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化学进展 2009, Vol. 21 Issue (05): 896-902 前一篇   后一篇

• 金属药物专辑 •

钒化合物抗糖尿病作用的研究进展*

韦丹; 丁文军**; 周桔 ;彭端 ;李明   

  1. （中国科学院研究生院生命科学学院环境与健康研究室    北京   100049）
  • 收稿日期:2009-02-03 修回日期:2009-01-27 出版日期:2009-05-24 发布日期:2009-05-05
  • 通讯作者: 丁文军 E-mail:dingwj@gucas.ac.cn
  • 基金资助:

    国家自然科学基金

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Research Progress in Anti-Diabetic Effects of Vanadium Compounds

Wei Dan; Ding Wenjun**; Zhou Ju; Peng Duan; Li Ming   

  1. (Laboratory of Environment and Health, College of Life Sciences, Graduate University of Chinese Academy of Sciences, Beijing 100049, China)
  • Received:2009-02-03 Revised:2009-01-27 Online:2009-05-24 Published:2009-05-05
  • Contact: Ding Wenjun E-mail:dingwj@gucas.ac.cn

在糖尿病的治疗研究中，体内和体外的研究表明，钒化合物可以降低I型和II型糖尿病血糖，促进葡萄糖转运和糖原合成，具有“类胰岛素作用”。本文综述了近年来钒化合物在降低和改善糖尿病症状的生物效应及其通过胰岛素信号通路在降糖作用的分子机制的研究进展。

关键词： 钒化合物, 糖尿病, 抗糖尿病作用

It is well known that diabetes mellitus (DM) is a chronic disease caused by inherited and/or acquired deficiency in production of insulin by the pancreas, or by the ineffectiveness of the insulin produced. Numerous studies have shown that vanadium and its compounds improve glucose homeostasis and insulin resistance in Type I and Type II diabetes mellitus. Vanadium and its compounds appear to have a profound impact on insulin action through the insulin signaling cascade, but the underlying mechanism is not fully understood. This review summarizes recent work to identify the effects of pharmaceutical treatment of vanadium compounds on insulin signaling and glucose uptake, in an attempt to characterize the molecular mechanism accounting for biological actions and insulin-mimesis of vanadium compounds in DM.

Contents
1 Introduction
2 Chemical properties of vanadium and anti-diabetic actions of vanadium compounds
2.1 Chemical properties of vanadium
2.2 Anti-diabetic actions of vanadium compounds
3 Mechanism of anti-diabetic effects of vanadium compounds
3.1 Coordination chemistry of vanadium compounds
3.2 Vanadium compounds and PTP1B
3.3 Vanadium compounds and glucose transport
3.4 Vanadium compounds and metabolism of glycogen and lipid
3.5 Molecular mechanism of insulin-mimetic action of vanadium compounds
4 Issues and perspective

Key words: vanadium compounds, diabetes mellitus, anti-diabetic effect

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