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化学进展 2010, Vol. 22 Issue (12): 2436-2449 前一篇   后一篇

• 综述与评论 •

方剂的化学成分及药效物质

秦昆明1, 蔡皓1, 张丽2, 石芸1, 李萍3, 蔡宝昌1   

  1. 1. 南京中医药大学 教育部中药炮制规范化及标准化工程研究中心 南京 210029;
    2. 南京中医药大学 江苏省方剂研究重点实验室 南京 210046;
    3. 中国药科大学 现代中药教育部重点实验室 南京 210038
  • 出版日期:2010-12-24 发布日期:2010-11-04
  • 作者简介:e-mail:bccai@126.com
  • 基金资助:

    国家自然科学基金项目(No.90709025)和国家中医药管理局公益性行业科研专项(No.201007010)资助

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Chemical Constituents and Effective Substances of Traditional Chinese Medicinal Formula

Qin Kunming1, Cai Hao1, Zhang Li2, Shi Yun1, Li Ping3, Cai Baochang1   

  1. 1. Engineering Research Center of Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210029, China;
    2. Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing 210046, China;
    3. Key Laboratory of Modern Chinese Medicine of Ministry of Education, China Pharmaceutical University, Nanjing 210038, China
  • Online:2010-12-24 Published:2010-11-04

方剂是中医临床用药的主要形式,是中医理论整体观和辨证施治的最佳体现,在整个中医药体系中占有举足轻重的地位;由于化学成分不清楚,作用机理不明确,方剂的国际化在很大程度上受到了限制。方剂的化学成分和药效物质研究是中医药现代化研究的两个重要组成部分。近年来,多种生物技术和分析化学方法为方剂化学成分和药效物质研究提供了新的方法和技术。本文在总结方剂化学成分和药效物质基础研究现状的基础上,提出了进一步深入研究的基本思路。

关键词： 方剂, 化学成分, 药效物质

Traditional Chinese medicinal formula(TCMF) is an important clinic guide for application of Chinese medicines. It is a reflection of both diagnosis and treatment of traditional Chinese medical theory, occupying a pivotal position in the system of Chinese medicine. At present, TCMF is facing difficulties because its curative effects are largely based on the prescribing doctor's experience and its effective constituents and mechanisms of action are unclear, which seriously restricts their development in the international market. Chemical constituents and effective substance basis of TCMF are two important parts of the study of Chinese medicines. In the recent years, the development of modern biological and analytical techniques have provided new techniques and approaches for the modern studies on chemical constituents and effective substances in TCMF. In this paper, we reviewed the latest progresses of studying the chemical constituents and effective substance basis of TCMF, and put forward basic thoughts on improving research activities in the area.

Contents
1 Introduction
2 Chemical constituents of TCMF
2.1 Chemical isolation and structure identification
2.2 Qualitative analysis
2.3 Quantitative analysis
3 Effective substance basis of TCMF
3.1 Pharmacokinetics of TCMF
3.2 Metabolic components of TCMF
3.3 Biochromatography of TCMF
3.4 Spectrum-effect relationship of TCMF
3.5 High throughput screening of bioactive compounds in TCMF
3.6 Metabonomics of TCMF
4 Problems and countermeasures
4.1 Organic combination of traditional theory and modern science and technology
4.2 Intercross and combination of multi-disciplinary knowledge and theory
4.3 Application of new theories, methods and technologies
5 Conclusion

Key words: traditional Chinese medicinal formula, chemical constituents, effective substances

中图分类号: 

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摘要

方剂的化学成分及药效物质