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化学进展 2011, Vol. 23 Issue (12): 2541-2549 前一篇   后一篇

• 综述与评论 •

温度响应性单分子聚合物胶束

罗时忠*, 韩梦成, 曹月辉, 凌从祥   

  1. 安徽师范大学化学与材料科学学院 安徽省功能性分子固体重点实验室 安徽省分子基材料重点实验室 芜湖 241000
  • 收稿日期:2011-04-01 修回日期:2011-06-01 出版日期:2011-12-24 发布日期:2011-09-29
  • 作者简介:e-mail:shzhluo@mail.ahnu.edu.cn
  • 基金资助:

    国家自然科学基金项目(No.20704001)和安徽省自然科学基金项目(No.070414191)资助

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Thermoresponsive Unimolecular Polymeric Micelles

Luo Shizhong*, Han Mengcheng, Cao Yuehui, Ling Congxiang   

  1. Anhui Key Laboratory of Functional Molecular Solids and Anhui Key Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China
  • Received:2011-04-01 Revised:2011-06-01 Online:2011-12-24 Published:2011-09-29
单分子聚合物胶束和传统的胶束一样具有核-壳结构,因其结构固定并具有良好的热力学稳定性而越来越受到研究者的关注。当这类胶束的核层或者壳层含有温敏性高分子的时候就可以形成具有温度响应性的单分子聚合物胶束。近年来,人们在温敏性的单分子聚合物胶束的合成与性能研究方面做了大量的工作。本文概述了具有温度响应行为的单分子聚合物胶束的类型、制备方法以及应用等方面取得的新进展,同时结合本实验室的工作,总结了基于超支化大分子的温敏性单分子聚合物胶束的相转变行为研究,并对这类胶束体系的发展进行了展望。
关键词： 温度响应, 单分子聚合物胶束, 超支化大分子, 相转变
Unimolecular polymeric micelles consist of a core-shell architecture that resembles conventional micellar structures but with significant thermodynamic stability in aqueous solutions. The core or shell of the micelles consisting of temperature-sensitive polymers can form the thermoresponsive unimolecular polymeric micelles which have attracted much interest recently due to their unique structures and potential applications. There are more and more papers present the synthesis and performance of the navel micelles in recent years. This review details the types, preparation as well as application of the thermorsensitve unimolecular polymeric micelles. The summary for the phase transition behavior of the micelles based on hyperbranched polymers has been represented here. Furthermore, the future development trend of thermoresponsive unimolecular polymeric micelles is also discussed. Contents 1 Introduction 2 Types of thermoresponsive unimolecular polymeric micelles 2.1 Cross-linked micelles 2.2 Multiarm star-like unimolecular polymeric micelles 3 Preparation of thermoresponsive unimolecular polymeric micelles 3.1 Self-assembly micelles 3.2 Unimolecular polymeric micelles based on hyperbranched polymers 3.3 Inorganic template method 4 Phase transition behavior of thermoresponsive unimolecular polymeric micelles 4.1 Unimolecular polymeric micelles with a hydropho-bic hyperbranched core 4.2 Unimolecular polymeric micelles with a hydro-philic hyperbranched core 5 Application of thermoresponsive unimolecular polymeric micelles 5.1 Drug delivery 5.2 Non-viral gene vectors 5.3 Thermoresponsive hybrid nanoparticles 6 Conclusion and outlook
Key words: thermoresponsive, unimolecular polymeric micelles, hyperbranched polymer, phase transition

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摘要

温度响应性单分子聚合物胶束