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化学进展 2009, Vol. 21 Issue (01): 134-142 前一篇   后一篇

• 综述与评论 •

基于金纳米棒的生物检测、细胞成像和癌症的光热治疗*

马占芳**;田乐;邸静;丁腾   

  1. (首都师范大学化学系 北京 100037)
  • 收稿日期:2008-04-03 修回日期:2008-04-22 出版日期:2009-01-24 发布日期:2009-01-25
  • 通讯作者: 马占芳 E-mail:mazhanfang@yahoo.com

Bio-Detection, Cellular Imaging and Cancer Photothermal Therapy Based on Gold Nanorods

Ma Zhanfang**;Tian Le;Di Jing;Ding Teng   

  1. (Department of Chemistry, Capital Normal University, Beijing 100037, China)
  • Received:2008-04-03 Revised:2008-04-22 Online:2009-01-24 Published:2009-01-25
  • Contact: Ma Zhanfang E-mail:mazhanfang@yahoo.com

由于金纳米棒颗粒独特的可调的表面等离子共振特性,使得金纳米棒颗粒在纳米复合材料和功能化纳米器件的构建、纳米生物技术、生物医学等领域具有广泛而重要的应用前景。本文综述了金纳米棒颗粒的生物检测、细胞成像和癌症的光热治疗方面的最新研究进展,并介绍了金纳米棒颗粒的光学性质和金纳米棒颗粒和几种主要的表面修饰方法,对金纳米棒颗粒在生物应用过程中存在的主要问题进行了讨论。

Due to unique and tunable surface plsmon resonance properties, gold nanorods have widely potential and important applications, i.e., fabrications of nanoconposites, nanodevices, nanobiotechnology, and biomedicine. Gold nanorods, therefore, have been attracted much attention. The latest advances on the applications of gold nanorods involving biological detection, cellular imaging, and cancer photothermal therapy are reviewed in this paper. Meanwhile the optical properties and several main approaches of surface modification of gold nanorods are also introduced. In addition the main issues existing in the biological applications are discussed.

Contents
1 Optical properties of gold nanorods
2 Surface modifications of gold nanorods
2.1 Silica-coated gold nanorods
2.2 Modification of gold nanorods using biomolecules
3. Applications of gold nanorods in biodetection, bioimaging, and cancer photothermal therapy
3.1 Applications of gold nanorods in bio-molecular detection
3.2 Applications of gold nanorods in cell imaging and cancer photothermal therapy
4 Conclusion and outlook

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