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化学进展 2009, Vol. 21 Issue (05): 990-996 前一篇   后一篇

• 综述与评论 •

铱-氮膦配体催化剂在非官能化烯烃不对称氢化中的研究*

陈传杰; 魏作君**; 李艳; 任其龙   

  1. （浙江大学材化学院制药工程研究所     杭州 310027）
  • 收稿日期:2008-06-05 修回日期:2008-06-27 出版日期:2009-05-24 发布日期:2009-05-05
  • 通讯作者: 魏作君 E-mail:weizuojun@zju.edu.cn
  • 基金资助:

    国家自然科学基金;省级资助

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Asymmetric Hydrogenation of Unfunctionalized Alkenes Catalyzed by Ir-N,P-Ligands Catalysts

Chen Chuanjie;  Wei Zuojun**;  Li Yan ; Ren Qilong   

  1. (Institute of Pharmaceutical Engineering, College of Materials Science and Chemical Engineering, Hangzhou 310027, China)
  • Received:2008-06-05 Revised:2008-06-27 Online:2009-05-24 Published:2009-05-05
  • Contact: Wei Zuojun E-mail:weizuojun@zju.edu.cn

非官能化烯烃的不对称氢化反应一直是烯烃加氢领域的难点。研究表明，铱-氮膦配体催化剂对此类反应具有很好的催化活性和选择性，因而受到国内外众多学者的关注。本文对近年来利用铱-氮膦配体催化剂对非官能化烯烃进行不对称氢化的研究进展进行了综述，介绍了不对称氢化的历程及背景，着重讨论了铱-氮膦配体催化剂的催化机理（IrⅢ-IrⅤ催化循环机理、IrⅠ-IrⅢ催化循环机理）、铱催化剂的组成以及催化性能的比较，并对铱催化剂在不对称氢化中的发展前景作了展望。

关键词： 铱催化剂, 氮膦配体, 非官能化烯烃, 不对称氢化

The asymmetric hydrogenation of unfunctionalized alkenes which the carbon-carbon double bonds are connected only to totally aliphatic groups is always a challenge in the field of alkene hydrogenation. It is reported that such reaction can be catalyzed by Ir-N, P-ligand catalysts with excellent catalytic activity and high enantioselectivity, which deserves much attention over the world. In the present review, the progress on asymmetric hydrogenation of unfunctionalized alkenes catalyzed by Ir-N,P-ligand catalysts are described, including the background of the hydrogenation history, the catalytic mechanisms (IrIII-IrV cycle mechanism and IrI-IrIII cycle mechanism), the composition of the catalysts (the precursors of Ir catalysts, the chiral ligands and the anions) and the comparison of their reactivity while catalyzing olefins with di-, tri- and tetra- substituted alkyl groups. The prospective of the asymmetric hydrogenation of unfunctionalized alkenes by Ir-N,P-ligand is also pvesented.

Contents
1 Catalytic mechanisms of Ir-N, P-ligand catalysts
2 Structure of Ir-N,P-ligand catalysts
2.1 The precursors of Ir catalysts
2.2 The chiral ligands of Ir catalysts
2.3 The anions of Ir catalysts
3 Comparison of hydrogenation activity of Ir-N,P-ligand catalysts
4 Conclusion and prospective

Key words: iridium catalysts, N,P-ligand, unfunctionalized alkenes, asymmetric hydrogenation

中图分类号: 

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