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化学进展 2010, Vol. 22 Issue (0203): 440-448 前一篇   后一篇

• 综述与评论 •

植物内生真菌抗植物病原真菌活性物质的研究*

马养民1**;赵洁1;周雪宁2   

  1. （1.教育部轻化工助剂化学与技术重点实验室 陕西科技大学 西安 710021；2. 陕西中医学院附属医院 咸阳712000）
  • 收稿日期:2009-06-12 修回日期:2009-08-20 出版日期:2010-03-24 发布日期:2010-03-18
  • 通讯作者: 马养民 E-mail:mym63@sina.com
  • 基金资助:

    无花果内生真菌中抑制植物病原菌活性物质的研究;植物内生真菌中抗生素类代谢产物的研究

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Anti-Plant Pathogenic Fungal Compounds from Endophytic Fungi

Ma Yangmin1**; Zhao Jie1; Zhou Xuening2   

  1. （1. Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education. Shaanxi University of Science & Technology, Xi'an 710021, China; 2. Affiliated Hospital of Shaanxi College of Traditional Chinese Medicine, Xianyang 712000, China)
  • Received:2009-06-12 Revised:2009-08-20 Online:2010-03-24 Published:2010-03-18
  • Contact: Ma Yangmin E-mail:mym63@sina.com

植物内生真菌的代谢产物中存在一系列具有多样性结构的抗植物病原真菌的活性化合物(AFC)。本文以化合物结构为线索，对植物内生真菌所产生的具有抗植物病原真菌活性的生物碱、肽类、萜类、甾体、醌、有机酸、酯类等化合物的结构、对病原菌的抑制效果，及其寄主植物等几方面进行了总结。从3个方面简单介绍了农用抗生素的作用机制，即作用于真菌细胞壁、细胞膜，以及抑制真菌蛋白质的生物合成。最后对AFC作为新型农用抗生素来源的前景进行了展望，其具有作为先导化合物，开发高效、低毒、无公害农用抗生素的巨大潜力。

关键词： 内生真菌, 代谢产物, 抗植物病原真菌活性

A number of anti-plant pathogenic fungi natural compounds (AFCs) with diverse structures have been isolated from endophytic fungi. Progress of studies on AFC is summarized as follows: the host plants of these endophytic fungi, the isolation and characterization of alkaloids, peptides, terpenoids, steroids, quinones, phenols, esters and other compounds, and their inhibitory effects against plant pathogenic fungi. The mechanism of agricultural antibiotics is also briefly introduced, including targeting on fungal cell wall, cell membranes and restraining biosynthesis of fungal proteins. On this basis, the prospects of AFC as the source of agricultural antibiotics are discussed. They have great potential as lead compounds and of exploiting high-efficiency, low toxin, less-persistent and pollution-free agricultural antibiotics.

Contents
1 Introduction
2 Anti-plant pathogenic fungal compounds(AFC)
2.1 Alkaloids
2.2 Peptides
2.3 Terpenoids
2.4 Steroids
2.5 Quinones
2.6 Phenols
2.7 Esters
2.8 Others
3 The mechanism of antifungal agricultural antibiotics
3.1 The antibiotics target cell wall synthesis
3.2 The antibiotics target cell membrane synthesis
3.3 The antibiotics inhibit or interfere with fungal protein synthesis
4 Conclusion and prospects

Key words: endophytic fungus, metabolites, anti-plant pathogenic fungi activity

中图分类号: 

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