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化学进展 2010, Vol. 22 Issue (12): 2377-2387 前一篇   后一篇

• 综述与评论 •

点击化学在生物医用高分子中的应用

杨奇志, 刘佳, 蒋序林   

  1. 武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室 武汉 430072
  • 出版日期:2010-12-24 发布日期:2010-11-04
  • 作者简介:e-mail:xljiang@whu.edu.cn
  • 基金资助:

    国家自然科学基金项目(No. 20774068)、高等学校博士学科点新教师基金项目(No. 20070486035)、国家重点基础研究发展计划(973)项目(No. 2005CB623903, 2009CB930300)和国家基础科学人才培养基金项目(J0730426)资助

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导出 被引次数 ( 41 | 3 )

Application of Click Chemistry in Biomedical Polymers

Yang Qizhi, Liu Jia, Jiang Xulin   

  1. College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan 430072, China
  • Online:2010-12-24 Published:2010-11-04

点击化学的概念提出不到10年,由于其反应条件温和,反应效率高,产物后处理简单等诸多优点而备受关注。本文概述了点击化学技术应用于生物医用高分子材料的合成,主要介绍了铜催化叠氮炔环加成(copper-catalyzed azide-alkyne cycloaddition)点击化学合成和制备多功能性和智能响应性高分子用于非病毒高分子基因载体、高分子胶束药物载体和水凝胶控制释放体系等的研究和最新进展,提出了点击化学在生物医用高分子材料合成中应用的主要问题,并对其发展前景进行了展望。

关键词： 点击化学, 非病毒基因载体, 高分子胶束, 水凝胶, 药物载体

Click chemistry has attracted great attentions since its concept was introduced in less than a decade, because the click chemistry reaction can be carried out under mild and simple reaction conditions, resulting in high reaction efficiency with easy post-treatment for the obtained products. In this review, the synthesis of biomedical polymers using click reaction technique is briefly introduced. The progress on preparation via copper-catalyzed azide-alkyne cycloaddition click reaction and application of the multifunctional and intelligent polymers for non-viral polymeric gene carriers, polymeric-micelles for drug delivery and polymer-based hydrogel is summarized. The limitations and prospective applications of the click chemistry technique for synthesis of biomedical polymers are also discussed.

Contents
1 Introduction
2 Application of click chemistry in synthesis of biomedical polymers
2.1 Non-viral polymeric gene vector
2.2 Polymeric micelles for drug delivey
2.3 Polymeric hydrogel for drug controlled release
2.4 Other biomedical materials
3 Outlook

Key words: click chemistry, non-viral gene vector, polymeric micelles, hydrogel, drug delivery

中图分类号: 

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