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化学进展 2009, Vol. 21 Issue (6): 1199-1206 前一篇   后一篇

• 综述与评论 •

钒酰腙配合物的合成、结构及生物活性

邢婧;周荫庄**   

  1. (首都师范大学   |北京100048)
  • 收稿日期:2008-08-22 修回日期:2008-11-11 出版日期:2009-06-24 发布日期:2009-06-16
  • 通讯作者: 周荫庄 E-mail:zhouyz7813@x263.net
  • 基金资助:

    省级资助

下载PDF ( 1620 ) 引用
导出 被引次数 ( 8 )

Synthesis, Structure and Biological Activity of Vanadium Complexes Containing Acylhydrazone Ligands

Xing Jing; |Zhou Yinzhuang**   

  1. (Department of Chemistry, Capital Normal University, Beijing 100048, China)
  • Received:2008-08-22 Revised:2008-11-11 Online:2009-06-24 Published:2009-06-16
  • Contact: Zhou Yinzhuang E-mail:zhouyz7813@x263.net

以酰腙为配体钒的单核、双核配合物因其结构丰富、生物活性多样而引起广泛关注。目前该领域新配合物的合成、表征和生物活性的研究甚为活跃。本文回顾了近年来钒酰腙配合物的研究状况，主要从以下三个方面进行综述：(1)钒酰腙配合物的合成方法；(2)此类配合物的配位模式；(3)一些单、双核钒酰腙配合物抗变形虫，抗肿瘤，类胰岛素，抑制Na+， K+—ATP酶，与DNA作用的生物活性。文中着重阐述了钒酰腙化合物的结构和生物活性之间的关系。此外，还提出了钒酰腙配合物研究领域的不足之处并对其今后发展方向进行了展望。

关键词： 钒配合物, 酰腙, 合成, 结构, 生物活性

Mononuclear and binuclear vanadium complexes containing acylhydrazone ligands have attracted wide attention since they possess various structures and biological activity. The synthesis, characterization and biological activity of these complexes are of growing interest. The research achievements are worthy of being summarized. This review on vanadium complexes containing acylhydrazone ligands is carried out from the following three aspects: (1) the synthesis of these complexes; (2) coordination environment; (3) various biological activities of some mononuclear and binuclear vanadium complexes containing acylhydrazone ligands , such as anti-amoebic, anti-tumor, and insulin-mimetic, inhibitory action on Na+, K+—ATPase and interaction with DNA. The present review is emphasized on making a summary on the relationship between the structure and biological activity of these complexes. Finally, the scarcities and the developing trend in this field are also depicted.

Contents
1 Synthetic method of vanadium complexes containing acylhydrazone ligands
1.1 Complexes prepared from acylhydrazone
1.2 Complexes prepared from hydrazide
1.3 Complexes prepared from other vanadium complexes containing acylhydrazone ligands
2 The coordination mode of vanadium complexes containing acylhydrazone ligands
2.1 Mononuclear vanadium complexes
2.2 Binuclear vanadium complexes
3 Biological activities of vanadium complexes containing acylhydrazone ligands
3.1 Anti-amoebic activity
3.2 Anti-tumor activity
3.3 Insulin-mimetic activity
3.4 The activity of inhibitory action on Na+, K+—ATPase
3.5 Interaction with DNA
4 Conclusions

Key words: vanadium complexes, acylhydrazone, synthesis, structure, biological activity

中图分类号: 

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