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化学进展 2008, Vol. 20 Issue (10): 1628-1634 前一篇   

• 综述与评论 •

生物医用材料表面仿细胞膜结构改性*

宫铭 杨珊 张世平 宫永宽**   

  1. (西北大学合成与天然功能分子化学教育部重点实验室 西北大学化学系 西安 710069)

  • 收稿日期:2007-11-16 修回日期:2008-01-30 出版日期:2008-10-24 发布日期:2008-10-25
  • 通讯作者: 宫永宽
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Surface Modification of Biomedical Materials with Cell Membrane Mimetic Structures

Gong Ming; Yang Shan; Zhang Shiping; Gong Yongkuan**   

  1. (Key Laboratory of Chemistry of Synthetic and Natural Functional Molecules of Ministry of Education, Department of Chemistry, Northwest University, Xi’an 710069, China)

  • Received:2007-11-16 Revised:2008-01-30 Online:2008-10-24 Published:2008-10-25
  • Contact: Gong Yongkuan
细胞膜因其固有的生物相容性，可以作为体内植入材料及器件表面生物相容化改性的范例。大量研究结果表明，用细胞外层膜的亲水官能团－磷酰胆碱基团修饰材料表面，可显著提高材料的生物相容性，具有广阔的应用前景。本文综述了用含磷酰胆碱基团小分子及聚合物进行仿细胞膜结构改性的各种方法及其代表性工作；讨论了不同方法得到的仿细胞膜结构表面的性能；总结了几种有影响的生物相容性机理；对仿细胞膜结构表面改性研究及应用的前景做了展望。
关键词： 生物医用材料, 生物相容性, 磷酰胆碱, 细胞膜, 表面改性
The cell membrane establishes an important paradigm for the surface modification of implantable devices because of its intrinsic biocompatibility. Numerous researches have suggested that the biocompatibility of materials can be improved remarkably after modified with phosphorylcholine group, which is the major head group of the phospholipid of the cells outer membrane. This kind of membrane mimetic surfaces shows practical and scientifically importance in variety of biomaterials. The methods of fabricating membrane mimetic surfaces are categorized and the resulting surface properties are discussed along with introducing the representative researches. Several important mechanisms of biocompatibiliy are also summarized. Finally, the prospects of the research on membrane mimetic surfaces are suggested.
Key words: biomaterials, biocompatibility, phosphorylcholine, cell membrane, surface modification

中图分类号: 

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