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化学进展 2009, Vol. 21 Issue (12): 2682-2688 前一篇   后一篇

• 综述与评论 •

层状组装：先进药物控释涂层材料的新选择*

孙婕衎;王雪飞;计剑**   

  1. （浙江大学高分子科学与工程学系 教育部高分子合成与功能构造重点实验室 杭州 310027）
  • 收稿日期:2009-03-16 修回日期:2009-03-26 出版日期:2009-12-24 发布日期:2009-12-01
  • 通讯作者: 计剑 E-mail:jijian@zju.edu.cn
  • 基金资助:

    新型生物相容性心血管植入材料的研究;具有内皮原位快速愈合功能的新型心血管植入材料研究

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Layer-by-Layer Assembly: the New Approach for Advanced Drug Release System

Sun Jiekan;  Wang Xuefei;  Ji Jian**   

  1. (Key Laboratory of Macromolecule Synthesis and Functionalization of Minister of Education, Department of Polymer Science and Engineering,  Zhejiang University, Hangzhou 310027, China)
  • Received:2009-03-16 Revised:2009-03-26 Online:2009-12-24 Published:2009-12-01
  • Contact: Ji Jian E-mail:jijian@zju.edu.cn

先进的药物控释体系和医用植入体是生物医用材料研究的重要内容,将两者有机结合构成的结合装置为采用药物控释的手段有效解决医用植入体面临的挑战,提升医用植入体的功能提供了新的可能。基于静电交替组装的层层组装技术具有操作简单，涂层组成、厚度可控，适用组装分子和组装基材种类广泛，利于保持药物活性等一系列优点，已成为先进药物控释涂层材料的新选择。本文从层状组装多层膜构建原位药物控释涂层的方法研究，对药物释放的调控和功能药物涂层研究三个方面对这一技术在该领域的应用进行了简要介绍。系统总结了层状组装作为先进药物控释涂层材料的优势。并针对将药物控释与医用植入体有机结合的要求，对现有层状组装涂层方法的不足和今后发展的方向进行了论述。

关键词： 层层自组装, 层状组装多层膜, 药物控释

The comprising drug releasing components together with functional prosthetic implant provide the new possibility to improve the functionality in prosthetic implant. The layer-by-layer assembly (LBL) method has been regarded as the most attractive method for advanced drug release coating because it possesses extraordinary advantages such as easy operation, fine control over coating’s composition and outstanding capability of constructing wide ranges of biomolecules onto different substrates and so on. This review gives a brief instruction of current research on LBL as a new approach for advanced drug release coatings for biomedical implant. The advantages as well as the challenges of LBL technique for local drug release films are summarized. Future developments in the field are also discussed.

Contents
1 Constructing drug controlled release systems via LBL
1.1 Drugs as a building block in LBL
1.2 Post diffusion
1.3 Pro-drug
1.4 Precursor assembly
2 Release behavior of multilayers
2.1 The effect of multilayer structure
2.2 Stimulus-response release
3 Research of factional multilayers
3.1 Antibacterial multilayers
3.2 Multilayers for revascularization
3.3 Multilayers for gene delivery
4 Prospects

Key words: layer-by-layer assembly, multilayer films, drug controlled release

中图分类号: 

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