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化学进展 2010, Vol. 22 Issue (01): 179-185 前一篇   后一篇

• 综述与评论 •

可吸收引导组织再生膜*

任天斌1**;曹春红1;王刚2;苏俭生2;袁伟忠1;任杰1   

  1. （1. 同济大学材料科学与工程学院 纳米与生物高分子材料研究所   上海  200092；2. 同济大学口腔医学院   上海  200072）
  • 收稿日期:2009-02-18 修回日期:2009-03-27 出版日期:2010-01-24 发布日期:2010-01-07
  • 通讯作者: 任天斌 E-mail:rtb002@tongji.edu.cn
  • 基金资助:

    国家自然科学基金项目;上海市科技发展基金重点纳米专项

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Absorbable Guided Tissue Regeneration Membranes

Ren Tianbin1**;  Cao Chunhong1;  Wang Gang2;  Su Jiansheng2;  Yuan Weizhong1;  Ren Jie1   

  1. （1. Institute of Nano and Bio-Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai 200092, China; 2. School of Stomatology, Tongji University, Shanghai 200072, China)
  • Received:2009-02-18 Revised:2009-03-27 Online:2010-01-24 Published:2010-01-07
  • Contact: Ren Tianbin E-mail:rtb002@tongji.edu.cn
  • Supported by:

    National Natural Science Foundation of China

引导组织再生膜（guided tissue regeneration membrane, GTRM）由于能使组织修复再生能力得到最大程度的发挥而广泛应用于各种软硬组织的修复与再生研究及临床医学中。GTRM分为不可吸收与可吸收GTRM，与不可吸收GTRM相比，由于可吸收GTRM越来越多的优点而备受关注。本文阐述了几种常见的可吸收GTRM材料（以胶原为代表的天然生物材料，以聚酯为代表的合成高分子材料和以羟基磷灰石为代表的可降解无机物材料）及其可吸收GTRM在骨缺损、创伤敷料以及防黏连等领域中的主要应用进展，重点综述了可吸收GTRM的主要制备方法——静电纺丝、溶剂浇铸、相转化及其优缺点。

关键词： 可吸收生物膜, 引导组织再生, 静电纺丝, 溶剂浇铸, 相转化

Guided tissue regeneration membrane (GTRM) is widely applied in repair and regeneration of various hard and soft tissues because of improving the tissue regenaretion ability. GTRM is mainly divided into two kinds: non-absorbable and absorbable GTRM. Compared with non-absorbable GTRM, absorbable GTRM is more widely researched and applied for the more and more merits. In this article, the common materials of absorbable GTRM, i.e. natural biomaterials represented by collagen, synthetic polymeric materials represented by polyester and inorganic materials represented by hydroxyapatite are reviewed. And the applications of absorbable GTRM in bone defects, wound dressing, anti-adhesion areas and so forth are also described. The main methods in preparing absorbable GTRM including electrospinning, solvent-casting and phase inversion and the advantages and disadvantages are described emphatically.

Contents
1 Introduction
2 Materials of absorbable GTRM
3 Methods of absorbable GTRM preparation
3.1 Electrospinning
3.2 Solvent-casting
3.3 Phase inversion
3.4 Other methods of absorbable GTRM preparation
4 Application of absorb-able GTRM
5 Conclusion

Key words: absorbable biomembranes, guided tissue regeneration, electrospinning, solvent-casting, phase inversion

中图分类号: 

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摘要

可吸收引导组织再生膜*