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化学进展 2011, Vol. 23 Issue (7): 1493-1500 前一篇   后一篇

• 放射化学专辑 •

99mTc放射性药物化学

梅雷, 褚泰伟*   

  1. 北京大学化学与分子工程学院 放射化学与辐射化学重点学科实验室 北京分子科学国家实验室 北京 100871
  • 收稿日期:2010-12-01 修回日期:2011-03-01 出版日期:2011-07-24 发布日期:2012-03-15
  • 通讯作者: e-mail: twchu@pku.edu.cn E-mail:twchu@pku.edu.cn
  • 基金资助:

    国家自然科学基金项目(No.20771011,2107101)资助

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Technetium-99m Radiopharmaceutical Chemistry

Mei Lei, Chu Taiwei*   

  1. Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
  • Received:2010-12-01 Revised:2011-03-01 Online:2011-07-24 Published:2012-03-15

99mTc放射性药物在科学研究和临床上已经得到了广泛的应用,但如何发展药效更好的药物以适应临床诊断的需求,依然是亟待解决的问题。新药物配体和金属核的引入以及新的标记方法的发展是目前99mTc的放射性药物的热点。本文介绍99mTc放射性药物化学的几种新标记方法,包括羰基锝标记的新型配体和新方法、99mTc高价配合物的制备和应用等,旨在对有关研究者提供参考。

关键词： 放射性药物化学, 标记, 羰基锝, 高价锝

Technetium based radiopharmaceuticals have been widely used in scientific research and clinic. A large amount of new radiopharmaceuticals have been exploited and used. However, how to develop pharmaceuticals with better treatments and wider applicability to meet the need of clinic is still an urgent problem. The introduction of new ligands and cores and development of new strategies of labeling have become a hot subject in the technetium based radiopharmaceutical field. In order to provide some references to the researchers,introduction of some new labeling methods used for technetium-99m-labeled radiopharmaceuticals, including new ligands and methods for 99mTc-tricarbonyl technetium labeling, preparation and application of the high-valent technetium, are carried out in this paper.

Contents
1 Introduction
2 Recent progress of labeling with tricarbonyl technetium
2.1 New ligands for labeling of tricarbonyl technetium
2.2 New strategy for labeling of tricarbonyl technetium
3 Complex of high-valent technetium
4 Conclusion and outlook

Key words: radiopharmaceutical chemistry, labeling, tricarbonyl technetium, high-valent technetium

中图分类号: 

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摘要

99mTc放射性药物化学