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化学进展 2012, Vol. 24 Issue (07): 1270-1276 前一篇   后一篇

• 综述与评论 •

磁性有序介孔炭的合成及新应用

田勇, 王加, 钟国英, 林汉森, 王秀芳*   

  1. 广东药学院药科学院 广州 510006
  • 收稿日期:2011-10-01 修回日期:2011-11-01 出版日期:2012-07-24 发布日期:2012-06-30
  • 通讯作者: 王秀芳 E-mail:x_f_wang@163.com
  • 基金资助:

    国家自然科学基金项目(No.50802017)和广东省高等学校高层次人才项目(人才引进专项基金,2011年度)资助

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Synthesis and New Application of Magnetic Ordered Mesoporous Carbons

Tian Yong, Wang Jia, Zhong Guoying, Lin Hansen, Wang Xiufang   

  1. College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
  • Received:2011-10-01 Revised:2011-11-01 Online:2012-07-24 Published:2012-06-30
有序介孔炭作为一类崭新的功能材料,因具有高比表面积、孔径分布集中、孔径结构可调、大孔容、高度热稳定性和机械稳定性等优异特性而备受瞩目,广泛应用于水体净化、催化及光、电、磁等领域。其极佳的生物相容性使其在药物负载领域有巨大的潜在应用价值。根据磁性有序介孔炭材料的最新研究动态和应用研究热点,本文综述了磁性有序介孔炭合成作用机理、药物负载效率和介孔结构(如比表面、孔容、孔径分布)制约因素。讨论分析了各种合成方法的优劣和孔结构参数制约载药量的研究瓶颈。并着重对磁性有序介孔炭在医药领域的新应用进行了阐述和评价。旨在为探讨磁性有序介孔炭在优化合成工艺技术参数、提高药物负载量和靶向释药应用趋势方面提供理论导向。
关键词： 磁性有序介孔炭, 合成机理, 新应用, 药物负载
Ordered mesoporous carbons (OMCs) have attracted great technological interest for the applications of adsorption and purification of water, electronic, catalytic, magnetic systems due to their remarkable properties such as high specific surface area, narrow pore size distribution, tunable pore structure, large pore volume and high thermal and mechanical stability. Moreover, the excellent biocompatibility of OMCs make them highly prospective and valuable in drug delivery systems. The synthesis mechanisms, drug loading efficiency and structural restraint factors such as specific surface area, pore volume, pore size distribution are summarized according to the recent reports and developments on magnetic OMCs. The advantages, disadvantages of various synthesis methods, essence of problem, the restrictive factors between porous structural parameters and drug loading degree are discussed and analyzed. The new applications of magnetic OMCs in drug delivery systems are emphasized and evaluated. It is aimed to provide theoretical guidance for the further research of magnetic OMCs on the optimization of synthesis parameters, improvement of drug loading degree and targeted drug release application tendency. Contents
1 Introduction
2 Synthesis mechanisms and puzzles for magnetic ordered mesoporous carbon
2.1 Vapor infiltration method
2.2 Wet impregnation technique
2.3 Evaporation induced self-assembly
3 Comparisons for various synthesis methods and analysis of structural influencing factors
3.1 Hard templating method
3.2 Soft templating method
4 Application fields and development tendency
4.1 Application in bio-separation and bio-catalysis fields
4.2 Application in adsorption field
4.3 New application in medicinal and pharmaceutical fields
5 Summary and prospect
Key words: magnetic ordered mesoporous carbon, synthesis mechanism, new application, drug loading

中图分类号: 

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摘要

磁性有序介孔炭的合成及新应用