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化学进展 2011, Vol. 23 Issue (10): 2140-2150 前一篇   后一篇

• 综述与评论 •

分子印迹水相分离技术及其在分析化学中的应用

张慧1, 何华1,2*, 李洁1, 李卉1, 姚誉阳1   

  1. 1. 中国药科大学分析化学教研室 南京 210009;
    2. 药物质量与安全预警教育部重点实验室 南京 210009
  • 收稿日期:2011-01-01 修回日期:2011-03-01 出版日期:2011-10-24 发布日期:2011-09-15
  • 作者简介:e-mail:dochehua@163.com
  • 基金资助:

    “新药创制”重大专项(No.2009ZX09301-006)、中央高校基本科研业务费专项资金(No.JKY2009059)和浙江省自然科学基金项目(No.Y4110235)资助

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导出 被引次数 ( 67 | 6 )

Water-Compatible Molecular Imprinting Separation Technique and Its Application in Analytical Chemistry

Zhang Hui1, He Hua1,2*, Li Jie1, Li Hui1, Yao Yuyang1   

  1. 1. Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, China;
    2. Key Laboratory of Drug Quality Control and Pharmacovigilance,Ministry of Education, Nanjing 210009, China
  • Received:2011-01-01 Revised:2011-03-01 Online:2011-10-24 Published:2011-09-15

分子印迹分离技术通过模拟抗体-抗原相互作用原理,专一地与目标分子互补性结合,从而将目标分子与杂质分离,是一种非常具有发展前景的分离技术。传统的分子印迹技术通常是在有机相中制备对印迹分子具有选择性的印迹聚合物,然而分子印迹技术的实际应用环境大多是水相体系。近年来,分子印迹水相分离技术受到了科学工作者的广泛关注。本文分别从以下几个方面总结了分子印迹水相分离技术的最新研究进展:水相中分子印迹聚合物的设计原理与合成方法;印迹聚合物在水相中的作用机制;印迹水相分离技术在分析化学中的应用。最后讨论了该项技术现存的问题,并对其未来发展进行了展望。

关键词： 分子印迹技术, 水相分离, 分子印迹聚合物

Molecular imprinting separation technique can effectively separate the target molecules from impurities by specially binding the target molecules based on imitating the way of interaction between antigen and antibody. It is a very promising separation technique. In the traditional molecular imprinting techniques, imprinted polymers are usually prepared for selectively adsorbing the template molecule in organic solvents. However, most of the practical applications of molecular imprinting technique are in aqueous media. Thus, molecular imprinting separation technique in aqueous media receives more and more attention by scientific researchers in recent years. This review covers the recent progress of molecular imprinting separation technique from the following directions: design principle and synthesis methods of imprinted polymers in aqueous media; separation mechanism of water-compatible molecularly imprinted polymers; applications of water-compatible molecular imprinting separation technique in analytical chemistry. Moreover, the existing problems and the outlook of this technique are discussed.

Contents
1 Introduction
2 Preparation of molecularly imprinted polymers in aqueous media
2.1 Water-compatible bulk polymerization
2.2 Water-compatible spherical polymerization
2.3 Water-compatible surface molecular imprinted polymerization in water system
2.4 Preparation of water-compatible molecularly imprinted polymer nanowires
3 Recognition mechanism of water-compatible molecularly imprinted polymers
3.1 Water-compatible molecularly imprinted polym-ers based on electrostatic interaction
3.2 Metal-ion imprinted polymers
3.3 Cyclodextrin molecularly imprinted polymers
4 Application of water-compatible molecular imprin-ting technique in analytical chemistry
4.1 Water-compatible molecularly imprinted sample preparation techniques
4.2 Application in the analysis of trace constituents
4.3 Application in the chiral separation
5 Conclusion and outlook

Key words: molecular imprinting technique, water-phase separation, molecularly imprinted polymers(MIP)

中图分类号: 

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