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化学进展 2011, Vol. 23 Issue (10): 2132-2139 前一篇   后一篇

• 综述与评论 •

离子液与蛋白质和核酸相互作用的研究

张涛1, 陈凡1, 盖青青1, 屈锋1*, 张玉奎2   

  1. 1. 北京理工大学生命学院 北京 100081;
    2. 中国科学院大连化学物理研究所 大连 116023
  • 收稿日期:2011-01-01 修回日期:2011-03-01 出版日期:2011-10-24 发布日期:2011-09-15
  • 作者简介:e-mail:qufengqu@bit.edu.cn
  • 基金资助:

    国家重点基础研究发展计划(973)项目(No.2007CB914101)和国家自然科学基金项目(No.20875009)资助

下载PDF ( 1214 ) 引用
导出 被引次数 ( 8 | 2 )

Ionic Liquids and Protein/Nucleic Acid Interaction

Zhang Tao1, Chen Fan1, Gai Qingqing1, Qu Feng1*, Zhang Yukui2   

  1. 1. School of Life Science, Beijing Institute of Technology, Beijing 100081, China;
    2. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
  • Received:2011-01-01 Revised:2011-03-01 Online:2011-10-24 Published:2011-09-15

离子液因其具有良好的生物兼容性和独特的理化性质,近年来在生物催化和生物大分子蛋白质与核酸的分离分析领域得到广泛应用。离子液与生物大分子相互作用的研究是离子液相关理论与应用研究的基础,有关离子液与蛋白质和核酸相互作用的机理研究受到关注。本文简要介绍了常用离子液的分类,离子液与蛋白质分子作用的机理,离子液与核酸分子作用的机理,以及离子液在酶催化反应、生物分子分离、生物分子电化学分析和毛细管电泳分析中的应用,并主要综述了近年的相关研究和应用进展。

关键词： 离子液, 蛋白质, 核酸, 相互作用

Room-temperature ionic liquids(ILs)have aroused considerable interest recent years. They have been widely applied in biological catalysis and proteins and nucleic acids separation due to their good compatibility and unique properties. The interaction of ionic liquids and biological macromolecules is the foundation of their theory and application study. In this paper, the types of common used ILs, the principle of interaction between ionic liquids and protein, and ionic liquids and nucleic acid are introduced respectively. Furthermore, the recent application of ILs in biological catalysis, biological molecules separation electrochemical analysis as well as capillary electrophoresis analysis is reviewed.

Contents
1 Introduction
2 Type of ILs
3 Interaction between ILs and protein
3.1 Electrostatic interaction
3.2 Hydrophobic interaction
3.3 Hydrogen bond interaction
3.4 Coordination interaction
4 Interaction between ILs and nucleic acid
4.1 Electrostatic interaction
4.2 Hydrophobic interaction
4.3 Hydrogen bond interaction
5 Application of ILs based on the interaction between protein and nucleic acid
5.1 Enzyme-catalyzed reaction
5.2 Extraction separation
5.3 Electrochemical analysis
5.4 Separation and analysis in CE
6 Outlook

Key words: ionic liquids, protein, nucleic acids, interaction

中图分类号: 

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