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化学进展 2011, Vol. 23 Issue (12): 2550-2559 前一篇   后一篇

• 综述与评论 •

取向结构和梯度分布医用材料的制备及应用

邢东明, 马列*, 高长有*   

  1. 教育部高分子合成与功能构造重点实验室 浙江大学高分子科学与工程学系 杭州 310027
  • 收稿日期:2011-03-01 修回日期:2011-06-01 出版日期:2011-12-24 发布日期:2011-09-29
  • 作者简介:e-mail:liema@zju.edu.cn; cygao@mail.hz.zj.cn
  • 基金资助:

    国家自然科学基金项目(No.20934003)和国家重点基础研究发展计划(973)项目(No.2011CB606203)资助

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Preparation and Applications of Ordered and Gradient Scaffolds in Regenerative Medicine

Xing Dongming, Ma Lie*, Gao Changyou*   

  1. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
  • Received:2011-03-01 Revised:2011-06-01 Online:2011-12-24 Published:2011-09-29
组织器官缺损或功能损失是人类健康所面临的重大危害,具有特定结构和组成的再生医学材料是实现组织再生与修复的关键和物质基础。本文对具有取向结构和梯度分布的再生医学材料的制备方法及其生物学性能进行了综述。与传统的再生医学材料相比,取向结构使得细胞在支架中呈取向分布和生长,有利于营养物质及代谢产物的传递,可用于构建具有取向结构的三维组织。具有物理性能、化学组成、生物因子梯度分布的再生医学材料能够调控细胞在梯度方向的黏附、迁移和分化等行为。基于仿生学原理设计的具有取向结构和梯度分布的再生医学材料为缺损组织或器官的再生与修复提供了更适宜的微环境,可望获得更出色的再生修复效果。
关键词： 支架, 取向, 梯度, 再生医学
The tissue loss or organ failure, resulting from trauma or diseases, is a major concern in human healthcare. The recent development of regenerative medicine by combing the cells and degradable scaffolds offers a unique pathway to recreate tissues and organs with high bioactivity and biomimetic structures. This article reviews the state-of-art of the ordered and gradient scaffolds in terms of their preparation methods and biological performance. In contrast with the homogeneous counterpart, the ordered scaffolds facilitate delivery of nutrients and metabolites, and can guide cell growth, distribution and new tissue formation in vitro, leading to construction of 3D-engineered tissues with ordered cells and extracellular matrix. On the other hand, the gradient cues (e.g. physical, chemical and biological properties) incorporated into the 3D scaffolds can create a microenvironment governing the cell behaviors such as migration rate and direction as well as differentiation, and thereby guiding the tissue regeneration. The methods of phase separation, electrospinning, injection and centrifugation are usually employed to prepare the ordered and gradient 2D substrate and 3D scaffolds. The biological performance of these scaffolds is discussed. Wish such a structure mimicking the native tissue-like environment, the scaffolds are expected to show exceptional advantages in regeneration of tissues and organs of better functions and structures. Contents 1 Introduction 2 Ordered regenerative medicine materials and their preparation 2.1 Phase separation/directional freeze-drying 2.2 Electrospinning 2.3 Other methods 3 Gradient regenerative medicine materials and their preparation 3.1 Cell migration and gradient surface 3.2 Preparation of 3D gradient medical material 4 Conclusion and perspectives
Key words: scaffolds, orientation, gradient, regenerative medicine

中图分类号: 

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