51103095).
多肽由于具有良好的生物相容性和生物可降解性、生物活性以及自组装特性, 近年来受到了广泛的关注。将多肽自组装特性引入到聚合物中,可赋予聚合物形成凝胶性并对凝胶网络分子结构做出一定控制,进而使凝胶具有如环境响应、力学可调等结构控制性能;将特殊功能性多肽引入到化学交联的聚合物凝胶网络中,可赋予水凝胶生物功能性,如细胞黏附、酶降解、抗菌等;将多肽的凝胶网络构建、结构控制作用以及功能性同时引入获得的物理/化学双重交联凝胶不仅赋予水凝胶一定的功能性,且多肽自组装贡献的物理交联结构还能对化学交联凝胶网络起增强作用。本文综述了基于多肽自组装的物理交联聚合物水凝胶、多肽功能化的化学交联聚合物水凝胶以及基于多肽的物理/化学双重交联的聚合物水凝胶,并展望了这些水凝胶的发展前景。
关键词： 多肽, 水凝胶, 聚合物, 自组装, 功能性, 结构
Peptides with good biocompatibility and biodegradability, bioactivity and self-assembly ability have received widespread attention. Self-assembly properties of peptides can provide hydrogel formation ability to polymers, and then not only controlling gel network construction but endowing polymer hydrogels with stimuli-responsibility and mechanical modulation properties. By use of peptides with special functionality, chemical crosslinked polymer hydrogels are endowed with cell-adhesive, enzyme-sensitive and antibacterial biofunctionalities. In addition, introducing network construct and structural control properties as well as functionalities of peptide into physical/chemical double crosslinked hydrogels simultaneously can not only turn a hydrogel into functional materials but also enhance the chemical crosslinked network through peptide self-assembly. In this review, we summarize the current achievements in the study of peptide self-assembled polymer hydrogels, peptide-functionalized chemical crosslinked polymer hydrogels and physical/chemical double crosslinked polymer hydrogels based on peptide. Finally, development prospects of such hydrogels are briefly predicted.

Contents
1 Introduction
2 Physical cross-linked hydrogels
2.1 Hydrogels based on coiled coil assembly
2.2 Hydrogels based on β-sheet assembly
2.3 Hydrogels based on triple helix assembly
3 Chemical cross-linked hydrogels
3.1 Cell-adhesive
3.2 Enzyme-degradation
3.3 Antibacterial property
3.4 Tissue-adhesive
4 Physical/chemical double cross-linked hydrogels
5 Conclusion

Key words: peptide, hydrogel, polymer, self-assembly, functionality, structure

中图分类号: 

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摘要

基于多肽结构的聚合物水凝胶