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化学进展 2009, Vol. 21 Issue (0708): 1494-1499 前一篇   后一篇

• 综述与评论 •

硒蛋白S的生物学功能*

曾金红;张功臣;黄开勋**   

  1. （华中科技大学化学系 |武汉 430074）
  • 收稿日期:2008-09-08 修回日期:2008-12-20 出版日期:2009-08-24 发布日期:2009-06-30
  • 通讯作者: 黄开勋 E-mail:hxxzrf@mail.hust.edu.cn
  • 基金资助:

    国家自然科学基金

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Biological Functions of Selenoprotein S

Zeng Jinhong |Zhang Gongchen ; |Huang Kaixun**   

  1. (Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China)
  • Received:2008-09-08 Revised:2008-12-20 Online:2009-08-24 Published:2009-06-30
  • Contact: Huang Kaixun E-mail:hxxzrf@mail.hust.edu.cn

硒蛋白S是一种新发现的内质网和细胞膜驻留硒蛋白。以往的研究结果揭示硒蛋白S可以保护细胞拮抗氧化损伤及内质网应激诱导的细胞凋亡；参与脂蛋白代谢、精子发育过程、炎症反应及将错误折叠蛋白从内质网腔逆向转移到细胞质中然后降解的过程(即内质网相关蛋白降解)。硒蛋白S基因多态性与糖尿病、冠状动脉心脏病或先兆子痫等疾病密切相关。本文结合本课题组的工作对硒蛋白S的最新研究进展，尤其是硒蛋白S功能的研究成果作了较为详细的介绍，并对未来的研究方向作了展望。

关键词： 硒蛋白S, 氧化损伤, 内质网应激, 炎症

Selenoprotein S (SelS) is a new endoplasmic reticulum (ER) and plasma membrane resident selenoprotein. Previous studies reveal that SelS protects cells from oxidative damage and endoplasmic reticulum stress-induced apoptosis. It participates in the retro-translocation of misfolded proteins from the ER lumen to cytosol for degradation (ER-associated protein degradation). SelS is involved in spermatogenesis, lipoprotein metabolism and the regulation of inflammatory response. Polymorphism of SelS is closely associated with chronic inflammatory diseases such as diabetes, coronary heart disease and preeclampsia. This paper reviews the recent research progress on SelS, especially its biological functions, with authors′s work about the role of SelS in inflammatory response. Finally, some issues to be addressed and potential orientations to be further studied are also put forward and prospected.

Contents
1 Characterization and tissue distribution of SelS
2 Biological functions of SelS
2.1 Antioxidative damage
2.2 Regulation of ER stress
2.3 ER–associated protein degradation
2.4 Role in spermatogenesis
2.5 Related to lipoprotein metabolism
2.6 Involving in inflammatory response
2.7 Associated with insulin resistance
2.8 Polymorphism of SelS gene and diseases
3 Prospects

Key words: selenoprotein S, oxidative damage, endoplasmic reticulum stress, inflammation

中图分类号: 

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摘要

硒蛋白S的生物学功能*