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化学进展 2010, Vol. 22 Issue (11): 2191-2198 前一篇   后一篇

• 综述与评论 •

太赫兹技术在药物化学研究领域中的应用*

刘晓鸿  赵红卫**  刘桂锋  张增艳  吉特  吴胜伟    

  1. （中国科学院上海应用物理研究所 上海  201800）
  • 收稿日期:2010-01-31 修回日期:2010-05-27 出版日期:2010-11-24 发布日期:2010-10-20
  • 通讯作者: 赵红卫 E-mail:zhaohongwei@sinap.ac.cn
  • 基金资助:

    国家自然科学基金；国家重点基础研究发展计划（973）；中国科学院领域前沿项目

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Application of Terahertz Technology in the Pharmaceutical Setting

Liu Xiaohong  Zhao Hongwei**  Liu Guifeng  Zhang Zengyan   Ji Te   Wu Shengwei     

  1. (Shanghai Institute of Applied Physics, Chinese Academy of Science, Shanghai 201800, China)
  • Received:2010-01-31 Revised:2010-05-27 Online:2010-11-24 Published:2010-10-20
  • Contact: ZhaoHongwei E-mail:zhaohongwei@sinap.ac.cn

太赫兹(THz)技术及其应用研究近些年发展迅速，许多研究表明该技术在国防安全、信息通信、材料、环境、化学和生物医学等领域有巨大的应用前景。本文就近年来利用太赫兹光谱和太赫兹成像技术在药物化学领域中的应用研究进行综述。介绍了太赫兹时域光谱技术（THz-TDS）在药物活性成分（Active Pharmaceutical Ingredients, APIs）的检测、异构体的区分、药物的多晶型和假多晶型的鉴别以及混合物的定性与定量分析等方面取得的研究成果和进展；阐述了太赫兹成像技术在分析药物的物理化学性质和包衣膜厚度、密度、结构特性，以及监测产品的一致性和完整性方面的应用优势。此外，还介绍了太赫兹技术在药物动力学研究及药物生产过程分析中的创新性应用研究。

关键词： 太赫兹（THz）, 太赫兹光谱, 太赫兹成像, 药物活性成分（APIs）, 生产过程分析技术（PAT）

Terahertz (THz) technology and its applications are now advancing rapidly. This has resulted in a number of promising applications in the fields of homeland security, information and communications, condensed mater physics, global environmental monitoring, nondestructive evaluation, physical and analytical chemistry, biology and medical sciences and many others. THz technology including terahertz time-domain spectroscopy (THz-TDS) and terahertz imaging has great potential in pharmaceutical industry, because it can provide rich and useful information that helps us to understand the structure and property of molecules from a new electromagnetic wave window. The innovative progresses in the application of THz technology in the pharmaceutical setting in recent years are reviewed with illustrative examples in this paper. THz-TDS has the capability to characterize and quantify the active pharmaceutical ingredients (APIs) in drug materials and final solid dosage forms and to investigate crystallinity, polymorphism, and pseudo-polymorphism. THz functional imaging can be used to nondestructively analyze the tablet matrix physicochemical composition, coating thickness, density and internal structure, and the uniformity and integrity of the coat in solid dosage forms due to the pulsed, coherent and frequency-dependent penetration nature of the radiation. The applications of THz technology in reaction dynamics and as an on-line process analytical technology (PAT) are also discussed in this review.

Contents
1 Introduction
2 Terahertz time-domain spectroscopy
2.1 Investigation of isomers
2.2 Investigation of polymorphism and crystallinity
2.3 Pseudo-polymorphism qualification and quantification
2.4 Quantitative monitoring of reaction processes
3 Terahertz imaging
3.1 Nondestructive analysis of tablet coating
3.2 Nondestructive investigation of druy dissolution performance
3.3 Nondestructive inspection of pharmaceutical ingredients
4. Outlook

Key words: terahertz (THz), terahertz spectroscopy, terahertz imaging, active pharmaceutical ingredients (APIs), process analytical technology (PAT)

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