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有机小分子催化ε-己内酯开环聚合反应

许茸, 陈春霞*   

  1. 东北林业大学理学院化学化工系 哈尔滨 150040
  • 收稿日期:2011-11-01 修回日期:2012-01-01 出版日期:2012-08-24 发布日期:2012-08-06
  • 通讯作者: 陈春霞 E-mail:ccx1759@163.com
  • 基金资助:

    中央高校基本科研业务费专项资金项目(No.DL11CB06)和东北林业大学研究生创新资助项目(No.2010088)资助

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Ring-Opening Polymerization of ε-Caprolactone Catalyzed by Organocatalyst

Xu Rong, Chen Chunxia   

  1. College of Science, Northeast Forestry University, Harbin 150040, China
  • Received:2011-11-01 Revised:2012-01-01 Online:2012-08-24 Published:2012-08-06
聚己内酯(PCL)是一种生物可降解高分子材料,具有良好的环境、生物相容性,广泛应用于生物医学、包装等领域。有机小分子催化ε-己内酯单体开环聚合反应是制备聚己内酯的主要方式之一。与传统的金属催化相比,有机催化不仅反应条件温和、聚合可控,而且还可解决聚合物中金属残留问题,是目前高分子合成化学的研究热点。本文按照催化体系的不同活化方式,讨论了近年来有机催化在ε-己内酯开环聚合反应中的研究进展,归纳总结了不同催化体系的优缺点,并在此基础上展望了有机小分子催化剂在ε-己内酯开环聚合反应中的发展趋势和应用前景。
关键词： 有机催化, 开环聚合, 聚&epsilon, -己内酯
Poly(ε-caprolactone) (PCL) is an important class of biocompatible materials, which makes them interesting materials for a range of biomedical and commodity applications, including controlled drug release, tissue engineering, medical implants or environmentally friendly packaging materials. PCL can be prepared through the ring-opening polymerization of ε-caprolactone catalyzed by organic molecules. Compared to traditional metal-catalyzed ROPs, organocatalysis processes can be performed under milder reaction conditions with controlled molar masses and narrow dispersities, furthermore the metal contaminants of the polymer products can be avoided to be removed prior to application as biomedical and pharmaceutical materials. Herein the progress of organocatalysts in the ring-opening polymerization of ε-caprolactone is reviewed according to different means of the activation of the catalysts. The advantages and disadvantages of various catalytic systems are summarized, and development trends and application prospects of organocatalysis for polymerization of ε-caprolactone are also discussed. Contents 1 Introduction
2 Organocatalysts based on electrophilic monomer activation
3 Lewis bases and organocatalysts based on nucleophilic monomer activation
3.1 Organocatalysis by nucleophilic monomer activation
3.2 Organocatalysis by initiator/chain-end activation
4 Synergistic bifunctional organocatalysts and initiator/chain-end activation
5 Conclusion
Key words: organocatalysis, ring-opening polymerization(ROP), &epsilon, -caprolactone

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