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化学进展 2010, Vol. 22 Issue (12): 2450-2461 前一篇   后一篇

• 综述与评论 •

生物制造2,3-丁二醇:回顾与展望

纪晓俊, 聂志奎, 黎志勇, 高振, 黄和   

  1. 南京工业大学生物与制药工程学院材料化学工程国家重点实验室 南京 210009
  • 出版日期:2010-12-24 发布日期:2010-11-04
  • 作者简介:e-mail:biotech@njut.edu.cn
  • 基金资助:

    国家自然科学基金项目(No. 20606018)、国家高技术研究发展计划(863)项目(No. 2006AA02Z244)和国家重点基础研究发展计划(973)项目(No. 2007CB707805)资助

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Biotechnological Production of 2,3-Butanediol

Ji Xiaojun, Nie Zhikui, Li Zhiyong, Gao Zhen, Huang He   

  1. State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China
  • Online:2010-12-24 Published:2010-11-04

2,3-丁二醇是生物制造产品体系中一种重要的精细化工原料和潜在平台化合物,广泛应用于材料、医药、食品及航空航天等领域。利用生物质可再生资源为原料生产2,3-丁二醇符合当前发展低碳经济的国家需求。本文回顾了生物制造2,3-丁二醇的研究历史,分析了微生物合成2,3-丁二醇的代谢机理,总结了提高生物制造2,3-丁二醇经济性的有效途径,包括廉价原料的替代、菌株选育与遗传改造和发酵过程控制等,并对2,3-丁二醇的各种下游分离过程进行了对比分析;指出今后研究重点应着眼于努力提高生物质的利用效率,同时实现高效的2,3-丁二醇生物转化两方面,并在此基础上开发2,3-丁二醇的系列高值衍生物,以进一步拓展其应用领域。

关键词： 2, 3-丁二醇 生物质可再生资源 发酵 分离

2,3-Butanediol, which is considered as an important fine and potential platform chemical, has been widely used in many fields such as materials, medicine, foods, aeronautics, astronautics and so on. Biotechnological production of 2,3-butanediol has a long history over 100 years. Recently, microbial 2,3-butanediol production has attracted great attention as this means which depends on renewable bioresources is a promising route for developing low carbon economy and a gateway to a more sustainable future. In this review, the history of 2,3-butanediol fermentation is revisited and the metabolic mechanism of microbial 2,3-butanediol accumulation and the related key genes and enzymes are firstly introduced. Some strategies for efficient and economical 2,3-butanediol production, including using alternative cost-effective substrates to reduce the raw materials cost, strain improvement for enhancing the 2,3-butanediol yield and process development for improving the bioprocessing ecnomics, are then summarized. At last, various downstream separation methods for economical 2,3-butanediol recovering process are compared. It is pointed out that the focus of future research should be placed on improving biomass utilizing efficiency and enhancing 2,3-butanediol titer, also series of value-added 2,3-butanediol derivatives could be exploited to further expand its applications.

Contents
1 Introduction
2 Current status of 2,3-butanediol production and its application
3 Microbial 2,3-butanediol production and its physiological function
3.1 Microorganisms producing 2,3-butanediol
3.2 Metabolic pathway, key genes and enzymes involved in 2,3-butanediol biosynthesis
3.3 Physiological function of 2,3-butanediol in microbial metabolism
4 Strategies for efficient and economical 2,3-butanediol production
4.1 Alternative fermentation substrates
4.2 Strain improvement and genetic engineering
4.3 Process development
5 Downstream processing of 2,3-butanediol
6 Conclusion and prospects

Key words: 2,3-butanediol, renewable bioresources, fermentation, separation

中图分类号: 

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生物制造2,3-丁二醇:回顾与展望