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化学进展 2011, Vol. 23 Issue (5): 914-922 前一篇   后一篇

• 综述与评论 •

生物医用类环糊精/聚合物(准)聚轮烷

董海青1, 李永勇1, 李兰1, 时东陆1,2   

  1. 1. 同济大学先进材料与纳米生物医学研究院 上海 20009;
    2. 美国辛辛那提大学化学与材料工程学院 辛辛那提 45229
  • 收稿日期:2010-08-01 修回日期:2010-11-01 出版日期:2011-05-24 发布日期:2011-05-04
  • 基金资助:

    中国博士后基金项目(No.20100470111)、上海市自然科学基金项目(No.10ZR1432100)和上海博士后基金项目(No.10R21415700)资助

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导出 被引次数 ( 9 | 1 )

Cyclodextrins/Polymer Based (Pseudo)Polyrotaxanes for Biomedical Applications

Dong Haiqing1, Li Yongyong1, Li Lan1, Shi Donglu1,2   

  1. 1. The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai 20009;
    2. Department of Chemical and Materials Engineering, University of Cincinnati, Cincinnati, Ohio 45229, USA
  • Received:2010-08-01 Revised:2010-11-01 Online:2011-05-24 Published:2011-05-04

环糊精及其衍生物具有“内疏水、外亲水”的特殊分子结构,可与许多客体分子包结形成包合物。利用环糊精与聚合物的包结作用构建稳定、结构可控并具有广泛应用前景的生物医用材料是材料及医学界研究的焦点之一。本文介绍了环糊精基(准)聚轮烷的概念及其组装驱动力,同时围绕由环糊精和聚合物组装形成的(准)聚轮烷在生物医用方面的研究包括药物载体(如超分子凝胶、超分子胶束、超分子纳米囊泡、药物键合(准)聚轮烷、刺激响应型(准)聚轮烷等)、基因载体、多重识别与靶向、形状记忆材料及其它相关领域工作进展作一概述。

关键词： 环糊精, (准)聚轮烷, 生物医用, 自组装

Cyclodextrin(CD) and its derivatives have the special molecular structures with hydrophobic cavities and hydrophilic surfaces, which can form inclusion complexes with many guest molecules. Construction of biomaterials with stability, structural controllability as well as potential applications by supramolecular self-assembly is one of the research focuses in materials and medical fields. This paper introduces the concept of CDs based (pseudo) polyrotaxanes and the driving forces for their self-assembly, mainly reviews the biomedical applications of (pseudo) polyrotaxanes self-assembled from CDs and polymers, including drug carriers (such as supramolecular hydrogels, supramolecular micelles, supramolecular nanocapsules, drug conjugated (pseudo) polyrotaxane and stimuli-responsive (pseudo) polyrotaxane), gene carriers, multifold recognition and targeting, as well as other applications involving shape memory materials, anticoagulant materials, DNA-cleavage reagent and trypsin inhibitor.

Key words: cyclodextrins, (pseudo)polyrotaxane, biomedical application, self-assembly

中图分类号: 

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[1] Harada A, Hashidzume A, Takashima Y. Adv. Polym. Sci., 2006, 201: 1-43
[2] Rekharsky M V, Inoue Y. Chem. Rev., 1998, 98: 1875-1917
[3] Uekama K, Hirayama F, Irie T. Chem. Rev., 1998, 98: 2045-2076
[4] Shimpi S, Chauhan B, Shimpi P. Acta Pharm., 2005, 55: 139-156
[5] Varca G H C, Andreo N, Lopes P S, Ferraz H G. Curr. Protein Pep. Sci., 2010, 11: 255-263
[6] Harada A. Accounts Chem. Res., 2001, 34: 456-464
[7] Nakashima N, Kawabuchi A, Murakami H. J. Incl. Phenom. Molecular Recogn. Chem., 1998, 32: 363-373
[8] Brunsveld L, Folmer B J B, Meijer E W, Sijbesma R P. Chem. Rev., 2001, 101: 4071-4097
[9] Jun Y J, Park K M, Joung Y K, Park K D, Lee S J. Macromol. Res., 2008, 16: 704-710
[10] Krishna O D, Kiick K L. Biopolymers, 2010, 94: 32-48
[11] Ito F, Usui K, Kawahara D, Suenaga A, Maki T, Kidoaki S, Suzuki H, Taiji M, Itoh M, Hayashizaki Y, Matsuda T. Biomaterials, 2010, 31: 58-66
[12] Censi R, Vermonden T, van Steenbergen M J, deschout H, Braeckmans K, de Smedt S C, van Nostrum C F, di Martino P, Hennink W E. J. Control. Release, 2009, 140: 230-236
[13] Chen G H, Hoffman A S. Nature, 1995, 373: 49-52
[14] Li J. Adv. Polym. Sci., 2009, 222: 79-112
[15] Li J, Loh X J. Adv. Drug Deliv. Rev., 2008, 60: 1000-1017
[16] 赵三平(Zhao S P), 徐卫林(Xu W L). 化学进展(Prog. Chem.), 2010, 22: 916-926
[17] Liao X J, Chen G S, Liu X X, Chen W X, Chen F E, Jiang M. Angew. Chem. Int. Edit., 2010, 49: 4409-4413
[18] Chen Y, Pang X H, Dong C M. Adv. Funct. Mater., 2010, 20: 579-586
[19] Zhao S P, Xu W L. J. Polym. Res., 2010, 17: 503-510
[20] Park C, Lee K, Kim C. Angew. Chem. Int. Ed., 2009, 48: 1275-1278
[21] Wang Z M, Chen Y M. Macromolecules, 2007, 40: 3402-3407
[22] Hui Z Y, Zhang X L, Yu J H, Huang J, Liang Z S, Wang D X, Huang H T, Xu P H. J. Appl. Polym. Sci., 2010, 116: 1894-1901
[23] Ogoshi T, Takashima Y, Yamaguchi H, Harada A. J. Am. Chem. Soc., 2007, 129: 4878-4879
[24] Ma D, Zhang L M. J. Phys. Chem. B, 2008, 112: 6315-6321
[25] Sharma P, Garg S. Adv. Drug Deliv. Rev., 2010, 62: 491-502
[26] Carlsen A, Lecommandoux S. Curr. Opin. Colloid Inter., 2009, 14: 329-339
[27] Dong H Q, Li Y Y, Cai S J, Zhuo R X, Zhang X Z, Liu L J. Angew. Chem. In. Ed., 2008, 47: 5573-5576
[28] Huang J, Ren L X, Chen Y M. Polym. Int., 2008, 57: 714-721
[29] Zhang X W, Zhu X Q, Ke F Y, Ye L, Chen E Q, Zhang A Y, Feng Z G. Polymer, 2009, 50: 4343-4351
[30] Yang C, Li J. J. Phys. Chem. B, 2009, 113: 682-690
[31] Zhang X W, Ke F Y, Han J, Ye L, Chen E Q, Zhang A Y, Feng Z G. Soft Matter, 2009, 5: 4797-4803
[32] Wu Y L, Li J. Angew. Chem. Int. Ed., 2009, 48: 3842-3845
[33] Qin J, Meng X W, Li B J, Ha W, Yu X Q, Zhang S. J. Colloid Int. Sci., 2010, 350: 447-452
[34] Nagahama K, Ohaura J, Sakaue H, Ouchi T, Ohya Y, Yui N. Chem. Lett., 2010, 39: 250-251
[35] Liu J H, Sondjaja H R, Tam K C. Langmiur, 2007, 23: 5106-5109
[36] Ooya T, Mori H, Terano M, Yui N. Macromol. Rapid Commun., 1995, 16: 259-263
[37] Watanabe J, Ooya T, Yui N. J. Biomat. Sci. Polym. E, 1999, 10: 1275-1288
[38] Moon C, Kwon Y M, Lee W K, Park Y J, Chang L C, Yang V C. J. Biomed. Mater. Res. A, 2008, 84A: 238-246
[39] Moon C, Kwon Y M, Lee W K, Park Y J, Yang V C. J. Control. Release, 2007, 124: 43-50
[40] Ooya T, Arizono K, Yui N. Polym. Adv. Technol., 2000, 11: 642-651
[41] Ichi T, Watanabe J, Ooya T, Yui N. Biomacromolecules, 2001, 2: 204-210
[42] Martin G R, Jain R K. Cancer Res., 1994, 54: 5670-5674
[43] Bae Y, Fukushima S, Harada A, Kataoka K. Angew. Chem. Int. Ed., 2003, 42: 4640-4643
[44] Li Y Y, Dong H Q, Wang K, Shi D L, Zhang X Z, Zhuo R X. Sci. China Ser. B, 2010, 53: 447-457
[45] Roy D, Cambre J N, Sumerlin B S. Prog. Polym. Sci., 2010, 35: 278-301
[46] Yuan F, Tam K C. Soft Matter, 2010, 6: 4613-4630
[47] Wang J, Gao P, Ye L, Zhang A Y, Feng Z G. J. Phys. Chem. B, 2010, 114: 5342-5349
[48] Smith D K. J. Chem. Educ., 2005, 82: 393-400
[49] Ooya T, Choi H S, Yamashita A, Yui N, Sugaya Y, Kano A, Maruyama A, Akita H, Ito R, Kogure K, Harashima H. J. Am. Chem. Soc., 2006, 128: 3852-3853
[50] Li J, Yang C, Li H Z, Wang X, Goh S H, Ding J L, Wang D Y, Leong K W. Adv. Mater., 2006, 18: 2969-2974
[51] Yang C, Wang X, Li H Z, Tan E, Lim C T, Li J. J. Phys. Chem. B, 2009, 113: 7903-7911
[52] Shuai X T, Merdan T, Unger F, Kissel T. Bioconjugate Chem., 2005, 16: 322-329
[53] Yamashita A, Yui N, Ooya T, Kano A, Maruyama A, Akita H, Kogure K, Harashima H. Nat. Protoc., 2006, 1: 2861-2869
[54] Yui N, Katoono R, Yamashita A. Inclusion Polymers. Adv. Polym. Sci., 2009, 222: 55-77
[55] Yamada Y, Nomura T, Harashima H, Yamashita A, Katoono R, Yui N. Biol. Pharm. Bull., 2010, 33: 1218-1222
[56] Liu Y, Yu L, Chen Y, Zhao Y L, Yang H. J. Am. Chem. Soc., 2007, 129: 10656-10657
[57] Ke C F, Hou S, Zhang H Y, Liu Y, Yang K, Feng X Z. Chem. Commun., 2007, 3374-3376
[58] Mammen M, Choi S K, Whitesides G M. Angew. Chem. Int. Ed., 1998, 37: 2755-2794
[59] Belitsky J M, Nelson A, Hernandez J D, Baum L G, Stoddart J F. Chem. Biol., 2007, 14: 1140-1151
[60] Nelson A, Belitsky J M, Vidal S, Joiner C S, Baum L G, Stoddart J F. J. Am. Chem. Soc., 2004, 126: 11914-11922
[61] Wenz G, Han B H, Muller A. Chem. Rev., 2006, 106: 782-817
[62] Yui N, Ooya T, Kawashima T, Saito Y, Tamai I, Sai Y, Tsuji A. Bioconjugate Chem., 2002, 13: 582-587
[63] Luo H Y, Liu Y, Yu Z J, Zhang S, Li B J. Biomacromolecules, 2008, 9: 2573-2577
[64] Joung Y K, Sengoku Y, Ooya T, Park K D, Yui N. Sci. Technol. Adv. Mater., 2005, 6: 484-490
[65] Park H D, Lee W K, Ooya T, Park K D, Kim Y H, Yui N. J. Biomed. Mater. Res., 2002, 60: 186-190
[66] Parl H D, Lee W K, Ooya T, Park K D, Kim Y H, Yui N. J. Biomed. Mater. Res. A, 2003, 66A: 596-604
[67] Liu Y, Zhao Y L, Chen Y, Wang M. Macromol. Rapid Commun., 2005, 26: 401-406
[68] Akiyama Y, Lueβen H L, de Boer A G, Verhoef J C, Junginer H E. Int. J. Pharm., 1996, 138: 13-23
[69] Eguchi M, Ooya T, Yui N. J. Control. Release, 2004, 96: 301-307
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