English
往期目录
新闻公告
More
化学进展 2009, Vol. 21 Issue (05): 803-818 前一篇   后一篇

• 金属药物专辑 •

从细胞无机化学的角度看镧系元素化合物作为诊疗药物的安全性问题*

王夔**; 杨晓改**   

  1. (北京大学医学部药学院化学生物学系 北京100191)
  • 收稿日期:2009-02-06 修回日期:2009-01-27 出版日期:2009-05-24 发布日期:2009-05-05
  • 通讯作者: 王夔; 杨晓改 E-mail:wangkui@bjmu.edu.cn; yxg@bjmu.edu.cn
  • 基金资助:

    国家自然科学基金

下载PDF ( 2922 ) 引用
导出

Safety Issues of Lanthanides-Based Compounds as Diagnostic and Therapeutic Agents as Viewed from Cellular Inorganic Chemistry

Wang Kui** ;  Yang Xiaogai**   

  1. (Department of Chemical Biology, School of Pharmaceutical Sciences,
    Peking University Health Science Center, Beijing 100191, China,)
  • Received:2009-02-06 Revised:2009-01-27 Online:2009-05-24 Published:2009-05-05
  • Contact: Wang Kui; Yang Xiaogai E-mail:wangkui@bjmu.edu.cn; yxg@bjmu.edu.cn

近几年来，在稀土农用安全性的争议尚未彻底解决之际，其作为诊疗药物使用的安全性问题又成为研究的焦点。本文从细胞无机化学的角度，提出了其中几个关键问题，并从下面几方面进行了分析讨论。第一，生物体系中的固相形成和沉积问题。因为在研究稀土的生物效应以及解释其有关临床病理表现时，均会涉及到难溶化合物的形成、转化以及分布和调控；第二，在正常和病理条件下，稀土化合物的吸收、排出与积累问题，尤其是稀土跨血-组织屏障的问题，这也是关于稀土是否产生毒性的争论焦点；第三，从相似/相异性规律出发, 探讨了稀土元素引起生物效应的共性和特性；第四，讨论了稀土化合物促进细胞增殖凋亡的信号转导机制以及所引发的问题。并在此基础上，提出了在细胞层次研究金属离子及配合物的生物效应时所面临的关键问题。

关键词： 稀土, 细胞无机化学, 相似/相异性规律, 增殖, 细胞信号转导, 安全性

The controversy about the safety issue concerning the agricultural application of lanthanides(Ln) has not yet been completely resolved. In recent years, the scientific basis of the safety in relation to their uses as diagnostic agents and potential drugs has become the research focus. This review proposed several related critical problems in view of the cellular inorganic chemistry and discussed them from the following aspects. First, the role of the solid-phase formation and deposition in biological systems, as in the study of the biological effects of Ln, as well as elucidation of their performance on the clinical pathology, the formation, transformation, distribution and modulation of insoluble compounds have always been involved. Second, issues on the absorption, excretion and accumulation of Ln, especially on whether Ln cross the blood-tissue barriers, it is one of the foci of debate over their toxicity. Third, in the light of the similarity/dissimilarity principle, the common and specific characteristics of biological effects induced by Ln elements have been discussed. Fourth, the signaling pathways involved in the Ln-promoted cell proliferation and apoptosis, as well as the arising problems have been discussed. Based on the above discussions, the key issues faced by the cellular and biological studies on the metal ions or metal-based compounds have been proposed.

Contents
1 Safety issues of lanthanides-based compounds as diagnostic and therapeutic agents
1.1 Gd-based compounds may cause nephrogenic systemic fibrosis(NSF)
1.2 Cerium levels has been related to endomyocardial fibrosis (EMF)
1.3 Debate on the safety of lanthanum carbonate（Fosrenol®）
1.4 About anticancer drug Gd-Motexafin
2 Formation and deposition of solid phases of lanthanide compounds in biological systems
2.1 Precipitation is an inevitable problem in studies on biological effects of lanthanides
2.2 Chemical species of metal compounds under biological conditions
2.3 Chemical essence of transmetallation
3 Absorption, transport and accumulation of lanthanide compounds
3.1 Absorption, transport and accumulation of lanthanide compounds under pathological conditions
3.2 Whether Ln can cross blood-tissue barriers under pathological conditions?
4 How to explain the differential biological effects among lanthanides?
4.1 Similarity/dissimilarity principle for lanthanides induced biological effects
4.2 Diversity among lanthanides
5 Mechanism underlying lanthanides-promoted proliferation and apoptosis, as well as the arising problems
5.1 Is lanthanides' action a hormetic effect?
5.2 Whether lanthanides-induced apoptosis effect can be used for cancer treatment?
5.3 Possible signal transduction pathways involved in lanthanides-induced cell proliferation and apoptosis
5.4 May lanthanides-promoted proliferation trigger carcinogenic or mutagenic effects?
6 Concluding remarks

Key words: lanthanides, cellular inorganic chemistry, similarity/dissimilarity principle, proliferation, cell signaling pathway, safety

中图分类号: 

()

[ 1 ] 　Wang K, Li R , Cheng Y, et al . Coord. Chem. Rev. , 1999 , 190/192 : 297 —308
[ 2 ] 　Adding L C , Bannenberg G L , Gustafsson L E. Cardiovasc Drug Rev. , 2001 , 19 : 41 —56
[ 3 ] 　Wang K, Cheng Y, Yang XD , et al . Cell Responses to Lanthanides and Potential Pharmacological Actions of Lanthanides. New York :Marcel Dekker , Inc. , 2003
[ 4 ] 　Fricker S P. Chem. Soc. Rev. , 2006 , 35 : 524 —533
[ 5 ] 　杨晓改(Yang X G) , 杨晓达(Yang X D) , 王夔(Wang K) . 化学进展(Progress in Chemistry) , 2007 , 19 : 201 —204
[ 6 ] 　Amato R J , Jac J , Hernandez-McClain J . Clin. Genitourin Cancer ,2008 , 6 : 73 —78
[ 7 ] 　William WN , Zinner R G, Karp D D , et al . J . Thorac. Oncol . ,2007 , 2 : 745 —750
[ 8 ] 　Thomas S R , Khuntia D. Int . J . Nanomedicine , 2007 , 2 : 79 —87
[ 9 ] 　倪嘉缵(Ni J Z) . 稀土生物无机化学(第二版) (Bioinorganic Chemistry of Rare Earths) . 北京: 科学出版社(Beijing : Science Press) , 2002
[10 ] 　Sze G, Berry I , Brant-Zawadzki M, et al . Acta Radiol . Suppl . ,1986 , 369 : 568 —571
[11 ] 　Cowper S E , Robin H S , Steinberg SM, et al . Lancet , 2000 , 356 :1000 —1001
[12 ] 　Cowper S E , Bucala R. Am. J . Dermatopathol . , 2003 , 25 : 358
[13 ] 　Grobner T. Nephrol . Dial . Transplant . , 2006 , 21 : 1104 —1108
[14 ] 　Thomsen H S , Marckmann P , Logager V B. Cancer Imaging , 2007 ,7 : 130 —137
[15 ] 　Michaely HJ , Thomsen H S , Reiser M F , et al . Radiologe , 2007 ,47 : 785 —793
[16 ] 　Thomsen H S , Morcos S K, Dawson P. Clin. Radiol . , 2006 , 61 :905 —906
[17 ] 　Davies J N P. East Afr. Med. J . , 1948 , 25 : 10 —16
[18 ] 　Yin R. Chin. Med. Sci . J . , 2000 , 15 : 55 —60
[19 ] 　Bukhman G, Ziegler J , Parry E. PLoS Negl . Trop. Dis. , 2008 , 2 :art . no. e97
[20 ] 　Eapen J T. Bull . Environ. Contam. Toxicol . , 1998 , 60 : 168 —170
[21 ] 　Andy J J . West Afr. J . Med. , 2001 , 20 : 199 —207
[22 ] 　Smith B. British Geology Survey Technical Report WCP98P26 , 1998 ,Natural Environment Research Council
[23 ] 　Preeta R , Nair R R. J . Mol . Cell Cardiol . , 1999 , 31 : 1573 —1580
[24 ] 　Nair R R , Preeta R , Smitha G, et al . Biol . Trace Elem. Res. ,2003 , 94 : 237 —246
[25 ] 　Aime S , Canavese C , Stratta P. Kidney Int . , 2007 , 72 : 1162 —1163
[26 ] 　Shelley W B , Hurley H J , Mayock R L , et al . J . Invest .Dermatol . , 1958 , 31 : 301 —303
[27 ] 　Brambilla S , Valaperta S , Graziani G, et al . Clin. Biochem. ,2008 , 41 : 1029 —1033
[28 ] 　De Broe M E. Semin. Dial . , 2008 , 21 : 142 —144
[29 ] 　朱为方( Zhu W F) , 徐素琴( Xu S Q) . 科学通报( Science Bulletin) , 1996 , 41 : 914 —916
[30 ] 　王瑜(Wang Y) , 赵晓宁(Zhao X N) . 中华劳动卫生职业病杂志( Chinese Journal of Industrial Hygiene and Occupational Diseases) , 1999 , 17 : 85 —87
[31 ] 　章子贵(Zhang Z G) , 申秀英(Shen X Y) , 许晓路(Xu X L) 等.浙江师范大学学报(自然科学版) (Journal of Zhejiang Normal University(Natural Sciences) ) , 2004 , 27 : 167 —170
[32 ] 　Briner W, Rycek R F , Moellenberndt A , et al . Neurotoxicol .Teratol . , 2000 , 22 : 573 —581
[33 ] 　Feng L , Xiao H , He X, et al . Neurotoxicol . Teratol . , 2006 , 28 :119 —124
[34 ] 　章子贵(Zhang Z G) , 陈燕珍(Chen Y Z) , 申秀英(Shen X Y)等. 环境与职业医学(Journal of Environmental and Occupational Medicine) , 2007 , 24 : 193 —195
[35 ] 　吴敏仪(Wu M Y) , 张萍(Zhang P) , 杨维东(Yang WD) 等. 卫生研究(Journal of Hygiene Research) , 2006 , 3 : 310 —312
[36 ] 　Damment S J , de Broe M E , D’Haese P C , et al . Toxicol . Lett . ,2007 , 168 : 186 —189
[37 ] 　Altmann P , Barnett M E , Finn WF. Kidney Int . , 2007 , 71 : 252 —259
[38 ] 　Magda D , Miller R A. Semin. Cancer Biol . , 2006 , 16 : 466 —476
[39 ] 　Evans J P , Xu F , Sirisawad M, et al . Mol . Pharmacol . , 2007 , 71 :193 —200
[40 ] 　Mani C , Upadhyay S , Lacy S , et al . J . Pharm. Sci . , 2005 , 94 :559 —570
[41 ] 　Bingham D , Dobrota M. J . Inorg. Biochem. , 1995 , 59 : 39 —52
[42 ] 　López-González H , Solache-Ríos M, Jiménez-Reyes M, et al .Journal of Solution Chemistry , 2005 , 34 : 427 —441
[43 ] 　Luo Y R , Byrne R H. Geochimica et Cosmochimica Acta , 2004 ,68 : 691 —699
[44 ] 　Cetiner Z S , Wood S A , Gammons C H. Chemical Geology , 2005 ,217 : 147 —169
[45 ] 　Boland L M, Brown T A , Dingledine R. Brain Res. , 1991 , 563 :142 —150
[46 ] 　Caldwell R A , Clemo H F , Baumgarten C M. Am. J . Physiol . ,1998 , 275 : C619 —C621
[47 ] 　Barnhart J L , Kuhnert N , Bakan D A , et al . Magn. Reson.Imaging , 1987 , 5 : 221 —231
[48 ] 　Spencer A , Wilson S , Harpur E. Hum. Exp. Toxicol . , 1998 , 17 :633 —637
[49 ] 　Spencer A J , Wilson S A , Batchelor J , et al . Toxicol . Pathol . ,1997 , 25 : 245 —255
[50 ] 　Mizgerd J P , Molina R M, Stearns R C , et al . J . Leukoc. Biol . ,1996 , 59 : 189 —195
[51 ] 　Geiser M, Rothen-Rutishauser B , Kapp N , et al . Environ. Health Perspect . , 2005 , 113 : 1555 —1560
[52 ] 　Hocine N , Berry J P , Jaafoura H , et al . Cell Mol . Biol . , 1995 ,41 : 271 —278
[53 ] 　Lazar G. J . Reticuloendothel . Soc. , 1973 , 13 : 231 —237
[54 ] 　Wasserman A J , Monticello T M, Feldman R S , et al . Toxicol .Pathol . , 1996 , 24 : 588 —594
[55 ] 　Yoneda S , Emi N , Fujita Y, et al . Fundam. Appl . Toxicol . ,1995 , 28 : 65 —70
[56 ] 　Witt GC , May PM, Webb J , et al . Biometals , 1996 , 9 : 351 —361
[57 ] 　Jarvis N V , Wagener J M, Jackson G E. Journal of the Chemical Society Dalton Transactions , 1995 , 1411 —1415
[58 ] 　Kiss T, Odani A. Bulletin of the Chemical Society of Japan , 2007 ,80 : 1691 —1702
[59 ] 　Jackson G, Wynchank M, Woudenberg M. Mag. Reson. Med. ,1990 , 16 : 57 —66
[60 ] 　Jackson G, Byrne M. J . Nucl . Med. , 1996 , 37 : 379 —386
[61 ] 　孟路(Meng L) , 陈杭亭( Chen H T) . 高等学校化学学报(Chemical Journal of Chinese Universities) , 1999 , 20 : 5 —8
[62 ] 　Wang Y, Lu X, Wang S Y, et al . Chin. Chem. Lett . , 2001 , 12 :161 —162
[63 ] 　Lu X, Wang Y, Zhang H. Chin. Chem. Lett . , 2001 , 12 : 809 —812
[64 ] 　Zhang H Y, Lu X, Niu CJ , et al . Chinese Chemical Letters , 2002 ,13 : 658 —659
[65 ] 　Bell R A , Ogden N , Kramer J R. Comp. Biochem. Physiol . C Toxicol . Pharmacol . , 2002 , 133 : 175 —188
[66 ] 　Yokel R A , Lasley SM, Dorman D C. J . Toxicol . Environ. Health.B Crit . Rev. , 2006 , 9 : 63 —85
[67 ] 　Bresson C , Lamouroux C , Sandre C , et al . Biochimie , 2006 , 88 :1619 —1629
[68 ] 　Sun X, Tsang C N , Sun H. Metallomics , 2009 , 1 : 25 —31
[69 ] 　Kazy S K, Das S K, Sar P. J . Ind. Microbiol . Biotechnol . , 2006 ,33 : 773 —783
[70 ] 　Merroun M L , Chekroun K B , Arias J M, et al . Chemosphere ,2003 , 52 : 113 —120
[71 ] 　Nilsson J R. European Journal of Protistology , 2003 , 39 : 468 —474
[72 ] 　Nilsson J R. Acta Protozool . , 2003 , 42 : 19 —30
[73 ] 　Bucala R. J . Am. Coll . Radiol . , 2008 , 5 : 36 —39
[74 ] 　Behra2Miellet J , Gressier B , Brunet C , et al . Methods Find. Exp.Clin. Pharmacol . , 1996 , 18 : 437 —442
[75 ] 　Sarka L , Burai L , Brucher E. Chemistry , 2000 , 6 : 719 —724
[76 ] 　Lacour B , Lucas A , Auchere D , et al . Kidney Int . , 2005 , 67 :1062 —1069
[77 ] 　Canavese C , Mereu C , Nordio M, et al . Curr. Med. Chem. , 2005 ,12 : 1631 —1636
[78 ] 　McLeod C , Cox A , Bramall N. Kidney Int . , 2005 , 68 : 2906.author reply 2906 —2907
[79 ] 　Rambeck W. Kidney Int . , 2005 , 68 : 2909. author reply 2909 —2910
[80 ] 　Slatopolsky E , Liapis H , Finch J . Kidney Int . , 2005 , 68 : 2809 —2813
[81 ] 　Damment S J . Kidney Int . , 2006 , 70 : 1372 —1373. author reply1373
[82 ] 　Dorovini2Zis K, Sato M, Goping G, et al . Acta Neuropathol . ,1983 , 60 : 49 —60
[83 ] 　周晓波( Zhou X B) , 魏幼璋(Wei Y Z) . 生命科学研究(Life Science Research) , 1999 , 3 : 30 —35
[84 ] 　Feng L , Xiao H , He X, et al . Toxicol . Lett . , 2006 , 165 : 112 —120
[85 ] 　Feng L , He X, Xiao H , et al . Biol . Trace Elem. Res. , 2007 ,117 : 89 —104
[86 ] 　胡珊珊(Hu S S) , 申秀英(Shen X Y) , 许晓路(Xu XL) 等. 中国公共卫生(Chinese Journal of Public Health) , 2008 , 34 —35
[87 ] 　陈祖义(Chen Z Y) , 刘玉(Liu Y) . 农村生态环境(Journal of Ecology and Rural Environment) , 2002 , 18 : 52 —55
[88 ] 　Cheng Y, Yao H , Lin H , et al . Chem. Biol . Interact . , 1999 , 121 :267 —289
[89 ] 　Cheng Y, Liu M, Li R , et al . Biochim. Biophys. Acta , 1999 ,1421 : 249 —260
[90 ] 　Cheng Y, Chen B , Lu J , et al . J . Inorg. Biochem. , 1998 , 69 :1 —7
[91 ] 　Adding L C , Bannenberg G L , Gustafsson L E. Pharmacol .Toxicol . , 1998 , 83 : 8 —15
[92 ] 　Pletnev I V , Zernov V V. Analytica Chimica Acta , 2002 , 455 :131 —142
[93 ] 　Kinraide T B , Yermiyahu U. J . Inorg. Biochem. , 2007 , 101 :1201 —1213
[94 ] 　Corson D C , Williams T C , Sykes B D. Biochemistry , 1983 , 22 :5882 —5889
[95 ] 　Nitz M, Sherawat M, Franz KJ , et al . Angew. Chem. Int . Ed.Engl . , 2004 , 43 : 3682 —3685
[96 ] 　Schubert D , Dargusch R , Raitano J , et al . Biochem. Biophys. Res.Commun. , 2006 , 342 : 86 —91
[97 ] 　Niu J , Azfer A , Rogers L M, et al . Cardiovasc. Res. , 2007 , 73 :549 —559
[98 ] 　Heckert E G, Seal S , Self W T. Environ. Sci . Technol . , 2008 ,42 : 5014 —5019
[99 ] 　安宜(An Y) , 李荣昌(Li R C) , 王夔(Wang K) . 中国稀土学报(J . of Rare Earths) , 2005 , 23 : 105
[100 ] 刘会雪(Liu H X) , 杨晓达(Yang XD) , 王夔(Wang K) . 中国稀土学报(J . of Rare Earths) , 2006 , 24 : 484 —488
[101 ] 张金超(Zhang J C) , 许善锦(Xu S J ) , 王夔(Wang K) 等. 科学通报(Chinese Science Bulletin) , 2003 , 48 : 1767 —1771
[102 ] Shinohara A , Chiba M, Inaba Y. Mater. Sci . Forum. , 1999 , 315/317 : 368 —372
[103 ] Shinohara A , Chiba M, Inaba Y. Journal of Alloys and Compounds ,2006 , 408 : 405 —408
[104 ] Ding S , Liang T, Zhang C , et al . J . Exp. Bot . , 2005 , 56 : 2765 —2775
[105 ] Praeger F C , Gilchrest B A. Proc. Soc. Exp. Biol . Med. , 1989 ,190 : 28 —34
[106 ] 程水娥(Cheng S E) , 陈兴安(Chen X A) . 卫生毒理学杂志(Journal of Toxicology) , 1995 , 9 : 51 —51
[107 ] 聂毓秀(Nie Y X) , 张树功(Zhang S G) . 中国稀土学报(J . of Rare Earths) , 1989 , 7 : 58 —64
[108 ] 聂毓秀(Nie Y X) , 张树功(Zhang S G) . 中国稀土学报(J . of Rare Earths) , 1990 , 8 : 350 —353
[109 ] 王玺(Wang X) , 安丽芝(An L Z) . 中国稀土学报(J . of Rare Earths) , 1998 , 16 : 252 —256
[110 ] Zhang J C , Xu S J , Wang K. Prog. Nat . Sci . , 2003 , 13 : 266
[111 ] Zhang D W, Zhang J C , Chen Y, et al . Progress in Natural Science ,2007 , 17 : 618 —623
[112 ] Shi Y, Gou B D , Shi YL , et al . Biometals , 2008 , doi : 10. 1007/s10534 —008-9168-1
[113 ] 刘会雪(Liu H X) , 杨晓达(Yang XD) , 王夔(Wang K) . 中国稀土学报(J . of Rare Earths) , 2004 , 22 : 434
[114 ] Calabrese EJ , Baldwin L A. Crit . Rev. Toxicol . , 2001 , 31 : 353 —424
[115 ] Gaddipati J P , Rajeshkumar N V , Grove J C , et al . Nonlinearity in Biology , Toxicology , and Medicine , 2003 , 1 : 199 —212
[116 ] Valko M, Rhodes C J , Moncol J , et al . Chem. Biol . Interact . ,2006 , 160 : 1 —40
[117 ] Lehnert B E , Iyer R. Hum. Exp. Toxicol . , 2002 , 21 : 65 —69
[118 ] Damelin L H , Alexander J J . Hum. Exp. Toxicol . , 2001 , 20 :347 —358
[119 ] Liu H , Yuan L , Yang X, et al . Chem. Biol . Interact . , 2003 , 146 :27 —37
[120 ] Shimada H , Nagano M, Funakoshi T, et al . J . Toxicol . Environ.Health , 1996 , 48 : 81 —92
[121 ] 栗建林(Su J L) , 张丽帼(Zhang L G) , 刘建中(Liu J Z) 等. 中国稀土学报(J . of Rare Earths) , 1998 , 16 : 184 —187
[122 ] 庞新民(Pang XM) , 苏英(Su Y) . 卫生毒理学杂志(Journal of Toxicology) , 1995 , 9 : 120 —120
[123 ] 刘玉荣(Liu YR) , 陈东(Chen D) , 姜文华(Jiang W H) 等. 吉林大学学报: 医学版(Journal of Jilin University(Medicine Edition) ) ,2006 , 32 : 1029 —1033
[124 ] Ji YJ , Xiao B , Wang Z H , et al . Biomed. Environ. Sci . , 2000 ,13 : 287 —292
[125 ] 吴春利(Wu C L) , 刘洁生(Liu J S) , 杨维东(Yang W D) 等. 中国稀土学报(J . of Rare Earths) , 2003 , 21 : 323 —327
[126 ] 李晓滨(Li X B) , 陈兴安(Chen X A) . 中国稀土学报(J. of Rare Earths) , 2000 , 18 : 156 —159
[127 ] 曾先捷(Zeng XJ ) , 邝晓聪(Kuang X C) , 温冠媚(Wen GM) 等.广西医科大学学报(Journal of Guangxi Medical University) ,2001 , 18 : 776 —777
[128 ] 李剑(Li J ) , 李洁(Li J ) , 戴革(Dai G) 等. 中华血液学杂志(Chinese Journal of Hematology) , 2006 , 27 : 60 —62
[129 ] Zhang Y, Fu L J , Li J X, et al . Biometals , 2009 , doi: 10. 1007/s10534 —009-9208-5
[130 ] Fu L J , Li J X, Yang X G, et al . J . Biol . Inorg. Chem. , 2009 ,14 : 219 —227
[131 ] Yu S , Hu J , Yang X, et al . Biochemistry , 2006 , 45 : 11217 —11225
[132 ] Wang X, Yuan L , Huang J , et al . J . Cell . Biochem. , 2008 , 105 :1307 —1315
[133 ] 程驿( Cheng Y) , 李友(Li Y) . 中国稀土学报(J . of Rare Earths) , 1999 , 17 : 54 —59
[134 ] 劳凤云(Lao F Y) , 李荣昌(Li R C) . 中国稀土学报(J . of Rare Earths) , 2002 , 20 : 342 —347
[135 ] Du XL , Zhang TL , Yuan L , et al . Eur. J . Biochem. , 2002 , 269 :6082 —6090
[136 ] Hu J , Jia X, Li Q , et al . Biochemistry , 2004 , 43 : 2688 —2698
[137 ] Yang Q , Hu J , Yang X, et al . J . Inorg. Biochem. , 2008 , 102 :278 —284
[138 ] 徐(Xu K) . 北京大学博士论文(Doctoral Dissertation of Peking University) , 2008
[139 ] Hu J , Yang X, Wang K. J . Biol . Inorg. Chem. , 2005 , 10 : 704 —711
[140 ] Jha A M, Singh A C. Mutat . Res. , 1995 , 341 : 193 —197
[141 ] 卢晓翠(Lu X C) , 王登高(Wang D G) . 癌变. 畸变. 突变(Carcinogenesis , Teratogenesis &Mutagenesis) , 1995 , 7 : 93 —95
[142 ] 王信隆(Wang X L) , 芦燕青(Lu Y Q) . 癌变. 畸变. 突变(Carcinogenesis , Teratogenesis &Mutagenesis) , 1996 , 8 : 38 —40
[143 ] 纪云晶(Ji YJ ) . 中国稀土学报(稀土卫生毒理学专辑) ( J . of Rare Earths) , 1985 , 1 —10
[144 ] Joseph P , Muchnok T K, Klishis ML , et al . Toxicol . Sci . , 2001 ,61 : 295 —303
[1] 陆峰, 赵婷, 孙晓军, 范曲立, 黄维. 近红外二区发光稀土纳米材料的设计及生物成像应用[J]. 化学进展, 2022, 34(6): 1348-1358.
[2] 张柏林, 张生杨, 张深根. 稀土元素在脱硝催化剂中的应用[J]. 化学进展, 2022, 34(2): 301-318.
[3] 牟泽怀, 王银军, 谢鸿雁. 稀土金属配合物催化芳香型乙烯基极性单体立构选择性聚合[J]. 化学进展, 2020, 32(12): 1885-1894.
[4] 程倩, 于佳酩, 霍薪竹, 沈雨萌, 刘守新. 稀土氟化物上转换荧光增强及应用[J]. 化学进展, 2019, 31(12): 1681-1695.
[5] 姜玲, 阙亚萍, 丁勇, 胡林华, 张昌能, 戴松元. 上/下转换材料在染料敏化太阳电池中的应用进展[J]. 化学进展, 2016, 28(5): 637-646.
[6] 李龙飞, 摆音娜, 雷鸣, 刘力. 橡胶硫化促进剂的研究进展[J]. 化学进展, 2015, 27(10): 1500-1508.
[7] 钟大根, 刘宗华, 左琴华, 薛巍. 高分子纳米材料与血浆蛋白的相互作用[J]. 化学进展, 2014, 26(04): 638-646.
[8] 赵传奇, 曲晓刚*. 稀土手性配合物在核酸识别及调控方面的研究[J]. 化学进展, 2013, 25(04): 539-544.
[9] 刘涛, 孙丽宁, 刘政, 仇衍楠, 施利毅. 稀土上转换发光纳米材料的应用[J]. 化学进展, 2012, 24(0203): 304-317.
[10] 肖成建, 陈晓军, 康春梅, 汪小琳. 锂陶瓷氚增殖剂的中子辐照性能与产氚行为[J]. 化学进展, 2011, 23(9): 1906-1914.
[11] 秦玉升, 王献红, 王佛松. 二氧化碳基共聚物[J]. 化学进展, 2011, 23(4): 613-622.
[12] 夏兰, 李素丽, 艾新平, 杨汉西. 锂离子电池的安全性技术[J]. 化学进展, 2011, 23(0203): 328-335.
[13] 吴凯, 张耀, 曾毓群, 杨军. 锂离子电池安全性能研究[J]. 化学进展, 2011, 23(0203): 401-409.
[14] 刘政, 孙丽宁, 施利毅, 张登松. 近红外稀土荧光在功能材料领域的研究进展[J]. 化学进展, 2011, 23(01): 153-164.
[15] 王延梅 王丽. 杯芳烃稀土配合物的光性能及应用*[J]. 化学进展, 2010, 22(0203): 427-432.