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RAFT聚合法制备聚合物胶束及其应用前景

杨正龙, 周丹, 陈秋云   

  1. 同济大学材料科学与工程学院 先进土木工程材料教育部重点实验室 上海市特殊人工微结构材料与技术重点实验室 上海 200092
  • 收稿日期:2011-03-01 修回日期:2011-05-01 出版日期:2011-11-24 发布日期:2011-08-30
  • 通讯作者: 杨正龙 E-mail:yangzhenglong@tongji.edu.cn
  • 基金资助:

    国家自然科学基金项目(No.50703029),上海市青年科技启明星计划资助(No.09QA1406300),国家环境保护公益性行业科研专项项目(No.2012467026),中央高校基本科研业务费专项基金(No.20110214)同济大学先进土木工程材料教育部重点实验室青年基金(No.2010104)和上海市金属功能材料重点实验室开放基金(No.2009106)资助

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Preparation and Potential Application of Polymeric Micelles via RAFT Polymerization

Yang Zhenglong, Zhou Dan, Chen Qiuyun   

  1. School of Materials Science and Engineering, Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology, Tongji University, Shanghai 200092, China
  • Received:2011-03-01 Revised:2011-05-01 Online:2011-11-24 Published:2011-08-30
  • Contact: YANG Zheng-long E-mail:yangzhenglong@tongji.edu.cn

聚合物胶束由于具有优良的组织渗透性、增容效果好、结构多样性和热稳定性等特点,成为国内外研究的热点之一。本文综述了近几年发展起来的一些具有特殊结构和特殊性能的双亲性嵌段聚合物胶束的研究进展,详细阐述了RAFT聚合法合成聚合物胶束的机理和优势,表明了RAFT聚合法可直接在水溶液中方便快捷地制备出温度和pH双响应性聚合物胶束。然而,当聚合物胶束的浓度低于其临界胶束浓度时,胶束的稀释效应大大影响了其实际应用,为提高聚合物胶束的稳定性,文章归纳总结了一系列有关壳交联聚合物胶束的制备方法及研究进展。最后,文章展望了聚合物胶束在药物可控释放、靶向、生物成像、催化剂负载及其他领域的应用前景。

关键词： RAFT聚合法, 壳交联, 聚合物胶束, 稳定性, 应用前景

The rapid progress of polymeric micelles, which due to their attractive advantages such as excellent tissue permeability, compatibilization effect, structural diversity and thermal stability, has raised interest in recent years. In this review, the research progress of amphiphilic block copolymer micelles with special structure and special properties is discussed. The formation mechanism and advantage of polymeric micelles via RAFT polymerization method are introduced. Different thermo- and pH-responsive micelles can be prepared quickly and easily in aqueous solution via RAFT polymerization method. However, dilution effect of polymer micelles greatly affect its practical application when the concentration of the polymer micelle below its critical micelle concentration. To improve the stability of polymer micelles, several methods to prepare polymeric cross-linked micelles are summarized. Finally, the current challenges for the polymeric micelles potential applications in controlled drug release, targeting, biological imaging, catalyst immobilization and other areas are highlighted.

Contents
1 Introduction
2 The RAFT polymerization mechanism
3 Methods to prepare polymeric cross-linked micelles
4 Potential applications of polymeric micelles
4.1 Polymeric micelles for controlled drug release
4.2 Polymeric micelles for drug targeting
4.3 Polymeric micelles for biological imaging
4.4 Polymeric micelles for catalyst immobilization and other area
5 Summary and outlook

Key words: RAFT polymerization, shell cross-linked, polymeric micelles, stability, potential application

中图分类号: 

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