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化学进展 2011, Vol. 23 Issue (5): 930-940 前一篇   后一篇

• 综述与评论 •

两亲嵌段共聚物胶束用作医用材料

何文1, 丁元菊1, 鲁在君1, 杨其峰2   

  1. 1. 山东大学化学与化工学院 特种功能聚集体材料教育部重点实验室 济南 250100;
    2. 山东大学齐鲁医院乳腺外科 济南 250012
  • 收稿日期:2010-08-01 修回日期:2010-11-01 出版日期:2011-05-24 发布日期:2011-05-04
  • 基金资助:

    山东省自然科学基金项目(No.Y2008B04)和国家自然科学基金项目(No.21074067,81072150)资助

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Amphiphilic Block Copolymer Micelles for Medical Materials

He Wen1, Ding Yuanju1, Lu Zaijun1, Yang Qifeng2   

  1. 1. Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China;
    2. Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan 250012, China
  • Received:2010-08-01 Revised:2010-11-01 Online:2011-05-24 Published:2011-05-04

两亲嵌段共聚物可以在水溶液中自组装形成亲水性链段为外壳、疏水性链段为内核的胶束,这种胶束能够用作药物载体而引起人们极大的关注。本文综述了两亲嵌段共聚物胶束用作医用材料的研究进展,主要内容包括医用两亲嵌段共聚物的种类,胶束化,以及用作诊断试剂载体、药物缓释载体、靶向载体等。两亲嵌段共聚物胶束用作磁共振造影剂载体有利于肿瘤的诊断,用作药物缓释载体可以有效增溶难溶性抗肿瘤药物,延长药物在体内的血液循环时间。此外,通过对胶束表面进行修饰或者施加外场,还可以实现靶向功能。因此,两亲嵌段共聚物胶束在医用材料领域有着广阔的发展前景。

关键词： 两亲嵌段共聚物, 胶束, 诊断, 药物缓释, 靶向

Amphiphilic block copolymers can self assemble into micelles containing the outer shell of hydrophilic blocks and inner core of hydrophobic blocks in aqueous solution. These micelles can be used for drug carriers and have attracted much attention. In this article, we review the research progress in amphiphilic block copolymer micelles for medical materials, including species of medical amphiphilic block copolymers, micellization, and carriers of diagnostics, drug release and targeting. Amphiphilic block copolymer micelles as MRI contrast agent carriers are beneficial to tumor diagnosis. These micelles as drug carriers can enhance the solubility of hydrophobic anticancer drugs and extend drug circulation time in vivo. In addition, amphiphilic block copolymer micelles are capable of achieving the target function through either attachment of targeting ligands to the micelle surface or introduction of external fields. Therefore, the amphiphilic block copolymer micelles have broad development prospects in the field of medical materials.

Key words: amphiphilic block copolymers, micelles, diagnostics, drug release, targeting

中图分类号: 

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