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PDF(1177 KB)
PDF(1177 KB)
纳米毒理学研究中的放射分析方法
- 张智勇*, 赵宇亮, 柴之芳
作者信息
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Radioanalytical Methods in Nanotoxicology Studies
- Zhang Zhiyong*, Zhao Yuliang, Chai Zhifang
Author information
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文章历史
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摘要
随着纳米技术及其应用的迅速发展,纳米材料对生命体和生态环境的影响引起了社会公众、纳米产品生产厂家、科研工作者和各国政府的密切关注。纳米毒理学已成为纳米技术和毒理学的重要分支。纳米毒理学研究依赖于多种分析方法,用于纳米材料物理化学特性的表征及检测生命体中的纳米材料。放射分析方法由于其高灵敏度、高准确度、原位和体内分析能力,在纳米毒理学研究中能够发挥重要作用。本文综述了放射分析方法在纳米毒理学研究中应用的最新进展,重点介绍了针对不同纳米材料的放射性标记技术。
Abstract
With the rapid development of nanotechnology and its applications, the potential interactions of nanomaterials with living systems and the environment have attracted increasing attention from the public, as well as from manufacturers of nanomaterial-based products, academic researchers and policymakers. Nanotoxicology is emerging as an important subdiscipline of nanotechnology as well as toxicology. Nanotoxicology studies rely on many analytical methods for the characterization of nanomaterials and detection of nanomaterials in living systems. In this case, radioanalytical methods can play an important role due to their intrinsic merits such as high sensitivity, good accuracy, ability to distinguish the endogenous or exogenous sources of materials, and ability of in situ and in vivo analysis. This article reviews recent progress of applications of radioanalytical methods in nanotoxicology studies, and the emphasis is radiolabeling methods of nanomaterials.
Contents
1 Introduction
2 Chemical impurity analysis of carbon nanotubes using neutron activation analysis
3 Radiolabelling of nanomaterials for in vivo radiotracer studies
3.1 Radiolabeling of carbon nanomaterials
3.2 Radiolabeling of metallic and metal oxide nanomaterials
3.3 Radiolabeling of nanomedicines and other nanoparticles
4 Conclusions and outlook
关键词
放射分析 / 纳米毒理学 / 纳米材料 {{custom_keyword}} /
Key words
radioanalytical methods / nanotoxicology / nanomaterials {{custom_keyword}} /
中图分类号：
O657.4
TB383
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脚注
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基金
国家重点基础研究发展计划(973)项目(2011CB933400)和国家自然科学基金项目(No.10875136,10905062,11005118) 资助
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