English
往期目录
新闻公告
More
化学进展 2009, Vol. 21 Issue (0708): 1644-1654 前一篇   后一篇

• 综述与评论 •

载银缓释型抗菌敷料

温昕;安胜军*;侯志飞;焦展   

  1. （河北化工医药职业技术学院 |石家庄 |050026）
  • 收稿日期:2008-09-02 修回日期:2008-12-17 出版日期:2009-08-24 发布日期:2009-06-30
  • 通讯作者: 安胜军 E-mail:anshjun@yahoo.com
  • 基金资助:

    无;无

下载PDF ( 3755 ) 引用
导出 被引次数 ( 45 | 3 )

Ag-Loaded Sustained Release Antimicrobial Dressings

Wen Xin; |An Shengjun*;  |Hou Zhifei; |Jiao Zhan   

  1. （The Chemical and Pharmaceutical College of Hebei, Shijiazhuang 050026, China）
  • Received:2008-09-02 Revised:2008-12-17 Online:2009-08-24 Published:2009-06-30
  • Contact: An Shengjun E-mail:anshjun@yahoo.com

近10年来，载银缓释型抗菌敷料因其优良特性，在医药、卫生等领域引起科学家们的广泛关注。本文综述了银的抗菌机理和载银缓释型抗菌敷料的缓释机制；重点介绍了目前在国际市场上销售的代表性载银缓释型抗菌敷料的性能，并从载体材料分类角度（如生物高分子、合成高分子、生物和合成高分子共用、有机硅材料）总结了新型载银抗菌敷料的研究进展；最后，讨论了载银抗菌医用敷料在研究和应用中需要解决的问题。

关键词： 抗菌敷料, 银, 缓释, 制备

During recent ten years, Ag-loaded sustained release antimicrobial dressings have been drawn great attention in the fields of medicine and sanitation because of their excellence characteristic. This review highlights the antimicrobial mechanisms and sustained release methods of silver. It emphatically introduces the functions of the primary Ag-loaded sustained release antimicrobial dressings on the international market, and summarizes the progress on the novel Ag-loaded sustained release antimicrobial dressings from the area of material, including biopolymer, synthetic polymer, blended biopolymer and synthetic polymer and silicone materials. Finally, the challenge and problem for the development of Ag-loaded sustained release antimicrobial dressings are discussed.

Contents
1 Introduction
2 Antimicrobial mechanisms of silver
2.1 Antimicrobial mechanisms of silver ion
2.2 Antimicrobial mechanisms of nano-particle silver
3 Sustained release mechanisms of silver ion
3.1 Interaction of electrovalent and coordinate bond
3.2 Adjustion of the hydrophilicity of carrier
3.3 Crosslinking
3.4 Enhancement of the crystallinity degree
3.5 Others
4 Properties of Ag-loaded sustained release antimicrobial dressings on the market
4.1 Biopolymers
4.2 Polyurethanes
4.3 Artificial fibres/polyesters
5 MaterialsW and characters of the novel Ag-loaded sustained release antimicrobial dressings
5.1 Biopolymers
5.2 Synthetic polymer
5.3 Biopolymers and synthetic polymers
5.4 Polysilicone resins
6 Problems and prospects

Key words: antimicrobial dressing, silver, sustained release, preparation

中图分类号: 

()

[ 1 ] 　Kuroyanagi Y, Kim E , Shioya N. J . Burn Care Rehabil . , 1990 ,11 : 106 —115
[ 2 ] 　Qin Y. Polym. Int . , 2008 , 57 : 171 —180
[ 3 ] 　Sezer A D , Hatipoˇglu F , Cevher E , et al . AAPS Pharm. Sci .Tech. , 2007 , 8 (2) : art . no. 39
[ 4 ] 　Simon S , Le T, Phung GS. J . Ind. Microbiol . Biotechnol . , 2006 ,33 : 627 —634
[ 5 ] 　Damm C , Munstedt H. Appl . Phys. , 2008 , 91 : 479 —486
[ 6 ] 　Payne J L , Ambrosio A M. J . Biomed. Mater. Res. Part B : Appl .Biomater. , 2009 , 89 (1) : 223 —241
[ 7 ] 　Lo S F , Hayter M, Chang C J , et al . J . Clin. Nur. , 2008 , 17 :1973 —1985
[ 8 ] 　Silver S , Phung T L , Silver G. J . Ind. Microbiol . Biotechnol . ,2006 , 33 : 627 —634
[ 9 ] 　Lawrence J C. Burns , 1977 , 3 : 186 —193
[10 ] 　Choi Y S , Hong S R , Lee Y M, et al . Biomaterials , 1999 , 20 :409 —417
[11 ] 　Castellano J J , Shafii S M, Ko F , et al . Int . Wound J . , 2007 , 4 :114 —122
[12 ] 　Mi F L , Wu YB , Shyu S S , et al . J . Biom. Mate. Res. , 2001 ,59 : 438 —449
[13 ] 　Kumar R , Münstedt H. Biomaterials , 2005 , 26 : 2081 —2088
[14 ] 　Grier N. Disinfection , Sterilization , and Preservation. Philadelphia: Lea and Febiger , 1983. 375 —389
[15 ] 　Slawson R M, Van D M, Lee H , et al . Plasmid. , 1992 , 27 :72 —79
[16 ] 　Bellantone M, Williams H D , Hench L L. Antimicrob. Agents Chemother. , 2002 , 46 : 1940 —1945
[17 ] 　Klueh U , Wagner V , Kelly S , et al . J . Biomed. Mater. Res. ,2000 , 53 : 621 —631
[18 ] 　Feng Q L , Wu J , Chen G Q , et al . J . Biomed. Mater. Res. ,2000 , 52 : 662 —668
[19 ] 　夏金兰(Xia J L) , 王春(Wang C) , 刘新星(Liu X X) . 中南大学学报: 自然科学版(J . Central South University: Science and Technology) , 2004 , 35 (1) : 31 —38
[20 ] 　Song Y H , Ko K K, Oh I H , et al . Euro. Cells &Mater. , 2006 ,11 : 58
[21 ] 　Sondi I , Salopek-Sondi B. J . Colloid Interface Sci . , 2004 , 275 :177 —182
[22 ] 　Stoimenov K P , Klinger L R , Marchin GL , et al . Langmuir , 2002 ,18 : 6679 —6686
[23 ] 　Amro A N , Kotra P L , Wadu-Mesthrige K, et al . Langmuir , 2000 ,16 : 2789 —2796
[24 ] 　Kim SJ , Kuk E , Yu N K, et al . Nanomedicine , 2007 , 3 : 95 —101
[25 ] 　Mendis E , Rajapakse N , Byun H G, et al . Life Sci . , 2005 , 77 :2166 —2178
[26 ] 　Li P , Li J , Wu C , et al . Nanotechnology , 2005 , 16 : 1912 —1917
[27 ] 　Bowler P , Jacques E , Parsons D. WO 00243743 ,2002
[28 ] 　Bowler P , Parsons D , Walker M. EP 1825841 ,2003
[29 ] 　Chanda M, Rempel GL. Reaction Polymers , 1990 , 12 : 83 —94
[30 ] 　Chen S P , Wu G Z, Zeng H Y. Carbohydrate Polymers , 2005 , 60 :33 —38
[31 ] 　Kuroyanagi Y, Kim E , Kenmochi M, et al . J . Appl . Biomater. ,1992 , 3 : 153 —161
[32 ] 　Hashimoto T, Suzuki Y, Tanihara M, et al . Biomaterials , 2004 ,25 : 1407 —1414
[33 ] 　王孝华(Wang X H) , 聂明(Nie M) . 化学工业与工程(Chemical Industry and Engineering) , 2005 , 22 : 187 —189
[34 ] 　Lee J E , Park J C , Lee K H , et al . Artif . Organs , 2002 , 26 :636 —646
[35 ] 　Kumar R , Münstedt H. Polym. Int . , 2005 , 54 : 1180 —1186
[36 ] 　Ghosh S , Banthia KA. J . Mater. Sci . , 2007 , 42 : 118 —121
[37 ] 　Zhang YW, Peng H S , Huang W, et al . J . Phys. Chem. , 2008 ,112 : 2330 —2336
[38 ] 　Lee Y M, Kim S S , Park M H , et al . J . Mater. Sci . : Mater.Med. , 2000 , 11 : 817 —823
[39 ] 　Scanlon E , Karlsmark T, Leaper D J , et al . Int . Wound J . , 2005 ,2 : 150 —160
[40 ] 　Newman G R , Walker M, Hobot A J , et al . Biomaterials , 2006 ,27 : 1129 —1139
[41 ] 　Childress B , Berceli S , Nelson P , et al . Ann. Plast . Surg. , 2007 ,21 : 598 —602
[42 ] 　Wright J B , Lam K, Hansen D , et al . Am. J . Infect . Control . ,1999 , 27 (4) : 344 —350
[43 ] 　Meaume S , Senet P , Dumas R , et al . Br. J . Nurs. , 2002 , 11(16) : 42 —50
[44 ] 　J? rgensen B , Price P , Andersen K E , et al . Int . Wound J . , 2005 ,2 : 64 —73
[45 ] 　Ulkur E , Oncul O , Karagoz H , et al . Burns , 2005 , 31 : 874 —877
[46 ] 　Mazurak V C , Burrell R E , Tredget E E , et al . Burns , 2007 , 33 :52 —58
[47 ] 　Thomas S , McCubbin P. J . Wound Care , 2003 , 12 : 101 —107
[48 ] 　Muangman P , Chuntrasakul C , Silthram S , et al . J . Med. Assoc.Thai . , 2006 , 89 (7) : 953 —958
[49 ] 　Mu, ller G, Winkler Y, Kramer A. J . Hospital Infection , 2003 , 53 :211 —214
[50 ] 　Yu HJ , Xu X Y, Chen X, et al . J . Appl . Polym. Sci . , 2007 ,103 : 125 —133
[51 ] 　Maneerung T, Rujiravanit R , Tokura S. Carbohydrate Polymers ,2008 , 72 : 43 —51
[52 ] 　Ersek R A , Denton D R. Ann. Plast . Surg. , 1984 , 13 : 482 —487
[53 ] 　Ersek R A , Denton D R. Contemp. Surg. , 1984 , 23 : 83 —93
[54 ] 　Fox C L , Modak SM, Stanford J W, et al . Burns , 1981 , 7 : 295 —297
[55 ] 　Miller L , Hansbrough J , Slater H , et al . J . Burn Care Rehabil . ,1990 , 11 : 35 —41
[56 ] 　Kuroyanagi Y, Kim E , Shioya N. J . Burn Care Rehabil . , 1991 ,12 : 106 —115
[57 ] 　Lu S , Gao W, Gu H Y. Burns , 2008 , 34 : 623 —628
[58 ] 　Qin Y. Int . Wound J . , 2005 , 2 : 172 —176
[59 ] 　Willi P , Chandra P S. Trends Biomater. Artif . Organs , 2004 , 18(1) : 18 —23
[60 ] 　Balassa L L , Prudden J F. Applications of chitin and chitosan in wound healing acceleration , in Chitin , Chitosan and Related Enzymes , San Diego: Academic Press , 1984. 296 —305
[61 ] 　Yu S H , Mi F L , Wu Y B , et al . J . Mem. Sci . , 2003 , 212 :237 —254
[62 ] 　Yu S H , Mi F L , Wu Y B , et al . J . Appl . Polym. Sci . , 2005 ,98 : 538 —549
[63 ] 　Guan M, Ren L , Wu T, et al . J . Appl . Polym. Sci . , 2007 , 105 :1679 —1686
[64 ] 　Qin Y M, Groocock M R. WO 0236866 , 2002
[65 ] 　Pang X, Zhitomirsky I. Surface &Coatings Technology , 2008 , 202 :3815 —3821
[66 ] 　Qin YM, Zhu C J , Chen J , et al . J . Appl . Polym. Sci . , 2006 ,101 : 766 —771
[67 ] 　Qin YM. J . Appl . Polym. Sci . , 1993 , 49 : 727 —731
[68 ] 　Kawai K, Suzuki S , Tabata Y, et al . J . Biomed. Mater. Res. ,2001 , 57 : 346 —356
[69 ] 　Matsuda K, Suzuki S , Issiki N , et al . Biomaterials , 1993 , 14 :1030 —1035
[70 ] 　Rosenkranz H S , Carr H S. Antimicrob Agents Chemother , 1972 , 2 :367 —372
[71 ] 　Choi YS , Hong S R , Lee YM, et al . J . Biomed. Mater. Res. Part B : Appl . Biomater. , 1999 , 48 : 631 —639
[72 ] 　Bromberg L E , Braman V M, Rothstein D M, et al . J . Control .Rel . , 2000 , 68 : 63 —72
[73 ] 　Yoshida K, Tanagewa M, Atsuta M. J . Biomed. Mater. Res. ,1999 , 47 : 516 —522
[74 ] 　Radheshkumar C , Münstedt H. Materials Letters , 2005 , 59 : 1949 —1953
[75 ] 　Kumar R , Howdle S , Münstedt H. J . Biomed. Mater. Res. Part B :Appl . Biomater. , 2005 , 75 : 311 —319
[76 ] 　Damm C , Münstedt H , Rêsch A. Mater. Chem. Phys. , 2008 , 108 :61 —66
[77 ] 　Zan J , Chen H H , Jiang G Q , et al . J . Appl . Poly. Sci . , 2006 ,101 : 1892 —1898
[78 ] 　Kyung H , H. Polym. Eng. Sci . , 2007 , 47 : 43 —49
[79 ] 　Jeon HJ , KimJ S , Kim T G, et al . Appl . Sur. Sci . , 2008 , 254 :5886 —5890
[80 ] 　Kim HJ , Choi E Y, Oh J S , et al . Biomaterials , 2000 , 21 : 131 —141
[81 ] 　Yu D G. Colloids Sur. B : Biointerf . , 2007 , 59 : 171 —178
[82 ] 　LaMer V K. Ind. Eng. Chem. , 1952 , 44 : 1270 —1227
[83 ] 　Ghosh S , Banthia A K. Eur. Polym. J . , 2003 , 39 : 2141 —2146
[84 ] 　Loher S , Schneider D O , Maienfisch T, et al . Small , 2008 , 4 :824 —832
[85 ] 　Eckelman MJ , Graedel T E. Environ. Sci . Technol . , 2007 , 41 :6283 —6289
[86 ] 　Sambhy V , MacBride M M, Peterson B R , et al . J . Am. Chem.Soc. , 2006 , 128 : 9798 —9890
[87 ] 　Damm C , Münstedt H. Surface &Coatings Technology , 2008 , 202 :5122 —5126
[88 ] 　Murthy P S K, Mohan Y M, Varaprasada K, et al . J . Colloid Interface. Sci . , 2008 , 318 : 217 —224
[89 ] 　Lala N L , Ramaseshan R , Bojun L , et al . Biotechnol . Bioeng. ,2007 , 97 : 1357 —1365
[90 ] 　Son W K, Youk J H , Lee T S , et al . Polymer , 2004 , 45 (9) :2959 —2966
[91 ] 　Petica A , Gavriliu S , Lungu M, et al . Mater. Sci . Eng. B , 2008 ,152 (1/3) : 22 —27
[92 ] 　Ma YL , Zhou T, Zhao C S. Carbohydrate Res. , 2008 , 343 : 230 —237
[93 ] 　Lim T S , Martin P G, Berry J D , et al . J . Control . Rel . , 2000 ,66 : 281 —292
[94 ] 　Cho Y S. J . Mater. Sci . : Materials in Medicine , 2002 , 13 : 861 —865
[95 ] 　Min KD , Youk J H , Kwark YJ , et al . Fibers and Polymers , 2007 ,8 : 591 —600
[96 ] 　Jeon HJ , Yi S C , Oh S G. Biomaterials , 2003 , 24 : 4921 —4928
[97 ] 　Cutting K, White R , Edmonds M. Int . Wound J . , 2007 , 4 : 177 —184
[98 ] 　Guillaume C , Michel V , Philippe M, et al . Arch Dermatol . , 2007 ,143 (10) : 1297 —1304
[99 ] 　Chopra I. J . Antim. Chem. , 2007 , 59 : 587 —590
[100 ]  Atiyeh B , Costagliola M, Hayek S , et al . Burns , 2007 , 33 : 139 —148
[1] 王丹丹, 蔺兆鑫, 谷慧杰, 李云辉, 李洪吉, 邵晶. 钼酸铋在光催化技术中的改性与应用[J]. 化学进展, 2023, 35(4): 606-619.
[2] 廖子萱, 王宇辉, 郑建萍. 碳点基水相室温磷光复合材料研究进展[J]. 化学进展, 2023, 35(2): 263-373.
[3] 李璇, 黄炯鹏, 张一帆, 石磊. 二维材料的一维纳米带[J]. 化学进展, 2023, 35(1): 88-104.
[4] 朱月香, 赵伟悦, 李朝忠, 廖世军. Pt基金属间化合物及其在质子交换膜燃料电池阴极氧还原反应中的应用[J]. 化学进展, 2022, 34(6): 1337-1347.
[5] 李芳远, 李俊豪, 吴钰洁, 石凯祥, 刘全兵, 彭翃杰. “蛋黄蛋壳”结构纳米电极材料设计及在锂/钠离子/锂硫电池中的应用[J]. 化学进展, 2022, 34(6): 1369-1383.
[6] 孙浩, 王超鹏, 尹君, 朱剑. 用于电催化析氧反应电极的制备策略[J]. 化学进展, 2022, 34(3): 519-532.
[7] 王才威, 杨东杰, 邱学青, 张文礼. 木质素多孔碳材料在电化学储能中的应用[J]. 化学进展, 2022, 34(2): 285-300.
[8] 曹祥康, 孙晓光, 蔡光义, 董泽华. 耐久型超疏水表面:理论模型、制备策略和评价方法[J]. 化学进展, 2021, 33(9): 1525-1537.
[9] 张震, 赵爽, 陈国兵, 李昆锋, 费志方, 杨自春. 碳化硅块状气凝胶的制备及应用[J]. 化学进展, 2021, 33(9): 1511-1524.
[10] 李金召, 李政, 庄旭品, 巩继贤, 李秋瑾, 张健飞. 纤维素纳米晶体的制备及其在复合材料中的应用[J]. 化学进展, 2021, 33(8): 1293-1310.
[11] 陈立忠, 龚巧彬, 陈哲. 超薄二维MOF纳米材料的制备和应用[J]. 化学进展, 2021, 33(8): 1280-1292.
[12] 向笑笑, 田晓雯, 刘会娥, 陈爽, 朱亚男, 薄玉琴. 石墨烯基气凝胶小球的可控制备[J]. 化学进展, 2021, 33(7): 1092-1099.
[13] 江松, 王家佩, 朱辉, 张琴, 丛野, 李轩科. 二维材料V2C MXene的制备与应用[J]. 化学进展, 2021, 33(5): 740-751.
[14] 杨英, 马书鹏, 罗媛, 林飞宇, 朱刘, 郭学益. 多维CsPbX3无机钙钛矿材料的制备及其在太阳能电池中的应用[J]. 化学进展, 2021, 33(5): 779-801.
[15] 陈怡峰, 王聪, 任科峰, 计剑. 生物医用高通量研究中的微液滴阵列[J]. 化学进展, 2021, 33(4): 543-554.
阅读次数
全文


摘要

载银缓释型抗菌敷料