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化学进展 2010, Vol. 22 Issue (01): 186-193 前一篇   后一篇

• 综述与评论 •

肿瘤诊断的MRI造影剂*

王玲昀;陈秋云**;魏斌   

  1. （江苏大学化学化工学院 镇江 212013）
  • 收稿日期:2009-02-23 修回日期:2009-04-01 出版日期:2010-01-24 发布日期:2010-01-07
  • 通讯作者: 陈秋云 E-mail:chenqy@ujs.edu.cn
  • 基金资助:

    江苏省自然基金;江苏大学高级人才基金

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MRI Contrast Agent for the Diagnosis of Tumor

Wang Lingyun;  Chen Qiuyun**;  Wei Bin   

  1. (College of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China)
  • Received:2009-02-23 Revised:2009-04-01 Online:2010-01-24 Published:2010-01-07
  • Contact: Chen Qiuyun E-mail:chenqy@ujs.edu.cn

磁共振成像是临床上常用的无侵入性肿瘤早期诊断手段，常常需要借助造影剂来提高诊断能力。造影剂可缩短质子的弛豫时间，间接地改变质子所产生的信号强度并能改变体内局部组织中水质子的弛豫速率，提高正常与患病部位的成像对比度。本文较系统地评述了目前国内外用于肿瘤成像造影剂的研究进展，并讨论了顺磁性造影剂的发展前景。

关键词： 磁共振成像, 造影剂, 肿瘤

Magnetic resonance imaging is commonly used as clinical non-invasive means in early diagnosis of tumor. It often requires contrast agent to improve the effectiveness of diagnosis. MRI contrast agent can shorten proton relaxation time and change the signal intensity of proton indirectly. It also can change the relaxation rate of the water proton in the sub-regional organizations of the body and improve the imaging contrast between normal and abnormal tissues. In this paper, the research progress of contrast agent was systematically reviewed. The development of paramagnetic contrast agents was discussed.

Contents
1 Introduction
2 The research about MRI contrast agent for cancer detection
2.1 Small molecule paramagnetic contrast agent
2.2 Macromolecular paramagnetic contrast agent
2.3 SPIO particles and ferromagnetic particles
2.4 Nano-structure contrast agent
3 Prospects

Key words: magnetic resonance imaging, contrast agents, tumor

中图分类号: 

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摘要

肿瘤诊断的MRI造影剂*