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化学进展 2012, Vol. 24 Issue (04): 637-649 前一篇   后一篇

• 综述与评论 •

中药炮制过程化学机理研究

蔡宝昌1,2,3, 秦昆明1,2, 吴皓1,3, 蔡皓1,3, 陆兔林1,3, 张兴德1,3   

  1. 1. 南京中医药大学国家教育部中药炮制规范化及标准化工程研究中心 南京 210029;
    2. 南京海昌中药集团有限公司 南京 210061;
    3. 国家中医药管理局中药炮制标准重点研究室 南京 210046
  • 收稿日期:2011-08-01 修回日期:2011-11-01 出版日期:2012-04-24 发布日期:2012-02-08
  • 基金资助:

    江苏省自然科学基金项目(No.BK2011135);国家自然科学基金项目(No.3087438,30973939,81001640,30940093)资助

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Chemical Mechanism During Chinese Medicine Processing

Cai Baochang1,2,3, Qin Kunming1,2, Wu Hao1,3, Cai Hao1,3, Lu Tulin1,3, Zhang Xingde1,3   

  1. 1. Engineering Center of State Ministry of Education for Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210029, China;
    2. Nanjing Haichang Chinese Medicine Group Co., Ltd, Nanjing 210061, China;
    3. Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing, Nanjing 210046, China
  • Received:2011-08-01 Revised:2011-11-01 Online:2012-04-24 Published:2012-02-08
中药炮制是中国的一项传统制药技术,也是中药区别于天然药物的显著特点。中药材经过加工炮制以后发生了复杂的化学变化,随着这些化学变化而改变的物质基础是中药炮制前后性味、功能改变的重要原因。阐明中药炮制过程中发生的这些化学变化是中药炮制机理研究的主要内容。近年来,国内外很多研究机构对中药炮制过程的化学机理进行了深入研究,初步阐明了多味中药炮制过程中发生的化学反应及化学成分变化,主要的化学反应包括水解反应、氧化反应、置换反应、异构化反应和分解反应等。本文对近年来中药炮制过程中化学反应机理领域取得的研究成果进行了综述,并对中药炮制过程化学机理研究的方向及前景进行了探讨。
关键词： 中药炮制, 反应, 化学成分, 化学机理
Chinese medicine processing is a traditional Chinese pharmaceutical technology, and it is also the main characteristic property that distinguish traditional Chinese medicine and natural medicine. There are complex chemical changes during the process of Chinese medicine processing, and these chemical constituents which changed during processing maybe the basis of clinical efficacy changes. To clarify the changes of the chemical constituents and the chemical reactions in Chinese medicine during the processing process is the main purpose of the chemical mechanism research of Chinese medicine processing. In recent years, many research institutions at home and abroad have done deeply research in chemical mechanism during the process of Chinese medicine processing. The chemaical reactions and chemical mechanisms ocurred in some traditional Chinese medicines during the process of Chinese medicine processing were initially clarified. The main chemical reactions occurred in the Chinese medicine processing are hydrolysis reaction, oxidation reaction, replacement reaction, isomerization reaction, decomposition reaction,etc. The main achievements in the chemical mechanism research during the process of Chinese medicine processing are reviewed. The research directions and future in the chemical mechanism research of Chinese medicine processing are prospected.
Contents
1 Introduction
2 Chemical composition change and its mechanism during Chinese medicine processing
2.1 Hydrolysis reaction
2.2 Isomerization reaction
2.3 Oxidation reaction
2.4 Replacement reaction
2.5 Decomposition reaction
2.6 Condensation reaction
2.7 Others
3 Problems and countermeasures
3.1 Application of modern analytical techniques to explore the Chinese medicine processing mechanism
3.2 Combinational research of chemical analysis and pharmaceutical efficacy mechanism during Chinese medicine processing
3.3 Exploration and establishment of new methods to clarify the mechanisms of Chinese medicine processing
4 Conclusion
Key words: Chinese medicine processing, reaction, chemical constituents, chemical mechanism

中图分类号: 

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摘要

中药炮制过程化学机理研究