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化学进展 2011, Vol. 23 Issue (7): 1527-1533 前一篇   后一篇

• 放射化学专辑 •

纳米毒理学研究中的放射分析方法

张智勇*, 赵宇亮, 柴之芳   

  1. 中国科学院高能物理研究所核分析技术重点实验室 纳米生物效应与安全性重点实验室 北京 100049
  • 收稿日期:2010-12-01 修回日期:2011-03-01 出版日期:2011-07-24 发布日期:2012-03-15
  • 通讯作者: e-mail: zhangzhy@ihep.ac.cn E-mail:zhangzhy@ihep.ac.cn
  • 基金资助:

    国家重点基础研究发展计划(973)项目(2011CB933400)和国家自然科学基金项目(No.10875136,10905062,11005118) 资助

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Radioanalytical Methods in Nanotoxicology Studies

Zhang Zhiyong*, Zhao Yuliang, Chai Zhifang   

  1. Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, The Chinese Academy of Sciences, Beijing 100049, China
  • Received:2010-12-01 Revised:2011-03-01 Online:2011-07-24 Published:2012-03-15

随着纳米技术及其应用的迅速发展,纳米材料对生命体和生态环境的影响引起了社会公众、纳米产品生产厂家、科研工作者和各国政府的密切关注。纳米毒理学已成为纳米技术和毒理学的重要分支。纳米毒理学研究依赖于多种分析方法,用于纳米材料物理化学特性的表征及检测生命体中的纳米材料。放射分析方法由于其高灵敏度、高准确度、原位和体内分析能力,在纳米毒理学研究中能够发挥重要作用。本文综述了放射分析方法在纳米毒理学研究中应用的最新进展,重点介绍了针对不同纳米材料的放射性标记技术。

关键词： 放射分析, 纳米毒理学, 纳米材料

With the rapid development of nanotechnology and its applications, the potential interactions of nanomaterials with living systems and the environment have attracted increasing attention from the public, as well as from manufacturers of nanomaterial-based products, academic researchers and policymakers. Nanotoxicology is emerging as an important subdiscipline of nanotechnology as well as toxicology. Nanotoxicology studies rely on many analytical methods for the characterization of nanomaterials and detection of nanomaterials in living systems. In this case, radioanalytical methods can play an important role due to their intrinsic merits such as high sensitivity, good accuracy, ability to distinguish the endogenous or exogenous sources of materials, and ability of in situ and in vivo analysis. This article reviews recent progress of applications of radioanalytical methods in nanotoxicology studies, and the emphasis is radiolabeling methods of nanomaterials.

Contents
1 Introduction
2 Chemical impurity analysis of carbon nanotubes using neutron activation analysis
3 Radiolabelling of nanomaterials for in vivo radiotracer studies
3.1 Radiolabeling of carbon nanomaterials
3.2 Radiolabeling of metallic and metal oxide nanomaterials
3.3 Radiolabeling of nanomedicines and other nanoparticles
4 Conclusions and outlook

Key words: radioanalytical methods, nanotoxicology, nanomaterials

中图分类号: 

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