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化学进展 2011, Vol. 23 Issue (01): 231-245 前一篇   后一篇

• 综述与评论 •

羟基磷灰石微球的制备、应用和功能化

倪淞波1, 李延报1, 王秀梅2   

  1. 1. 南京工业大学材料科学与工程学院材料化学工程国家重点实验室 南京 210009;
    2. 沈阳兴齐制药有限公司 沈阳 110024
  • 收稿日期:2010-06-01 修回日期:2010-08-01 出版日期:2011-01-20 发布日期:2011-09-02
  • 作者简介:e-mail: ybli@njut.edu.cn, lyanbao@163.com
  • 基金资助:

    国家自然科学基金项目(No.50802042)、江苏省自然科学基金项目(No.BK2008379)和材料化学工程国家重点实验室开放基金项目(KL09-6)和江苏省高等学校大学生实践创新训练计划项目资助

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Preparation,Application and Functionalization of Hydroxyapatite Microspheres

Ni Songbo1, Li Yanbao1, Wang Xiumei2   

  1. 1. State Key Laboratory of Materials-Oriented Chemical Engineering, College of Materials Science and Engineering, Nanjing University of Technology, Nanjing 210009, China;
    2. Shenyang Sinqi Phamaceutical Co., Ltd., Shengyang 110024, China
  • Received:2010-06-01 Revised:2010-08-01 Online:2011-01-20 Published:2011-09-02

羟基磷灰石(HA)是人体和动物骨骼的主要无机矿物成分。近年来,因HA具有特殊的表面特性和理化性能,良好的生物相容性、生物活性和骨传导作用,制备各种形态的HA材料成为从事生物、医学和材料的科研人员的研究重点。本文首先介绍了HA微球的制备方法,重点讨论了以聚合物为软模板以及用各种球形材料作为硬模板合成HA微球的制备方法,列出了不同方法制备HA微球的直径、孔径、比表面等各种性能参数。由于HA微球具有比表面积大、流动性好、质量轻、强度大,注射性能好,团聚能力低等HA块材不具有的特点,其在载体、骨修复材料、环境保护和色谱分离上有广泛的应用。针对HA微球在应用过程中遇到的问题,可采用表面改性或包覆、掺杂和将HA分散在其他基体中等措施对HA微球进行功能化修饰。HA 微球在控释载体、蛋白质分离以及细胞支架等方面具有极大的应用前景。

关键词： 羟基磷灰石, 微球, 载体, 功能化

Hydroxyapatite (HA) is a main mineral in vertebrate bone.During the latest years,HA has attracted attention from researchers in the areas of biology,medicine and materials,due to its special surface characteristics,physical and chemical properties,and excellent biocompatibility,bioactivity and osteoconductivity.In this review,the different methods used to prepare HA microspheres,including spray,template,microemulsion,emulsion technique and other methods are described in detail.The advantage and disadvantage of these methods are summarized.The pore sizes and surface areas of microspheres prepared in different ways are also listed.Subsequently,since HA microspheres possess high mobility,specific surface area and strength,low aggregation ability,injectability and light mass,they have been applied as carriers,scaffolds in tissue engineering,environmental protection,fillers and chromatography.Finally,three strategies are proposed to functionalize HA microspheres,which are surface treatment/modification,doping and dispersing HA in other matrix,respectively.HA microspheres have significantly potential to be applied as carriers,protein separation and cell scaffold in the future.

Key words: hydroxyapatite(HA), microsphere, carrier, functionalization

中图分类号: 

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