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化学进展 2009, Vol. 21 Issue (05): 890-895 前一篇   后一篇

• 金属药物专辑 •

从钒化合物生物效应的多样性看其作用机制*

杨晓改**; 王琴; 刘竟成; 王夔   

  1. (北京大学药学院化学生物学系  北京100191)
  • 收稿日期:2009-02-02 修回日期:2009-01-27 出版日期:2009-05-24 发布日期:2009-05-05
  • 通讯作者: 杨晓改 E-mail:yxg@bjmu.edu.cn
  • 基金资助:

    国家自然科学基金

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Mechanisms Underlying Diversified Biological Effects of Vanadium Compounds

Yang Xiaogai**; Wang Qin;  Liu Jingcheng; Wang Kui   

  1. (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China,)
  • Received:2009-02-02 Revised:2009-01-27 Online:2009-05-24 Published:2009-05-05
  • Contact: Yang Xiaogai E-mail:yxg@bjmu.edu.cn

本文对近年来关于钒化合物不同生物效应机制的研究进展进行了总结，着重于其类胰岛素和抗癌效应的信号转导机制以及两者之间的相关性。同时，基于钒化合物对磷酸转移反应的干预以及对细胞氧化还原状态的调节，讨论了钒化合物多样化的生物效应是否具有一个共同作用机制的可能性，并提出了未来钒化合物研究方向和所面临的挑战。

关键词： 类胰岛素, 抗癌, 钒化合物

In this review, the authors present a brief overview of research progress on mechanisms underlying the diversified biological effects of vanadium compounds. This review focuses on the signaling pathways mediating the insulin-mimetic and anticancer effects of vanadium compounds, as well as the correlationship between them. Besides, based on their intervention on phosphate transfer reactions and roles in modulating cellular redox reactions, the possibility of a universal mechanism is discussed. Finally, both the tendency and the challenge in the vanadium research are indicated.

Contents
1 Introduction
2 Antidiabetic effects and underlying mechanisms of vanadium compounds
2.1 Diabetes and insulin signaling pathway
2.2 Activation of insulin signaling pathway and action mechanisms of vanadium compounds
3 Anticancer effects and underlying mechanisms of vanadium compounds
4 Whether or not a unifying mechanism underlying diversified biological effects of vanadium compounds exists
5 Perspective

Key words: insulin-mimetic, anticancer, vanadium compounds

中图分类号: 

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