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• 综述与评论 •

巯基-烯点击化学

徐源鸿1, 熊兴泉1*, 蔡雷1, 唐忠科1, 叶章基2,3   

  1. 1. 华侨大学材料科学与工程学院 福建省高校功能材料重点实验室, 厦门 361021;
    2. 中国船舶重工集团公司第七二五研究所厦门分部 厦门 361002;
    3. 海洋腐蚀与防护国防科技重点实验室 厦门 361002
  • 收稿日期:2011-06-01 修回日期:2011-08-01 出版日期:2012-03-24 发布日期:2011-11-25
  • 通讯作者: 熊兴泉 E-mail:xxqluli@hqu.edu.cn
  • 基金资助:

    国防重大安全基础研究(国防973)项目(No. 61310903)、国家自然科学基金项目(No. 21004024)、福建省“高校杰出青年科研人才培育计划”(No.11FJPY02)和福建省自然科学基金项目(No. 2011J01046 )资助

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Thiol-Ene Click Chemistry

Xu Yuanhong1, Xiong Xingquan1*, Cai Lei1, Tang Zhongke1, Ye Zhangji2,3   

  1. 1. The Key Laboratory for Functional Materials of Fujian Higher Education, College of Materials Science & Engineering, Huaqiao University, Xiamen 361021, China;
    2. Xiamen Branch of Luoyang Ship Material Research Institute, Xiamen 361002, China;
    3. State Key Laboratory for Marine Corrosion and Protection, Xiamen 361002, China
  • Received:2011-06-01 Revised:2011-08-01 Online:2012-03-24 Published:2011-11-25
点击化学自2001年由 Sharpless提出后,由于其高效、可靠、高选择性的特点迅速成为药物和高分子材料合成的新方法。随着对点击化学研究的深入,其反应类型在不断增多,应用范围也在不断扩大。自由基或亲核试剂引发的巯基-烯反应作为其中一种新型的点击反应具有点击化学的所有特性。本文从点击化学的概念、特征和类型出发,重点介绍了巯基-烯反应的机理和在合成功能聚合物、制备拓扑结构高分子、表面修饰以及生物药物等方面的应用,并对巯基-烯反应的最新研究成果进行综述,最后展望了巯基-烯的点击化学的发展前景。
关键词： 点击化学, 巯基-烯反应, 功能聚合物, 拓扑结构, 表面修饰, 生物分子
“Click chemistry”, introduced by Sharpless in 2001, becomes a new synthetic method used in areas such as drugs, polymers and materials rapidly because of its high efficiency, high selectivity and reliable characteristics. With the further research on click chemistry, the types of it are increasing continuously and the scope of application is also expanding. Radical-mediated or nucleophile-initiated thiol-ene reaction is a novel kind of click reactions, which shows the characteristics of click chemistry. Starting from the concept, characteristic and types of click chemistry, the mechanism and the wide applications of thiol-ene reaction in preparation of functional polymers and topologic macromolecules, polymeric materials surface modification and biomaterials are emphasized. Furthermore, the latest research based on thiol-ene chemistry is summarized. The prospects of thiol-ene reaction are also discussed. Contents
1 Introduction
2 Thiol-ene click reaction and mechanism
3 Applications of thiol-ene click chemistry
3.1 Synthesis of functional polymers
3.2 Synthesis of topologies polymers
3.3 Surface modification
3.4 Biological fields
3.5 Other fields
4 Conclusions and outlook
Key words: click chemistry, thiol-ene reaction, functional polymer, topologies, surface modification, biomolecules

中图分类号: 

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巯基-烯点击化学