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化学进展 2011, Vol. 23 Issue (10): 2119-2131 前一篇   后一篇

• 综述与评论 •

G-四链体-氯化血红素DNA酶在传感器设计中的应用

孔德明*   

  1. 南开大学化学院分析科学研究中心 天津 300071
  • 收稿日期:2011-01-01 修回日期:2011-02-01 出版日期:2011-10-24 发布日期:2011-09-15
  • 作者简介:e-mail:kongdem@nankai.edu.cn
  • 基金资助:

    天津市应用基础及前沿技术研究计划项目(No. 08JCZDJC21200)资助

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导出 被引次数 ( 7 | 3 )

Applications of G-Quadruplex-Hemin DNAzymes in Sensor Design

Kong Deming*   

  1. Research Centre for Analytical Sciences, Department of Chemistry, Nankai University, Tianjin 300071, China
  • Received:2011-01-01 Revised:2011-02-01 Online:2011-10-24 Published:2011-09-15

G-四链体-氯化血红素(hemin)DNA酶是一种由特定的核酸G-四链体与hemin结合后形成的具有过氧化物酶活性的人工模拟酶。作为一类重要的DNA酶,G-四链体-hemin DNA酶近年来在分析化学领域受到了越来越多的关注。目前这类DNA酶已被用在了多种传感器,包括金属离子传感器、适配体传感器、酶传感器、DNA传感器及药物传感器的设计当中。本文对G-四链体-hemin DNA酶在传感器设计中的应用进行了系统的介绍和评述,并对其未来的发展进行了初步的展望。

关键词： DNA酶, G-四链体, 氯化血红素, 传感器, 过氧化物酶

G-quadruplex-Hemin DNAzymes are a kind of peroxidase-like artificial enzymes formed by nucleic acid G-quadruplexes and Hemin. As an kind of important DNAzymes, G-quadruplex-hemin DNAzymes have attracted more and more attention in analytical chemistry in these years. G-quadruplex-hemin DNAzymes have been used in the design of several sensors, such as metal ion sensors, aptasensors, enzyme sensors, DNA sensors and drug sensors. This paper provides an overview of the progress of G-quadruplex-hemin DNAzyme-based sensors and the design strategies are introduced in detail. In addition, the future development of this kind of DNAzymes is prospected.

Contents
1 Introduction
2 Metal ion sensors
2.1 K+ sensors
2.2 Hg2+ sensors
2.3 Ag+ sensors
2.4 Pb2+ sensors
2.5 Cu2+ sensors
3 Aptasensors
4 Enzyme sensors
4.1 Telomerase sensors
4.2 Methyltransferase sensors
5 DNA sensors
5.1 Homogenous DNA sensors
5.2 Heterogenous DNA sensors
6 Drug sensors
7 Prospect

Key words: DNAzyme, G-quadruplex, hemin, sensors, peroxidase

中图分类号: 

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