[ 1 ] 　Klaassen C D. Heavy Metals and Heavy-Metal Antagonists. in :Goodman & Gilmanps The Pharmacological Basis of Therapeutics(Eds. Hardman J G, Gilman A G, Limbird L E) . New York :McGraw-Hill , 1996 , 1649 —1672
[ 2 ] 　Haller J S. Pharm. Hist . , 1975 , 17 : 87 —100
[ 3 ] 　Aronson SM. Arsenic and Old Myths. R IMed. , 1994 , 77 : 233 —234
[ 4 ] 　Kwong YL , Todd D. Blood , 1997 , 89 : 3487 —3488
[ 5 ] 　Cutler E G, Bradford E H. Am. J . Med. Sci . , 1878 , 75 : 74 —84
[ 6 ] 　Forkner C E , Scott T FM. J . Am. Med. Assoc. , 1931 , 97 : 3 —5
[ 7 ] 　Lykknes A , Kvittingen L. J . Chem. Educ. , 2003 , 80 : 497 —500
[ 8 ] 　Levanson A S. J . Chem. Educ. , 1977 , 54 : 98 —99
[ 9 ] 　Lloyd N C , Morgan H W, Nicholson B K, et al . Angew. Chem.Int . Ed. , 2005 , 44 : 941 —944
[10 ] 　Tarnowski G S , Schmid F A , Cappuccino J G, et al . Cancer Res. ,1966 , 26 : 181 —206
[11 ] 　Chan P C , Huff J . J . Environ. Sci . Health Part C , 1997 , 15 : 83 —122
[12 ] 　Keiser J , Ericsson ; , Burri C. Clin. Pharmacol . & Ther. , 2000 ,67 : 478 —488
[13 ] 　Niu C , Yan H , Chen GQ , et al . Blood , 1991 , 94 : 3315 —3324
[14 ] 　Shen Z X, Chen G Q , Ni J H , et al . Blood , 1997 , 89 : 3354 —3360
[15 ] 　Zhang T D , Chen G Q , Wang Z G, et al . Oncogene , 2001 , 20 :7146 —7153
[16 ] 　Hu J , Fang J , Dong Y, et al . Anticancer Drugs , 2005 , 16 : 119 —127
[17 ] 　Waxman S , Anderson K C. Oncologist , 2001 , 6 : 3 —10
[18 ] 　Dilda P J , Hogg P J . Cancer Treatment Rev. , 2007 , 33 : 542 —564
[19 ] 　Wang Z G, Rivi R , Delva L , et al . Blood , 1998 , 92 : 1497 —1504
[20 ] 　Rousselot P , Larghero J , Labaume S , et al . Eur. J . Haematol . ,2004 , 72 : 166 —171
[21 ] 　Koshiuka K, Elstner E , Williamson E , et al . Br. J . Cancer , 2000 ,82 : 452 —458
[22 ] 　Gibaud S , Zirar S B , Mutzenhardt P , et al , Int . J . Pharm. , 2005 ,306 : 107 —121
[23 ] 　Thomas D J , Styblo M, Lin S. Toxicol . Appl . Pharmacol . , 2001 ,176 : 127 —144
[24 ] 　Duzkale H , Jilani I , Orsolic N , et al . Cancer Chemother.Pharmacol . , 2003 , 51 : 427 —432
[25 ] 　Don A S , Kisker O , Dilda P , et al . Cancer Cell , 2003 , 3 : 497 —509
[26 ] 　McStay G P , Clarke S J , Halestrap A P. Biochem. J . , 2002 , 367 :541 —548
[27 ] 　Golemovic M, Orsolic N , Zingaro R , et al . ASH Annual Meeting Abstract , 2003
[28 ] 　Kornblau S M, Jackson C E , Worthing A , et al . ASCO Annual Meeting Proceedings. 2006
[29 ] 　Reglinski J . Environmental and Medicinal Chemistry of Arsenic ,Antimony and Bismuth , in : Chemistry of Arsenic , Antimony and Bismuth , ( Ed. Norman N C) , London : Blavkie Academic & Professional , 1998
[30 ] 　Sun H , Zhang L , Szeto K Y. Metal Ions Biol . Syst . , 2004 , 41 :333 —378
[31 ] 　Zhu J , Chen Z, Lallemand-Breitenbach V. Nat . Rev. Cancer ,2002 , 2 : 705 —714
[32 ] 　Schmidt H , Peter F M. Advances in the Therapeutics of Antimony ,Leipzig : Thieme Verlag , 1938
[33 ] 　Berman J D. Rev. Infect . Dis. , 1988 , 10 : 560 —586
[34 ] 　Vianna G. Arch. Bras. Méd. , 1912 , 2 : 426 —428
[35 ] 　Vianna G. Arch. Bras. Méd. , 1913 , 3 : 1171
[36 ] 　Christopherson J B. Lancet Ⅱ, 1918 , 325 —327
[37 ] 　McDonagh J E R. Lancet Ⅱ, 1918 , 371
[38 ] 　Christopherson J B. Brit . Med. J . , 1918 , 2 : 652 —653
[39 ] 　Luckey T D , Venugopal B. Metal Toxicity in Mammals (Vol . 2) ,New York : Plenum Press , 1997
[40 ] 　Aggarwal P , Handa R , Singh S , et al . Ind. J . Pediatr. , 1999 , 66 :63 —71
[41 ] 　Olliaro P L , Bryceson A D M. Parasitol . Today , 1993 , 9 : 323 —328
[42 ] 　Kirk R , Stai M H. Ann. Trop. Med. Parasitol . , 1947 , 41 : 14 —21
[43 ] 　Roberts W L , McMurray W J , Rainey P M. Antimicrob. Agents Chemother. , 1998 , 42 : 1076 —1082
[44 ] 　The leishmaniasis. Report of a WHO Expert Committee. WHO Tech.Rep. Ser. , 1984 , 701 : 1 —140
[45 ] 　Herwaldt B L , Berman J D. Am. J . Trop. Med. Hyg. , 1992 , 46 :296 —306
[46 ] 　Berman J D , Chulay J D , Hendricks L D , et al . Am. J . Trop.Med. Hyg. , 1982 , 31 : 459 —465
[47 ] 　Faraut-Gambarelli F , Piarroux R , Deniau M, et al . Antimicrob.Agents Chemother. , 1997 , 41 : 827 —830
[48 ] 　Grogl M, Thomason T N , Franke E D. Am. J . Trop. Med. Hyg. ,1992 , 47 : 117 —126
[49 ] 　Winship K A. Adv. Drug React . Ac. Pois. Rev. , 1987 , 6 :67 —90
[50 ] 　Duffin J , Campling B GJ . History Med. , 2002 , 57 : 61 —78
[51 ] 　Tiekink E R T. Crit . Rev. Onol . Hematol . , 2002 , 42 : 217 —224
[52 ] 　Ozturk I I , Hadjikakou S K, Hadjiliadis N , et al . Inorg. Chem. ,2007 , 46 : 8652 —8661
[53 ] 　Fairlamb A H , Blackburn P , Ulrich P , et al . Science , 1985 , 227 :1485 —1487
[54 ] 　Fairlamb A H. Progress in Polyamine Research : Novel Biochemical ,Pharmacological and Clinical Aspects , 1988 , 667 —674
[55 ] 　Fairlamb A H , Cerami A. Ann. Rev. Microbiol . , 1992 , 46 : 695 —729
[56 ] 　Yan S , Ding K, Zhang L , et al . Angew. Chem. Int . Ed. , 2000 ,39 : 4260 —4262
[57 ] 　Yan S , Wong I L K, ChowL M C , et al . Chem. Commun. , 2003 ,266 —267
[58 ] 　Yan S , Li F , Ding K. J . Biol . Inorg. Chem. , 2003 , 8 : 689 —697
[59 ] 　Shaked-Mishan P , Ulrich N , Ephros M, et al . J . Biol . Chem. ,2001 , 276 : 3971 —3976
[60 ] 　Zhou Y, Messier N , Ouellette M, et al . J . Biol . Chem. , 2004 ,279 : 37445 —37451
[61 ] 　Bisacchi D , Zhou Y, Rosen B P , et al . Acta Cryst . Section F ,2006 , F62 : 976 —979
[62 ] 　Zhou T, Radaev S , Rosen B P , et al . EMBOJ . , 2000 , 19 : 4838 —4845
[63 ] 　Chen C M, Misra T K, Silver S , et al . J . Biol . Chem. , 1986 ,261 : 15030 —15038
[64 ] 　Odier L. J . Med. Chir. Pharm. , 1786 , 68 : 49 —56
[65 ] 　Baxter G F. Chem. Brit . , 1992 , 445 —448
[66 ] 　Beales I L P. BMC Gastroenterology , 2001 , 1 : 7 —15
[67 ] 　Yang N , Sun H. Coord. Chem. Rev. , 2007 , 251 : 2354 —2366
[68 ] 　张志朋(Zhang Z P) , 钟国清(Zhang GQ) , 蒋琪英(Jiang Q Y) .化学进展(Progchem in Chemistry) , 2008 , 20 : 1315 —1323
[69 ] 　Ge R , Sun H. Acc. Chem. Res. , 2007 , 40 : 267 —274
[70 ] 　Briand G G, Burford N. Chem. Rev. , 1999 , 99 : 2601 —2657
[71 ] 　Suarez F L , Furne J , Stiehm J , et al . Dig. Dis. Sci . , 2000 , 45 :1444 —1446
[72 ] 　Iffland R. Bismuth , Handbook on Metals in Clinical and Analytical Chemistry , New York : Marcel Dekker , 1994 , 269 —281
[73 ] 　DuPont H L , Ericeeon C D. N. Engl . J . Med. , 1993 , 328 :1821 —1827
[74 ] 　Figueroa-Quintanilla D , Salazar-Lindo E , Sack R B. N. Engl . J .Med. , 1993 , 328 : 1653 —1658
[75 ] 　Bierer D W, Klapêt ke T. Biol . Met . , 1988 , 1 : 69 —76
[76 ] 　Nie Y, Li Y, Wu H. Helicobacter , 1999 , 4 : 128 —134
[77 ] 　Domenico P , Salo R J , Novick S G, et al . Antimicrob. Agents Chemother. , 1997 , 41 : 1697 —1703
[78 ] 　Kotani T, Nagai D , Asahi K, et al . Antimicrob. Agents Chemother. , 2005 , 49 : 2729 —2734
[79 ] 　Murafuji T, Miyoshi Y, Ishibashi M, et al . J . Inorg. Biochem. ,2004 , 98 : 547 —552
[80 ] 　Chen R , So M H , Yang J , et al . , Chem. Commun. , 2006 , 2265 —2267
[81 ] 　Kozak R W, Waldmann T A , Atcher R W, et al . Trends Biotechnol . , 1986 , 4 : 259 —264
[82 ] 　Burke J M, Jurcic J G, Scheinberg D A. Cancer Control , 2002 , 9 :106 —113
[83 ] 　Jurcic J G. Crit. Rev. Oncol. PHematol. , 2001 , 38 : 37 —45
[84 ] 　McDevitt M R , Nikula T N , Finn R D , et al . Tumor Targeting ,1996 , 2 : 182 —182
[85 ] 　McDevitt M R , Finn R D , Ma D , et al . , J . Nucl . Med. , 1999 ,40 : 1722 —1727
[86 ] 　Hassfjell S , Brechbiel MW. Chem. Rev. , 2001 , 101 : 2019 —2036
[87 ] 　Halime Z, Michaudet L , Lachkar M. Bioconjugate Chem. , 2004 ,15 : 1193 —1200
[88 ] 　Mulford D A , Scheinberg D A , Jurcic J G. J . Nucl . Med. , 2005 ,46 : 199s —204s
[89 ] 　Rizvi S M A , Li Y, Song E YJ , et al . Cancer Biol . Ther. , 2006 ,5 : 386 —393
[90 ] 　Kêpf-Maier P , Klapêtke T. Inorg. Chimica Acta , 1988 , 152 :49 —52
[91 ] 　Smith KA , Deacon GB , Jackson W R , et al . Metal-Based Drugs ,1998 , 5 : 295 —304
[92 ] 　Wang X Y, Zhang X M, Lin J , et al . J . Chem. Soc. Dalton Trans. , 2003 , 2379 —2380
[93 ] 　Kondo Y, Satoh M, Imura N , et al . Cancer Chemother.Pharmacol . , 1991 , 29 : 19 —23
[94 ] 　Kondo Y, Himeno S , Satoh M, et al . Cancer Chemother.Pharmacol . , 2004 , 53 : 33 —38
[95 ] 　Yang N , Tanner J A , Zheng B , et al . Angew. Chem. Int . Ed. ,2007 , 46 : 6464 —6468
[96 ] 　Yang N , Tanner J A , Wang Z, et al . Chem. Commun. , 2007 ,4413 —4415
[97 ] 　Sadler P J , Sun H , Li H. Chem. Eur. J . , 1996 , 2 : 701 —708
[98 ] 　Burford N , Eelman M D , Mahony D E , et al . Chem. Commun. ,2003 , 146 —147
[99 ]   Burford N , Eelman MD , Groom K. J . Inorg. Biochem. , 2005 , 99 :1992 —1997
[100 ] Sun H , Li H , Sadler P J . Chem. Rev. , 1999 , 99 : 2817 —2842
[101 ] Sun H , Szeto K Y. J . Inorg. Biochem. , 2003 , 94 : 114 —120
[102 ] Li H , Sadler PJ , Sun H. J . Biol . Chem. , 1996 , 271 : 9483 —9489
[103 ] Sun H , Li H , Mason A B , et al . Biochem. J . , 1999 , 337 :105 —111
[104 ] Zhang L , Szeto K Y, Wong W B , et al . Biochemistry , 2001 , 40 :13281 —13287
[105 ] Britigan B E , Lewis T S , McCormick ML , et al . Adv. Exp. Med.Biol . , 1998 , 443 : 135 —140
[106 ] Sun H , Li H , Harvey I , et al . J . Biol . Chem. , 1999 , 274 :29094 —29101
[107 ] Magnusson N E , Larsen A , Rungby J , et al . , Cell Tissue Res. ,2005 , 321 : 195 —210
[108 ] Ge R , Sun X, Gu Q , et al . J . Biol . Inorg. Chem. , 2007 , 12 :831 —842
[109 ] Ge R , Zhang Y, Sun X, et al . J . Am. Chem. Soc. , 2006 , 128 :11330 —11331
[110 ] Cun SJ , Li H , Ge R , et al . J . Biol . Chem. , 2008 , 283 : 15142 —15151
[111 ] Sun X, Tsang C N , Sun H. Metallomics , 2009 , 1 : 25 —31.
[112 ] Lambert J R , Midolo P. Aliment . Pharmacol . Ther. , 1997 , 11(Suppl . ) : 27 —31
[113 ] Turkez H , Geyikoglu F , Keles M S. Biol . Trace. Elem. Res. ,2005 , 105 : 151 —158
[114 ] Salaspuro M. Helicobacter Pylori Alcohol Dehydrogenase , in : Toward a Molecular Basis of Alcohol Use and Abuse , ( Eds. Jansson B ,Jêrnvall H , Rydberg U , Terenius L , Vallee B L) , Switzerland :Birkh? user Verlag , Basel , 1994 , 185 —195
[115 ] Jin L , Szeto K Y, Zhang L , et al . J . Inorg. Biochem. , 2004 , 98 :1331 —1337
[116 ] Mulrooney S B , Hausinger R P. FEMSMicrobiol . Rev. , 2003 , 27 :239 —261
[117 ] Zhang L , Mulrooney S B , Leung A F K, et al . BioMetals , 2006 ,19 : 503 —511