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化学进展 2009, Vol. 21 Issue (0708): 1546-1552 前一篇   后一篇

• 综述与评论 •

可降解聚氨酯型组织工程多孔支架材料的制备*

姚响;庹新林**;王晓工   

  1. (清华大学化工系高分子研究所   |北京 |100084)
  • 收稿日期:2008-09-15 修回日期:2008-11-10 出版日期:2009-08-24 发布日期:2009-06-30
  • 通讯作者: 庹新林 E-mail:tuoxl@mail.tsinghua.edu.cn
  • 基金资助:

    863项目

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Preparing Biodegradable Polyurethane Porous Scaffold for Tissue Engineering Application

Yao Xiang |Tuo Xinlin** |Wang Xiaogong   

  1. (Institute of Polymer Science and Engineering| Department of Chemical Engineering| Tsinghua University| Beijing 100084, China)
  • Received:2008-09-15 Revised:2008-11-10 Online:2009-08-24 Published:2009-06-30
  • Contact: Tuo Xinlin E-mail:tuoxl@mail.tsinghua.edu.cn

本文在可降解型聚氨酯分子设计，聚氨酯型组织工程支架制备方法，可降解聚氨酯多孔支架的生物学性能及可降解聚氨酯多孔支架在组织工程中的应用等几个方面对可降解聚氨酯型组织工程支架的最新研究进展作了综述。重点讨论了静电纺丝、冷冻干燥、相分离等几种聚氨酯多孔支架制备方法以及聚氨酯型组织工程支架的生物降解性质、生长因子嵌入、生物力学性能、生物相容性等生物学性能。目前的研究表明通过聚氨酯分子设计与各种支架制备方法结合可制得满足各种生物学性能的支架材料且这类材料已被证实在血管、软骨、骨等各类组织工程中有重要的应用价值。但如何进一步提高聚氨酯支架材料的力学强度以使其能更好地与硬组织的力学性能相匹配以及如何降低或消除聚氨酯对人体的毒性仍是需要进一步研究的问题。

关键词： 可降解聚氨酯, 组织工程, 多孔支架

Recent development in some facets for the investigation of biodegradable polyurethane tissue engineering scaffold including biodegradable polyurethane molecular design, fabrication methods of polyurethane tissue engineering scaffold, the biological properties of the biodegradable polyurethane porous scaffold and the application of biodegradable polyurethane porous scaffold in tissue engineering are reviewed. We focus on several polyurethane scaffold preparation methods such as electrostatic spinning, freeze drying, phase separation and some biological properties such as biological degradation property, the imbed of growth factor agent, biological mechanical property and biocompatibility, etc. Recent progress indicates that it is possible to fabricate various kinds of scaffold material which may meet the demand of various kinds of biological properties through the combination of polyurethane molecular design and those scaffold fabrication methods and it has been confirmed that this kind of material has great potential in the application such as vascular, cartilage and bone tissue engineering. However, the mechanical strength of the polyurethane scaffold should be further boosted in order to match the mechanical property of the hard tissue and the toxicity of the polyurethane should be further decreased or eliminated in the future investigation.

Contents
1 The molecular design of biodegradable polyurethane
2 The fabrication methods of polyurethane tissue engineering scaffold
2.1 Electrospun
2.2 Freeze drying
2.3 Phase separation
3 Biological properties of biodegradable polyurethane scaffold
3.1 Biodegradabilty
3.2 Incorporation of growth factor
3.3 Biomechanics
3.4 Biocompatibity
4 Conclusion and prospects

Key words: biodegradable polyurethane, tissue engineering, porous scaffold

中图分类号: 

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